ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1102	423/7206	3.06351229614e-49
ko04724	Glutamatergic synapse	86/1102	152/7206	1.69597097944e-32
ko05033	Nicotine addiction	47/1102	56/7206	3.75179086422e-30
ko05032	Morphine addiction	65/1102	110/7206	2.91612344388e-26
ko04713	Circadian entrainment	72/1102	136/7206	6.24966272618e-25
ko04727	GABAergic synapse	60/1102	110/7206	7.83135461163e-22
ko04728	Dopaminergic synapse	81/1102	185/7206	5.41264706814e-21
ko04721	Synaptic vesicle cycle	47/1102	80/7206	3.73141457255e-19
ko04725	Cholinergic synapse	70/1102	160/7206	2.94634649398e-18
ko04723	Retrograde endocannabinoid signaling	74/1102	175/7206	3.28735139355e-18
ko04024	cAMP signaling pathway	98/1102	279/7206	5.44357769241e-17
ko04020	Calcium signaling pathway	92/1102	265/7206	1.84100276772e-15
ko04742	Taste transduction	36/1102	61/7206	4.74641992916e-15
ko04921	Oxytocin signaling pathway	76/1102	209/7206	2.47174251942e-14
ko04911	Insulin secretion	48/1102	117/7206	1.16695558877e-11
ko04726	Serotonergic synapse	53/1102	137/7206	1.48384734601e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1102	205/7206	3.5463326044e-11
ko04744	Phototransduction	23/1102	36/7206	4.41853086739e-11
ko05031	Amphetamine addiction	40/1102	91/7206	4.82318303651e-11
ko04720	Long-term potentiation	42/1102	99/7206	6.36664799376e-11
ko04360	Axon guidance	74/1102	233/7206	1.21184753419e-10
ko04970	Salivary secretion	39/1102	95/7206	9.92745550111e-10
ko03040	Spliceosome	1/1102	145/7206	1.35494270999e-09
ko05203	Viral carcinogenesis	12/1102	277/7206	6.55339311057e-09
ko05164	Influenza A	5/1102	167/7206	3.12732138746e-07
ko04022	cGMP-PKG signaling pathway	61/1102	216/7206	7.03384648007e-07
ko04060	Cytokine-cytokine receptor interaction	8/1102	191/7206	1.19001349121e-06
ko05030	Cocaine addiction	28/1102	73/7206	1.21604117545e-06
ko04925	Aldosterone synthesis and secretion	36/1102	105/7206	1.43185486606e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1102	74/7206	1.67528038767e-06
ko03013	RNA transport	6/1102	166/7206	1.77604295255e-06
ko05322	Systemic lupus erythematosus	5/1102	151/7206	3.0569114693e-06
ko05168	Herpes simplex infection	8/1102	182/7206	5.05426624458e-06
ko04971	Gastric acid secretion	33/1102	98/7206	5.68039093438e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1102	79/7206	9.27770560074e-06
ko04740	Olfactory transduction	28/1102	80/7206	1.13426143193e-05
ko04010	MAPK signaling pathway	78/1102	321/7206	1.5815012055e-05
ko04070	Phosphatidylinositol signaling system	35/1102	112/7206	1.60431300116e-05
ko04514	Cell adhesion molecules (CAMs)	39/1102	130/7206	1.92752599429e-05
ko04621	NOD-like receptor signaling pathway	7/1102	157/7206	2.54898981656e-05
ko05169	Epstein-Barr virus infection	12/1102	206/7206	3.11542758391e-05
ko04141	Protein processing in endoplasmic reticulum	10/1102	184/7206	4.23446027756e-05
ko04924	Renin secretion	28/1102	86/7206	5.44854330993e-05
ko04745	Phototransduction - fly	16/1102	38/7206	6.34178508623e-05
ko04972	Pancreatic secretion	33/1102	111/7206	9.02146908462e-05
ko05205	Proteoglycans in cancer	20/1102	271/7206	9.58267527153e-05
ko04260	Cardiac muscle contraction	30/1102	98/7206	0.000102521848163
ko05161	Hepatitis B	10/1102	173/7206	0.000154373717604
ko04966	Collecting duct acid secretion	12/1102	26/7206	0.000184716516671
ko04120	Ubiquitin mediated proteolysis	7/1102	138/7206	0.000282191453677
ko05414	Dilated cardiomyopathy	32/1102	112/7206	0.000284907338911
ko03008	Ribosome biogenesis in eukaryotes	2/1102	79/7206	0.000410101893692
ko05140	Leishmaniasis	2/1102	75/7206	0.000601225750912
ko04730	Long-term depression	24/1102	78/7206	0.000659192488965
ko04064	NF-kappa B signaling pathway	4/1102	96/7206	0.000884620977644
ko04110	Cell cycle	9/1102	145/7206	0.00102202501751
ko04014	Ras signaling pathway	62/1102	279/7206	0.00164217840616
ko05162	Measles	7/1102	120/7206	0.00198135374784
ko04612	Antigen processing and presentation	3/1102	77/7206	0.00230113113624
