ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 33/262 191/7206 3.16464875926e-14 ko05340 Primary immunodeficiency 14/262 30/7206 4.32353010174e-13 ko05164 Influenza A 28/262 167/7206 6.87111679627e-12 ko05145 Toxoplasmosis 23/262 126/7206 9.75636877076e-11 ko04612 Antigen processing and presentation 18/262 77/7206 1.64387082072e-10 ko05330 Allograft rejection 11/262 24/7206 1.95649397534e-10 ko05140 Leishmaniasis 17/262 75/7206 9.03609892306e-10 ko04650 Natural killer cell mediated cytotoxicity 19/262 97/7206 1.28165809145e-09 ko05320 Autoimmune thyroid disease 11/262 29/7206 2.30566537255e-09 ko05152 Tuberculosis 26/262 187/7206 2.78489674972e-09 ko05332 Graft-versus-host disease 9/262 18/7206 3.5364221329e-09 ko04659 Th17 cell differentiation 19/262 106/7206 6.11098856165e-09 ko05321 Inflammatory bowel disease (IBD) 14/262 56/7206 7.37737429212e-09 ko05168 Herpes simplex infection 25/262 182/7206 7.37878182082e-09 ko04621 NOD-like receptor signaling pathway 22/262 157/7206 4.26604866937e-08 ko04658 Th1 and Th2 cell differentiation 17/262 96/7206 4.77084997267e-08 ko05162 Measles 19/262 120/7206 5.0414280983e-08 ko04380 Osteoclast differentiation 19/262 134/7206 3.05943839467e-07 ko05150 Staphylococcus aureus infection 10/262 36/7206 3.74831569885e-07 ko04672 Intestinal immune network for IgA production 10/262 37/7206 4.97375698724e-07 ko05310 Asthma 7/262 17/7206 1.10356961459e-06 ko04940 Type I diabetes mellitus 9/262 32/7206 1.3027571647e-06 ko04145 Phagosome 20/262 162/7206 1.43491285868e-06 ko04217 Necroptosis 21/262 178/7206 1.64865016361e-06 ko04062 Chemokine signaling pathway 22/262 201/7206 3.28925092691e-06 ko04630 Jak-STAT signaling pathway 17/262 132/7206 5.06267380904e-06 ko04660 T cell receptor signaling pathway 16/262 124/7206 9.42064875439e-06 ko05133 Pertussis 13/262 87/7206 1.32901896639e-05 ko04640 Hematopoietic cell lineage 11/262 64/7206 1.59689228347e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/262 191/7206 1.81137393761e-05 ko04620 Toll-like receptor signaling pathway 13/262 100/7206 6.05492743682e-05 ko04622 RIG-I-like receptor signaling pathway 10/262 62/7206 6.87651411658e-05 ko03050 Proteasome 9/262 54/7206 0.000122460001961 ko05416 Viral myocarditis 9/262 55/7206 0.000141838668587 ko04514 Cell adhesion molecules (CAMs) 13/262 130/7206 0.000843263259694 ko05323 Rheumatoid arthritis 10/262 89/7206 0.00137338644106 ko04610 Complement and coagulation cascades 9/262 79/7206 0.00214758665124 ko05034 Alcoholism 1/262 238/7206 0.0023331137634 ko04064 NF-kappa B signaling pathway 10/262 96/7206 0.00243897030979 ko05132 Salmonella infection 10/262 98/7206 0.00284210902922 ko04360 Axon guidance 1/262 233/7206 0.00355078409223 ko05160 Hepatitis C 13/262 153/7206 0.0036754606025 ko04662 B cell receptor signaling pathway 9/262 88/7206 0.00449129225293 ko05144 Malaria 6/262 45/7206 0.00539676341589 ko05161 Hepatitis B 14/262 173/7206 0.0055961226911 ko04664 Fc epsilon RI signaling pathway 8/262 77/7206 0.00659042240727 ko05142 Chagas disease (American trypanosomiasis) 11/262 130/7206 0.00753172626656 ko05131 Shigellosis 8/262 82/7206 0.0095597334837 ko00590 Arachidonic acid metabolism 6/262 52/7206 0.0109247382927 ko04666 Fc gamma R-mediated phagocytosis 10/262 122/7206 0.0131027160595 ko00980 Metabolism of xenobiotics by cytochrome P450 5/262 40/7206 0.0142164994929 ko04310 Wnt signaling pathway 1/262 181/7206 0.0150807283323 ko04390 Hippo signaling pathway 1/262 188/7206 0.0155513371472 ko04623 Cytosolic DNA-sensing pathway 5/262 41/7206 0.0157240168041 ko04144 Endocytosis 21/262 342/7206 0.0169398131714 ko04611 Platelet activation 12/262 163/7206 0.017654043594 ko05016 Huntington's disease 2/262 215/7206 0.0250867173919 ko05204 Chemical carcinogenesis 5/262 48/7206 0.0292973715672 ko05010 Alzheimer's disease 2/262 202/7206 0.0350913851312 ko00982 Drug metabolism - cytochrome P450 4/262 37/7206 0.0440607743948 ko04080 Neuroactive ligand-receptor interaction 8/262 423/7206 0.0446450377384 ko05012 Parkinson's disease 1/262 155/7206 0.0464499709085 ko00480 Glutathione metabolism 5/262 55/7206 0.0486116601628