ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 27/288 136/7206 2.45735555066e-12 ko04080 Neuroactive ligand-receptor interaction 49/288 423/7206 6.17856759942e-12 ko04724 Glutamatergic synapse 27/288 152/7206 3.79511201348e-11 ko04720 Long-term potentiation 19/288 99/7206 8.90787323447e-09 ko05031 Amphetamine addiction 18/288 91/7206 1.34587766485e-08 ko04024 cAMP signaling pathway 32/288 279/7206 5.2569831993e-08 ko04728 Dopaminergic synapse 25/288 185/7206 6.92471454922e-08 ko04911 Insulin secretion 19/288 117/7206 1.49728655652e-07 ko04514 Cell adhesion molecules (CAMs) 20/288 130/7206 1.75641262392e-07 ko05033 Nicotine addiction 13/288 56/7206 2.04121669448e-07 ko04721 Synaptic vesicle cycle 14/288 80/7206 2.70584605859e-06 ko04970 Salivary secretion 15/288 95/7206 4.53050521615e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 13/288 74/7206 5.91434579122e-06 ko04727 GABAergic synapse 16/288 110/7206 6.53283965432e-06 ko04971 Gastric acid secretion 15/288 98/7206 6.72963761082e-06 ko04745 Phototransduction - fly 9/288 38/7206 1.34658508869e-05 ko04261 Adrenergic signaling in cardiomyocytes 22/288 205/7206 2.06989667326e-05 ko04921 Oxytocin signaling pathway 22/288 209/7206 2.80274141466e-05 ko04626 Plant-pathogen interaction 6/288 18/7206 4.7824974405e-05 ko04925 Aldosterone synthesis and secretion 14/288 105/7206 6.69124042459e-05 ko04020 Calcium signaling pathway 25/288 265/7206 6.79250831792e-05 ko05030 Cocaine addiction 11/288 73/7206 0.00013385236903 ko04022 cGMP-PKG signaling pathway 21/288 216/7206 0.000135924738344 ko04725 Cholinergic synapse 17/288 160/7206 0.000206273485034 ko04730 Long-term depression 11/288 78/7206 0.000244990179994 ko05010 Alzheimer's disease 19/288 202/7206 0.000665883850247 ko04360 Axon guidance 20/288 233/7206 0.00105301152418 ko04114 Oocyte meiosis 14/288 139/7206 0.00126202499219 ko05032 Morphine addiction 12/288 110/7206 0.00139649550783 ko04540 Gap junction 13/288 128/7206 0.00173130838879 ko04924 Renin secretion 10/288 86/7206 0.00213913772507 ko04723 Retrograde endocannabinoid signaling 16/288 175/7206 0.00236381752454 ko04726 Serotonergic synapse 13/288 137/7206 0.00317312758555 ko04740 Olfactory transduction 9/288 80/7206 0.00440985048579 ko04964 Proximal tubule bicarbonate reclamation 5/288 29/7206 0.00531102825117 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/288 59/7206 0.00870365749065 ko04912 GnRH signaling pathway 11/288 122/7206 0.00936169084275 ko05034 Alcoholism 18/288 238/7206 0.010053152842 ko04270 Vascular smooth muscle contraction 13/288 154/7206 0.0102370434879 ko04014 Ras signaling pathway 20/288 279/7206 0.0113469286612 ko04972 Pancreatic secretion 10/288 111/7206 0.0130139614538 ko04916 Melanogenesis 12/288 142/7206 0.0140261178462 ko04260 Cardiac muscle contraction 9/288 98/7206 0.016073086691 ko04922 Glucagon signaling pathway 11/288 128/7206 0.0183125235156 ko04966 Collecting duct acid secretion 4/288 26/7206 0.0186520254751 ko02024 Quorum sensing 3/288 15/7206 0.0201135798237 ko05203 Viral carcinogenesis 4/288 277/7206 0.0266454482738 ko03040 Spliceosome 1/288 145/7206 0.0312271270932 ko04066 HIF-1 signaling pathway 10/288 123/7206 0.0313419513949 ko04742 Taste transduction 6/288 61/7206 0.0341066751712 ko05214 Glioma 7/288 79/7206 0.0378328155681 ko05110 Vibrio cholerae infection 6/288 63/7206 0.0390945508602 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/288 1/7206 0.0399666944213 ko04015 Rap1 signaling pathway 18/288 278/7206 0.0407017374117 ko04931 Insulin resistance 1/288 137/7206 0.0450800394234 ko00680 Methane metabolism 4/288 34/7206 0.0451819252478 ko04120 Ubiquitin mediated proteolysis 1/288 138/7206 0.0452766954648 ko05161 Hepatitis B 2/288 173/7206 0.0488567860869