ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	173/946	423/7206	1.3747636061e-49
ko05033	Nicotine addiction	45/946	56/7206	2.89772822142e-30
ko04724	Glutamatergic synapse	75/946	152/7206	9.33665098918e-28
ko04721	Synaptic vesicle cycle	47/946	80/7206	5.45312166953e-22
ko04728	Dopaminergic synapse	76/946	185/7206	7.52919599178e-22
ko05032	Morphine addiction	56/946	110/7206	8.12184154554e-22
ko04727	GABAergic synapse	54/946	110/7206	3.98306718663e-20
ko04713	Circadian entrainment	59/946	136/7206	1.4629696909e-18
ko04725	Cholinergic synapse	63/946	160/7206	3.52295889652e-17
ko04723	Retrograde endocannabinoid signaling	66/946	175/7206	8.21494731708e-17
ko04024	cAMP signaling pathway	86/946	279/7206	2.84482417602e-15
ko04726	Serotonergic synapse	51/946	137/7206	5.35610716418e-13
ko04742	Taste transduction	31/946	61/7206	1.33517691106e-12
ko04921	Oxytocin signaling pathway	66/946	209/7206	1.70343204762e-12
ko04744	Phototransduction	23/946	36/7206	1.73428082011e-12
ko04020	Calcium signaling pathway	77/946	265/7206	2.92175355501e-12
ko04911	Insulin secretion	43/946	117/7206	6.03340302384e-11
ko05031	Amphetamine addiction	36/946	91/7206	2.02849532128e-10
ko04261	Adrenergic signaling in cardiomyocytes	60/946	205/7206	6.40319550895e-10
ko04720	Long-term potentiation	35/946	99/7206	1.21262786973e-08
ko05203	Viral carcinogenesis	9/946	277/7206	1.72390085732e-08
ko03040	Spliceosome	1/946	145/7206	6.07730620052e-08
ko05030	Cocaine addiction	27/946	73/7206	1.97392453092e-07
ko04060	Cytokine-cytokine receptor interaction	5/946	191/7206	6.01758400157e-07
ko04970	Salivary secretion	31/946	95/7206	6.47034528086e-07
ko04966	Collecting duct acid secretion	14/946	26/7206	8.577350438e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	26/946	74/7206	1.0554969577e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/946	79/7206	1.22742480996e-06
ko05168	Herpes simplex infection	5/946	182/7206	1.8633030972e-06
ko05164	Influenza A	4/946	167/7206	2.07901626529e-06
ko04010	MAPK signaling pathway	72/946	321/7206	2.63197419141e-06
ko04740	Olfactory transduction	26/946	80/7206	5.6013873181e-06
ko05322	Systemic lupus erythematosus	4/946	151/7206	1.34416702096e-05
ko04924	Renin secretion	26/946	86/7206	2.91483908894e-05
ko04360	Axon guidance	53/946	233/7206	4.29708497586e-05
ko04745	Phototransduction - fly	15/946	38/7206	4.31549669641e-05
ko04730	Long-term depression	24/946	78/7206	5.16448945051e-05
ko04260	Cardiac muscle contraction	28/946	98/7206	5.23375483604e-05
ko04971	Gastric acid secretion	28/946	98/7206	5.23375483604e-05
ko04120	Ubiquitin mediated proteolysis	4/946	138/7206	5.81930949055e-05
ko04022	cGMP-PKG signaling pathway	49/946	216/7206	8.58559428507e-05
ko05110	Vibrio cholerae infection	20/946	63/7206	9.68293437669e-05
ko04621	NOD-like receptor signaling pathway	6/946	157/7206	0.000110336528012
ko05169	Epstein-Barr virus infection	10/946	206/7206	0.000136147299075
ko03013	RNA transport	7/946	166/7206	0.000167265538511
ko04514	Cell adhesion molecules (CAMs)	33/946	130/7206	0.00018218391842
ko04925	Aldosterone synthesis and secretion	28/946	105/7206	0.000191868208135
ko04141	Protein processing in endoplasmic reticulum	9/946	184/7206	0.000343097875315
ko04612	Antigen processing and presentation	1/946	77/7206	0.000485797739395
ko04972	Pancreatic secretion	28/946	111/7206	0.000529579103534
ko04070	Phosphatidylinositol signaling system	28/946	112/7206	0.000580629758284
ko05205	Proteoglycans in cancer	18/946	271/7206	0.000656192142054
