ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 19/185 152/7206 8.86234746586e-09 ko04915 Estrogen signaling pathway 15/185 131/7206 1.10917704993e-06 ko05030 Cocaine addiction 11/185 73/7206 2.11042586408e-06 ko05032 Morphine addiction 13/185 110/7206 4.1502774954e-06 ko04010 MAPK signaling pathway 23/185 321/7206 6.84268888603e-06 ko04713 Circadian entrainment 14/185 136/7206 9.06595514996e-06 ko04728 Dopaminergic synapse 16/185 185/7206 1.93093302944e-05 ko04923 Regulation of lipolysis in adipocytes 10/185 77/7206 2.40635063307e-05 ko04022 cGMP-PKG signaling pathway 17/185 216/7206 3.5968738013e-05 ko04911 Insulin secretion 12/185 117/7206 4.18325570557e-05 ko04072 Phospholipase D signaling pathway 16/185 197/7206 4.20161181525e-05 ko04020 Calcium signaling pathway 19/185 265/7206 4.52199171932e-05 ko04912 GnRH signaling pathway 12/185 122/7206 6.33531917375e-05 ko04261 Adrenergic signaling in cardiomyocytes 16/185 205/7206 6.80398169326e-05 ko04211 Longevity regulating pathway 12/185 123/7206 6.86497309396e-05 ko04925 Aldosterone synthesis and secretion 11/185 105/7206 7.23331055141e-05 ko04024 cAMP signaling pathway 19/185 279/7206 9.07971880518e-05 ko05031 Amphetamine addiction 10/185 91/7206 0.000103306867671 ko04727 GABAergic synapse 11/185 110/7206 0.00011072565226 ko04742 Taste transduction 8/185 61/7206 0.000149134463536 ko04723 Retrograde endocannabinoid signaling 14/185 175/7206 0.000150989670366 ko04720 Long-term potentiation 10/185 99/7206 0.000209712894921 ko04725 Cholinergic synapse 13/185 160/7206 0.000223661787365 ko04213 Longevity regulating pathway - multiple species 9/185 86/7206 0.000333900271317 ko04540 Gap junction 11/185 128/7206 0.000423349642507 ko05033 Nicotine addiction 7/185 56/7206 0.000525364494749 ko05231 Choline metabolism in cancer 11/185 134/7206 0.000625816411789 ko04080 Neuroactive ligand-receptor interaction 23/185 423/7206 0.000634507086102 ko01522 Endocrine resistance 10/185 124/7206 0.00126336594697 ko04914 Progesterone-mediated oocyte maturation 9/185 104/7206 0.00134313247605 ko01521 EGFR tyrosine kinase inhibitor resistance 9/185 106/7206 0.00153645444397 ko04012 ErbB signaling pathway 9/185 109/7206 0.00186780096327 ko04011 MAPK signaling pathway - yeast 6/185 53/7206 0.00222429697738 ko04070 Phosphatidylinositol signaling system 9/185 112/7206 0.0022540429991 ko04360 Axon guidance 14/185 233/7206 0.00259330218154 ko00515 Mannose type O-glycan biosynthesis 4/185 25/7206 0.00348648298814 ko04666 Fc gamma R-mediated phagocytosis 9/185 122/7206 0.00402033367805 ko05213 Endometrial cancer 6/185 62/7206 0.00492559919713 ko04371 Apelin signaling pathway 11/185 177/7206 0.00572282514057 ko04270 Vascular smooth muscle contraction 10/185 154/7206 0.00613469504832 ko05210 Colorectal cancer 7/185 86/7206 0.00639058436236 ko04918 Thyroid hormone synthesis 7/185 86/7206 0.00639058436236 ko00562 Inositol phosphate metabolism 7/185 89/7206 0.00768650000446 ko04320 Dorso-ventral axis formation 4/185 31/7206 0.00769469132183 ko05414 Dilated cardiomyopathy 8/185 112/7206 0.00794581345782 ko04970 Salivary secretion 7/185 95/7206 0.0108474132295 ko04921 Oxytocin signaling pathway 12/185 209/7206 0.0114069024849 ko05166 HTLV-I infection 15/185 292/7206 0.011815596286 ko04930 Type II diabetes mellitus 5/185 54/7206 0.0120844759548 ko04062 Chemokine signaling pathway 11/185 201/7206 0.0191716606142 ko05034 Alcoholism 12/185 238/7206 0.0210980971782 ko00513 Various types of N-glycan biosynthesis 4/185 42/7206 0.0220199157137 ko04913 Ovarian steroidogenesis 5/185 63/7206 0.0223519821044 ko04972 Pancreatic secretion 7/185 111/7206 0.0237443593098 ko04917 Prolactin signaling pathway 6/185 87/7206 0.0239757157872 ko04726 Serotonergic synapse 8/185 137/7206 0.0244031334055 ko04015 Rap1 signaling pathway 13/185 278/7206 0.0317627263004 ko04014 Ras signaling pathway 13/185 279/7206 0.0323193085937 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/185 28/7206 0.034059500344 ko04144 Endocytosis 15/185 342/7206 0.0354713085638 ko00512 Mucin type O-glycan biosynthesis 3/185 29/7206 0.0372920546844 ko04611 Platelet activation 9/185 163/7206 0.0378978435359 ko04140 Autophagy - animal 9/185 164/7206 0.038394066081 ko00510 N-Glycan biosynthesis 4/185 50/7206 0.0387301072303 ko04971 Gastric acid secretion 6/185 98/7206 0.0397865918992 ko00514 Other types of O-glycan biosynthesis 3/185 30/7206 0.040676011722 ko05014 Amyotrophic lateral sclerosis (ALS) 5/185 74/7206 0.0409913898106 ko00564 Glycerophospholipid metabolism 6/185 99/7206 0.0414875239808 ko04910 Insulin signaling pathway 9/185 172/7206 0.0434752825542 ko04730 Long-term depression 5/185 78/7206 0.0495605435374