ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1060	423/7206	1.31314673715e-45
ko04724	Glutamatergic synapse	85/1060	152/7206	6.56788998574e-33
ko05033	Nicotine addiction	47/1060	56/7206	6.16381430761e-31
ko04721	Synaptic vesicle cycle	52/1060	80/7206	7.87644886891e-25
ko05032	Morphine addiction	62/1060	110/7206	1.71671372508e-24
ko04713	Circadian entrainment	68/1060	136/7206	9.77718573261e-23
ko04727	GABAergic synapse	60/1060	110/7206	9.97256314215e-23
ko04728	Dopaminergic synapse	81/1060	185/7206	4.16847907933e-22
ko04725	Cholinergic synapse	70/1060	160/7206	3.25821776952e-19
ko04723	Retrograde endocannabinoid signaling	72/1060	175/7206	6.48499634241e-18
ko04024	cAMP signaling pathway	96/1060	279/7206	3.6680425631e-17
ko04921	Oxytocin signaling pathway	77/1060	209/7206	7.84485583543e-16
ko04742	Taste transduction	35/1060	61/7206	1.12722202575e-14
ko04020	Calcium signaling pathway	87/1060	265/7206	3.22849298957e-14
ko04744	Phototransduction	25/1060	36/7206	1.41584813399e-13
ko04726	Serotonergic synapse	55/1060	137/7206	2.00105036128e-13
ko05031	Amphetamine addiction	42/1060	91/7206	5.63103254223e-13
ko04720	Long-term potentiation	44/1060	99/7206	8.11671898027e-13
ko04911	Insulin secretion	48/1060	117/7206	2.74884508206e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1060	205/7206	4.04782215675e-11
ko03040	Spliceosome	1/1060	145/7206	3.52182378355e-09
ko04060	Cytokine-cytokine receptor interaction	5/1060	191/7206	3.44258706965e-08
ko04970	Salivary secretion	35/1060	95/7206	6.89683026259e-08
ko05203	Viral carcinogenesis	14/1060	277/7206	3.65243923445e-07
ko04740	Olfactory transduction	30/1060	80/7206	3.81007389724e-07
ko05030	Cocaine addiction	28/1060	73/7206	5.41778619775e-07
ko05168	Herpes simplex infection	6/1060	182/7206	6.4319587734e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1060	74/7206	7.51194246613e-07
ko04925	Aldosterone synthesis and secretion	35/1060	105/7206	1.17620439344e-06
ko04971	Gastric acid secretion	33/1060	98/7206	1.91211748338e-06
ko04022	cGMP-PKG signaling pathway	58/1060	216/7206	2.18049558408e-06
ko04360	Axon guidance	61/1060	233/7206	3.1396662934e-06
ko04966	Collecting duct acid secretion	14/1060	26/7206	3.48308809631e-06
ko04745	Phototransduction - fly	17/1060	38/7206	8.36907533231e-06
ko04514	Cell adhesion molecules (CAMs)	38/1060	130/7206	1.57994605988e-05
ko04260	Cardiac muscle contraction	31/1060	98/7206	1.81103090448e-05
ko03013	RNA transport	7/1060	166/7206	1.89903951507e-05
ko05164	Influenza A	7/1060	167/7206	1.94427540077e-05
ko04010	MAPK signaling pathway	75/1060	321/7206	2.42746595641e-05
ko04730	Long-term depression	26/1060	78/7206	3.04892988315e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1060	79/7206	3.75540407372e-05
ko04120	Ubiquitin mediated proteolysis	5/1060	138/7206	4.4420955475e-05
ko04626	Plant-pathogen interaction	10/1060	18/7206	6.44455322667e-05
ko04540	Gap junction	36/1060	128/7206	7.21699287431e-05
ko04924	Renin secretion	27/1060	86/7206	7.9068687822e-05
ko05110	Vibrio cholerae infection	21/1060	63/7206	0.000198559886327
ko05169	Epstein-Barr virus infection	13/1060	206/7206	0.000203456328087
ko04110	Cell cycle	7/1060	145/7206	0.000207967519694
ko04621	NOD-like receptor signaling pathway	8/1060	157/7206	0.000220771564262
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1060	59/7206	0.000252330763874
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1060	14/7206	0.000280393874417
ko04371	Apelin signaling pathway	44/1060	177/7206	0.000336546670008
ko04972	Pancreatic secretion	31/1060	111/7206	0.000343103726347
ko04014	Ras signaling pathway	63/1060	279/7206	0.000372037786022
ko04064	NF-kappa B signaling pathway	3/1060	96/7206	0.00038384463935
ko05322	Systemic lupus erythematosus	8/1060	151/7206	0.000421007894114
ko04610	Complement and coagulation cascades	2/1060	79/7206	0.00062635748011