ko05161	Hepatitis B	9/946	173/7206	0.000855121351751
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/946	14/7206	0.000973794226524
ko05166	HTLV-I infection	21/946	292/7206	0.0013807661669
ko04014	Ras signaling pathway	55/946	279/7206	0.00149941651975
ko05162	Measles	5/946	120/7206	0.00154443126669
ko05414	Dilated cardiomyopathy	27/946	112/7206	0.0016015019645
ko04110	Cell cycle	7/946	145/7206	0.00166853724424
ko03008	Ribosome biogenesis in eukaryotes	2/946	79/7206	0.00216351597044
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/946	182/7206	0.00254142548857
ko05410	Hypertrophic cardiomyopathy (HCM)	24/946	100/7206	0.00256894766781
ko05140	Leishmaniasis	2/946	75/7206	0.00312796582536
ko04072	Phospholipase D signaling pathway	40/946	197/7206	0.00379906564542
ko00240	Pyrimidine metabolism	5/946	110/7206	0.00416534468631
ko04214	Apoptosis - fly	2/946	72/7206	0.00454077056093
ko04064	NF-kappa B signaling pathway	4/946	96/7206	0.00563989296651
ko04630	Jak-STAT signaling pathway	7/946	132/7206	0.00575627147042
ko00480	Glutathione metabolism	1/946	55/7206	0.00778814101331
ko04350	TGF-beta signaling pathway	5/946	103/7206	0.007958731893
ko04964	Proximal tubule bicarbonate reclamation	9/946	29/7206	0.00961088804065
ko04146	Peroxisome	4/946	89/7206	0.0109345813594
ko00590	Arachidonic acid metabolism	1/946	52/7206	0.0115723323602
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/946	92/7206	0.0116722916355
ko04140	Autophagy - animal	11/946	164/7206	0.0133633779139
ko04330	Notch signaling pathway	2/946	62/7206	0.0136958016188
ko04640	Hematopoietic cell lineage	2/946	64/7206	0.0139963682416
ko05219	Bladder cancer	1/946	48/7206	0.0167864658651
ko01200	Carbon metabolism	8/946	128/7206	0.0169863896986
ko05016	Huntington's disease	17/946	215/7206	0.0183274919768
ko00330	Arginine and proline metabolism	2/946	61/7206	0.0201948957699
ko04750	Inflammatory mediator regulation of TRP channels	25/946	122/7206	0.0207756671576
ko03018	RNA degradation	4/946	84/7206	0.0213623972892
ko00310	Lysine degradation	3/946	73/7206	0.021576754696
ko05145	Toxoplasmosis	8/946	126/7206	0.0226734052743
ko04626	Plant-pathogen interaction	6/946	18/7206	0.02307720098
ko04540	Gap junction	26/946	128/7206	0.0235844179136
ko03022	Basal transcription factors	1/946	44/7206	0.024689027797
ko05144	Malaria	1/946	45/7206	0.0248183340296
ko00071	Fatty acid degradation	1/946	45/7206	0.0248183340296
ko00620	Pyruvate metabolism	1/946	46/7206	0.0254329335683
ko03420	Nucleotide excision repair	1/946	46/7206	0.0254329335683
ko04915	Estrogen signaling pathway	26/946	131/7206	0.0262201871799
ko05323	Rheumatoid arthritis	19/946	89/7206	0.026578299282
ko05321	Inflammatory bowel disease (IBD)	2/946	56/7206	0.028141135897
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/946	59/7206	0.0301458941125
ko05215	Prostate cancer	7/946	111/7206	0.032455107898
ko04210	Apoptosis	14/946	180/7206	0.0329116263035
ko00140	Steroid hormone biosynthesis	1/946	41/7206	0.0363376277569
ko00983	Drug metabolism - other enzymes	1/946	42/7206	0.0366306455529
ko05202	Transcriptional misregulation in cancer	15/946	188/7206	0.0367801137329
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/946	15/7206	0.0373618847364
ko04657	IL-17 signaling pathway	5/946	87/7206	0.0374645831864
ko04668	TNF signaling pathway	8/946	120/7206	0.0393927025579
ko01524	Platinum drug resistance	4/946	76/7206	0.0395895921337
ko05206	MicroRNAs in cancer	14/946	177/7206	0.0415545047291
ko04071	Sphingolipid signaling pathway	30/946	162/7206	0.0451912718029