ko pathway ratio_in_study ratio_in_pop p_value ko04020 Calcium signaling pathway 71/842 265/7206 6.41558255302e-12 ko04080 Neuroactive ligand-receptor interaction 98/842 423/7206 7.34440230277e-12 ko04724 Glutamatergic synapse 45/842 152/7206 1.43754002355e-09 ko04713 Circadian entrainment 41/842 136/7206 4.33481616868e-09 ko04720 Long-term potentiation 29/842 99/7206 1.57462661284e-06 ko03010 Ribosome 1/842 129/7206 2.73502590875e-06 ko04911 Insulin secretion 32/842 117/7206 2.85044604268e-06 ko04921 Oxytocin signaling pathway 48/842 209/7206 2.92449290183e-06 ko04022 cGMP-PKG signaling pathway 49/842 216/7206 4.13432506455e-06 ko03040 Spliceosome 2/842 145/7206 5.11966437773e-06 ko04970 Salivary secretion 27/842 95/7206 6.7576559575e-06 ko04070 Phosphatidylinositol signaling system 30/842 112/7206 8.69618079914e-06 ko04710 Circadian rhythm 16/842 43/7206 1.30280117884e-05 ko04725 Cholinergic synapse 38/842 160/7206 1.50398131828e-05 ko04971 Gastric acid secretion 27/842 98/7206 1.7439479428e-05 ko04925 Aldosterone synthesis and secretion 28/842 105/7206 1.92023793912e-05 ko03013 RNA transport 4/842 166/7206 2.22413144045e-05 ko04110 Cell cycle 3/842 145/7206 3.52768719227e-05 ko04024 cAMP signaling pathway 56/842 279/7206 3.64222537324e-05 ko04726 Serotonergic synapse 33/842 137/7206 3.81620585645e-05 ko05033 Nicotine addiction 18/842 56/7206 3.85763872126e-05 ko05031 Amphetamine addiction 25/842 91/7206 3.93363603229e-05 ko04727 GABAergic synapse 28/842 110/7206 5.98897227209e-05 ko05322 Systemic lupus erythematosus 4/842 151/7206 9.32595839375e-05 ko05032 Morphine addiction 27/842 110/7206 0.000132573149178 ko05203 Viral carcinogenesis 14/842 277/7206 0.000176854423204 ko04730 Long-term depression 21/842 78/7206 0.000223494727907 ko04745 Phototransduction - fly 13/842 38/7206 0.000227359119598 ko04072 Phospholipase D signaling pathway 40/842 197/7206 0.000419142681603 ko04976 Bile secretion 20/842 80/7206 0.000718846703955 ko04261 Adrenergic signaling in cardiomyocytes 40/842 205/7206 0.000872864123402 ko04728 Dopaminergic synapse 37/842 185/7206 0.00101939504391 ko04964 Proximal tubule bicarbonate reclamation 10/842 29/7206 0.00112000100472 ko04922 Glucagon signaling pathway 28/842 128/7206 0.00116030186019 ko04270 Vascular smooth muscle contraction 32/842 154/7206 0.00130919309401 ko05224 Breast cancer 8/842 174/7206 0.0017322995082 ko04960 Aldosterone-regulated sodium reabsorption 12/842 41/7206 0.00188370555019 ko04924 Renin secretion 20/842 86/7206 0.00203373671622 ko04711 Circadian rhythm - fly 6/842 13/7206 0.00207472829323 ko04750 Inflammatory mediator regulation of TRP channels 26/842 122/7206 0.00241191895485 ko04972 Pancreatic secretion 24/842 111/7206 0.00250066837308 ko02010 ABC transporters 11/842 39/7206 0.0039647988688 ko04540 Gap junction 26/842 128/7206 0.0048899706656 ko00120 Primary bile acid biosynthesis 7/842 20/7206 0.00569970941697 ko04723 Retrograde endocannabinoid signaling 32/842 175/7206 0.00855715831695 ko04514 Cell adhesion molecules (CAMs) 25/842 130/7206 0.0121853274936 ko04626 Plant-pathogen interaction 6/842 18/7206 0.0134470748595 ko00564 Glycerophospholipid metabolism 20/842 99/7206 0.016618088398 ko00280 Valine, leucine and isoleucine degradation 1/842 54/7206 0.0176646982394 ko00520 Amino sugar and nucleotide sugar metabolism 1/842 55/7206 0.0180338913914 ko04550 Signaling pathways regulating pluripotency of stem cells 10/842 165/7206 0.0195590039389 ko05217 Basal cell carcinoma 2/842 68/7206 0.0209276308852 ko03015 mRNA surveillance pathway 4/842 93/7206 0.0219843458233 ko04014 Ras signaling pathway 45/842 279/7206 0.0222920746453 ko04919 Thyroid hormone signaling pathway 26/842 143/7206 0.0241793017141 ko04141 Protein processing in endoplasmic reticulum 12/842 184/7206 0.026523713816 ko05169 Epstein-Barr virus infection 14/842 206/7206 0.0270412862178 ko00010 Glycolysis / Gluconeogenesis 15/842 74/7206 0.0280275630987 ko05130 Pathogenic Escherichia coli infection 3/842 77/7206 0.0306741773046 ko04744 Phototransduction 9/842 36/7206 0.0311411422743 ko04371 Apelin signaling pathway 30/842 177/7206 0.0325796023234 ko04611 Platelet activation 28/842 163/7206 0.0350772555082 ko03420 Nucleotide excision repair 1/842 46/7206 0.0378069989754 ko05219 Bladder cancer 1/842 48/7206 0.0387778749663 ko04650 Natural killer cell mediated cytotoxicity 18/842 97/7206 0.0388868664679 ko05100 Bacterial invasion of epithelial cells 5/842 99/7206 0.0391466324249 ko00360 Phenylalanine metabolism 5/842 17/7206 0.0401673787888 ko00230 Purine metabolism 32/842 194/7206 0.0408523492448 ko05220 Chronic myeloid leukemia 4/842 85/7206 0.0410585985206 ko04657 IL-17 signaling pathway 4/842 87/7206 0.0417717091866 ko04214 Apoptosis - fly 3/842 72/7206 0.0422715543754 ko00562 Inositol phosphate metabolism 17/842 89/7206 0.0437417465791 ko00561 Glycerolipid metabolism 13/842 63/7206 0.0450178687291 ko00350 Tyrosine metabolism 8/842 33/7206 0.0490325930079