ko05110	Vibrio cholerae infection	19/1102	63/7206	0.00238506444254
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1102	14/7206	0.00244984712673
ko04072	Phospholipase D signaling pathway	46/1102	197/7206	0.00246673750784
ko04964	Proximal tubule bicarbonate reclamation	11/1102	29/7206	0.00246784148106
ko04976	Bile secretion	23/1102	80/7206	0.00247665510712
ko04146	Peroxisome	4/1102	89/7206	0.00261212032433
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1102	100/7206	0.00286205354213
ko04371	Apelin signaling pathway	42/1102	177/7206	0.00287151883078
ko04626	Plant-pathogen interaction	8/1102	18/7206	0.00304258618065
ko04750	Inflammatory mediator regulation of TRP channels	31/1102	122/7206	0.00324747909671
ko04540	Gap junction	32/1102	128/7206	0.00400378553122
ko04640	Hematopoietic cell lineage	2/1102	64/7206	0.00434413874347
ko05166	HTLV-I infection	28/1102	292/7206	0.00464699320671
ko04214	Apoptosis - fly	3/1102	72/7206	0.00473297555553
ko04140	Autophagy - animal	13/1102	164/7206	0.0059009372927
ko00330	Arginine and proline metabolism	2/1102	61/7206	0.00624348889015
ko04668	TNF signaling pathway	8/1102	120/7206	0.00669758867725
ko03420	Nucleotide excision repair	1/1102	46/7206	0.0069544000732
ko00240	Pyrimidine metabolism	7/1102	110/7206	0.00701271467134
ko00260	Glycine, serine and threonine metabolism	1/1102	48/7206	0.00731425159085
ko05219	Bladder cancer	1/1102	48/7206	0.00731425159085
ko05321	Inflammatory bowel disease (IBD)	2/1102	56/7206	0.00870128383609
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1102	59/7206	0.00944052635084
ko04915	Estrogen signaling pathway	31/1102	131/7206	0.00991211008752
ko04630	Jak-STAT signaling pathway	10/1102	132/7206	0.0101111210228
ko03022	Basal transcription factors	1/1102	44/7206	0.010419591074
ko00562	Inositol phosphate metabolism	23/1102	89/7206	0.0107171411133
ko05144	Malaria	1/1102	45/7206	0.0107436524562
ko00071	Fatty acid degradation	1/1102	45/7206	0.0107436524562
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1102	182/7206	0.011970727893
ko00280	Valine, leucine and isoleucine degradation	2/1102	54/7206	0.0126307336482
ko00480	Glutathione metabolism	2/1102	55/7206	0.0128970088603
ko03018	RNA degradation	5/1102	84/7206	0.013893347729
ko00310	Lysine degradation	4/1102	73/7206	0.0140403742473
ko04210	Apoptosis	16/1102	180/7206	0.0153431244471
ko00140	Steroid hormone biosynthesis	1/1102	41/7206	0.0154767463989
ko00983	Drug metabolism - other enzymes	1/1102	42/7206	0.0158103315722
ko05215	Prostate cancer	8/1102	111/7206	0.015932825427
ko04620	Toll-like receptor signaling pathway	7/1102	100/7206	0.0169785076504
ko05145	Toxoplasmosis	10/1102	126/7206	0.0174522662045
ko00590	Arachidonic acid metabolism	2/1102	52/7206	0.0185189679833
ko05131	Shigellosis	5/1102	82/7206	0.0193328206907
ko04622	RIG-I-like receptor signaling pathway	3/1102	62/7206	0.0196657671773
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1102	40/7206	0.0242409660542
ko04657	IL-17 signaling pathway	6/1102	87/7206	0.0244461370782
ko05133	Pertussis	6/1102	87/7206	0.0244461370782
ko00380	Tryptophan metabolism	2/1102	50/7206	0.0273642994728
ko05206	MicroRNAs in cancer	17/1102	177/7206	0.033928862883
ko00500	Starch and sucrose metabolism	1/1102	35/7206	0.0341758447739
ko04217	Necroptosis	17/1102	178/7206	0.034191592867
ko00982	Drug metabolism - cytochrome P450	1/1102	37/7206	0.0354388197016
ko01524	Platinum drug resistance	5/1102	76/7206	0.0356795284716
ko04930	Type II diabetes mellitus	14/1102	54/7206	0.0363725468191
ko04923	Regulation of lipolysis in adipocytes	19/1102	77/7206	0.0364964841198
ko04350	TGF-beta signaling pathway	8/1102	103/7206	0.0371728087435
ko00620	Pyruvate metabolism	2/1102	46/7206	0.0380064874017
ko00270	Cysteine and methionine metabolism	2/1102	47/7206	0.0389368932935
ko04270	Vascular smooth muscle contraction	33/1102	154/7206	0.0408024696316
ko05010	Alzheimer's disease	41/1102	202/7206	0.0476466306745
ko04115	p53 signaling pathway	5/1102	74/7206	0.0491332660306