ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 34/271 191/7206 1.37627344125e-14 ko04380 Osteoclast differentiation 24/271 134/7206 1.15628152667e-10 ko04650 Natural killer cell mediated cytotoxicity 19/271 97/7206 2.26348118297e-09 ko05340 Primary immunodeficiency 10/271 30/7206 7.40465052539e-08 ko05152 Tuberculosis 23/271 187/7206 4.44173406846e-07 ko05150 Staphylococcus aureus infection 10/271 36/7206 5.12702513453e-07 ko05140 Leishmaniasis 14/271 75/7206 5.78280142956e-07 ko04660 T cell receptor signaling pathway 18/271 124/7206 7.28862239347e-07 ko05321 Inflammatory bowel disease (IBD) 12/271 56/7206 7.9864741666e-07 ko04659 Th17 cell differentiation 16/271 106/7206 1.80125380161e-06 ko04621 NOD-like receptor signaling pathway 19/271 157/7206 5.88303902709e-06 ko04610 Complement and coagulation cascades 13/271 79/7206 6.44141990844e-06 ko04630 Jak-STAT signaling pathway 17/271 132/7206 7.96089266805e-06 ko05162 Measles 16/271 120/7206 9.43433490903e-06 ko04658 Th1 and Th2 cell differentiation 14/271 96/7206 1.21379068299e-05 ko04064 NF-kappa B signaling pathway 14/271 96/7206 1.21379068299e-05 ko05145 Toxoplasmosis 16/271 126/7206 1.77033700457e-05 ko05168 Herpes simplex infection 19/271 182/7206 4.90002896942e-05 ko05164 Influenza A 18/271 167/7206 5.08540622256e-05 ko04672 Intestinal immune network for IgA production 8/271 37/7206 5.3866865107e-05 ko05320 Autoimmune thyroid disease 7/271 29/7206 7.54075381416e-05 ko04620 Toll-like receptor signaling pathway 13/271 100/7206 8.55919001225e-05 ko04640 Hematopoietic cell lineage 10/271 64/7206 0.000120349741082 ko04611 Platelet activation 17/271 163/7206 0.000124183628396 ko05330 Allograft rejection 6/271 24/7206 0.000203260469931 ko05144 Malaria 8/271 45/7206 0.000231612974388 ko04145 Phagosome 16/271 162/7206 0.000366962727171 ko05133 Pertussis 11/271 87/7206 0.000383332976032 ko04662 B cell receptor signaling pathway 11/271 88/7206 0.000423764315682 ko04612 Antigen processing and presentation 10/271 77/7206 0.000566781056532 ko04666 Fc gamma R-mediated phagocytosis 13/271 122/7206 0.000631893754111 ko05034 Alcoholism 1/271 238/7206 0.00159408883155 ko05323 Rheumatoid arthritis 10/271 89/7206 0.00176848820342 ko04062 Chemokine signaling pathway 17/271 201/7206 0.00183520253259 ko05310 Asthma 4/271 17/7206 0.0031596284289 ko05142 Chagas disease (American trypanosomiasis) 12/271 130/7206 0.00346832563308 ko05132 Salmonella infection 10/271 98/7206 0.00362336946298 ko05332 Graft-versus-host disease 4/271 18/7206 0.00394379625206 ko04670 Leukocyte transendothelial migration 13/271 151/7206 0.00437303448799 ko00592 alpha-Linolenic acid metabolism 4/271 19/7206 0.00484984391553 ko05167 Kaposi's sarcoma-associated herpesvirus infection 15/271 191/7206 0.00601977957347 ko04217 Necroptosis 14/271 178/7206 0.00802120859015 ko04664 Fc epsilon RI signaling pathway 8/271 77/7206 0.00802577702881 ko04514 Cell adhesion molecules (CAMs) 11/271 130/7206 0.00959409697405 ko04728 Dopaminergic synapse 1/271 185/7206 0.0104134536924 ko05131 Shigellosis 8/271 82/7206 0.0115800039943 ko00590 Arachidonic acid metabolism 6/271 52/7206 0.0127612096364 ko05418 Fluid shear stress and atherosclerosis 13/271 173/7206 0.0144376881533 ko05161 Hepatitis B 13/271 173/7206 0.0144376881533 ko04723 Retrograde endocannabinoid signaling 1/271 175/7206 0.0150590740739 ko05416 Viral myocarditis 6/271 55/7206 0.0165562265098 ko04623 Cytosolic DNA-sensing pathway 5/271 41/7206 0.0179571247191 ko04140 Autophagy - animal 1/271 164/7206 0.0217469089368 ko04910 Insulin signaling pathway 1/271 172/7206 0.0226077193945 ko05016 Huntington's disease 2/271 215/7206 0.0261881527067 ko04144 Endocytosis 21/271 342/7206 0.0272534443201 ko04622 RIG-I-like receptor signaling pathway 6/271 62/7206 0.0282803206117 ko04940 Type I diabetes mellitus 4/271 32/7206 0.0307416309259 ko00120 Primary bile acid biosynthesis 3/271 20/7206 0.037351165559 ko04110 Cell cycle 1/271 145/7206 0.0451298716104 ko00982 Drug metabolism - cytochrome P450 4/271 37/7206 0.0488591231598 ko04150 mTOR signaling pathway 2/271 184/7206 0.0489600928857 ko04141 Protein processing in endoplasmic reticulum 2/271 184/7206 0.0489600928857 ko04146 Peroxisome 7/271 89/7206 0.0495565636668