ko03008	Ribosome biogenesis in eukaryotes	2/1060	79/7206	0.00062635748011
ko04915	Estrogen signaling pathway	34/1060	131/7206	0.000666170649309
ko04750	Inflammatory mediator regulation of TRP channels	32/1060	122/7206	0.000718569266496
ko04612	Antigen processing and presentation	2/1060	77/7206	0.000941933215795
ko05162	Measles	6/1060	120/7206	0.00105642140119
ko05140	Leishmaniasis	2/1060	75/7206	0.00143698368159
ko05414	Dilated cardiomyopathy	29/1060	112/7206	0.00174593676151
ko04141	Protein processing in endoplasmic reticulum	13/1060	184/7206	0.00206426786002
ko04214	Apoptosis - fly	2/1060	72/7206	0.00208253941525
ko05205	Proteoglycans in cancer	23/1060	271/7206	0.00215582762786
ko05161	Hepatitis B	12/1060	173/7206	0.00220222195261
ko00480	Glutathione metabolism	1/1060	55/7206	0.00329877104755
ko04146	Peroxisome	4/1060	89/7206	0.00374919806719
ko04070	Phosphatidylinositol signaling system	28/1060	112/7206	0.00424935069987
ko01524	Platinum drug resistance	3/1060	76/7206	0.00494590324871
ko05034	Alcoholism	51/1060	238/7206	0.0049992191619
ko04072	Phospholipase D signaling pathway	43/1060	197/7206	0.0058316565465
ko04976	Bile secretion	21/1060	80/7206	0.00630287459303
ko04964	Proximal tubule bicarbonate reclamation	10/1060	29/7206	0.00634891991647
ko05166	HTLV-I infection	27/1060	292/7206	0.00672857136636
ko00310	Lysine degradation	3/1060	73/7206	0.00703346808107
ko04350	TGF-beta signaling pathway	6/1060	103/7206	0.00734254504678
ko03018	RNA degradation	4/1060	84/7206	0.00755435994881
ko04922	Glucagon signaling pathway	30/1060	128/7206	0.00776705370349
ko04630	Jak-STAT signaling pathway	9/1060	132/7206	0.00861635341596
ko04668	TNF signaling pathway	8/1060	120/7206	0.00904449577396
ko00240	Pyrimidine metabolism	7/1060	110/7206	0.00958311269766
ko05144	Malaria	1/1060	45/7206	0.0106299037339
ko00071	Fatty acid degradation	1/1060	45/7206	0.0106299037339
ko03420	Nucleotide excision repair	1/1060	46/7206	0.0107269408816
ko05010	Alzheimer's disease	43/1060	202/7206	0.011334013764
ko04916	Melanogenesis	32/1060	142/7206	0.0114953555357
ko05321	Inflammatory bowel disease (IBD)	2/1060	56/7206	0.0129074749283
ko04912	GnRH signaling pathway	28/1060	122/7206	0.0137467933044
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1060	100/7206	0.0145555958315
ko04114	Oocyte meiosis	31/1060	139/7206	0.0150499949738
ko05145	Toxoplasmosis	9/1060	126/7206	0.015103216299
ko00983	Drug metabolism - other enzymes	1/1060	42/7206	0.0158265341227
ko03022	Basal transcription factors	1/1060	44/7206	0.0163741433695
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1060	92/7206	0.017102937844
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1060	182/7206	0.0196224613264
ko04115	p53 signaling pathway	4/1060	74/7206	0.0199530379305
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1060	40/7206	0.0235167548001
ko00140	Steroid hormone biosynthesis	1/1060	41/7206	0.0241004452659
ko04210	Apoptosis	16/1060	180/7206	0.0247781814589
ko05131	Shigellosis	5/1060	82/7206	0.026739974643
ko00380	Tryptophan metabolism	2/1060	50/7206	0.0268019973668
ko00590	Arachidonic acid metabolism	2/1060	52/7206	0.0279004146226
ko00330	Arginine and proline metabolism	3/1060	61/7206	0.0279709373025
ko04330	Notch signaling pathway	3/1060	62/7206	0.0285399125402
ko04622	RIG-I-like receptor signaling pathway	3/1060	62/7206	0.0285399125402
ko05222	Small cell lung cancer	6/1060	89/7206	0.0337044587734
ko00982	Drug metabolism - cytochrome P450	1/1060	37/7206	0.0347675226158
ko00630	Glyoxylate and dicarboxylate metabolism	1/1060	38/7206	0.0354513265092
ko03410	Base excision repair	1/1060	38/7206	0.0354513265092
ko00260	Glycine, serine and threonine metabolism	2/1060	48/7206	0.0387515481826
ko04722	Neurotrophin signaling pathway	33/1060	160/7206	0.0413149951869
ko04071	Sphingolipid signaling pathway	33/1060	162/7206	0.0435310253743
ko04657	IL-17 signaling pathway	6/1060	87/7206	0.0457963552155