ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1131	423/7206	2.15842688753e-41
ko04724	Glutamatergic synapse	88/1131	152/7206	2.12968481061e-33
ko05033	Nicotine addiction	49/1131	56/7206	1.21131876911e-32
ko05032	Morphine addiction	70/1131	110/7206	2.26020434181e-30
ko04727	GABAergic synapse	68/1131	110/7206	2.0635920641e-28
ko04713	Circadian entrainment	70/1131	136/7206	1.23706167963e-22
ko04728	Dopaminergic synapse	81/1131	185/7206	2.94161788692e-20
ko04723	Retrograde endocannabinoid signaling	78/1131	175/7206	4.04078740622e-20
ko04725	Cholinergic synapse	72/1131	160/7206	6.11354328802e-19
ko04721	Synaptic vesicle cycle	42/1131	80/7206	1.8788245188e-14
ko04024	cAMP signaling pathway	94/1131	279/7206	2.83686468283e-14
ko04744	Phototransduction	26/1131	36/7206	4.92899554837e-14
ko04020	Calcium signaling pathway	89/1131	265/7206	1.87773753254e-13
ko04726	Serotonergic synapse	57/1131	137/7206	2.00112634147e-13
ko04742	Taste transduction	33/1131	61/7206	4.12294863766e-12
ko04911	Insulin secretion	49/1131	117/7206	7.60074348136e-12
ko04921	Oxytocin signaling pathway	69/1131	209/7206	2.49647235542e-10
ko04261	Adrenergic signaling in cardiomyocytes	68/1131	205/7206	2.85061310072e-10
ko03040	Spliceosome	1/1131	145/7206	8.71544193439e-10
ko05031	Amphetamine addiction	38/1131	91/7206	1.94075580877e-09
ko04740	Olfactory transduction	34/1131	80/7206	8.04184546593e-09
ko05203	Viral carcinogenesis	13/1131	277/7206	9.71920194492e-09
ko05030	Cocaine addiction	31/1131	73/7206	3.76560804224e-08
ko04720	Long-term potentiation	37/1131	99/7206	1.47121140104e-07
ko04970	Salivary secretion	35/1131	95/7206	4.34394780155e-07
ko04925	Aldosterone synthesis and secretion	37/1131	105/7206	8.96899092802e-07
ko05322	Systemic lupus erythematosus	5/1131	151/7206	1.35426988147e-06
ko04971	Gastric acid secretion	34/1131	98/7206	3.49843011327e-06
ko03013	RNA transport	7/1131	166/7206	4.14290090268e-06
ko04972	Pancreatic secretion	36/1131	111/7206	8.95311396606e-06
ko04072	Phospholipase D signaling pathway	55/1131	197/7206	9.47116704527e-06
ko04060	Cytokine-cytokine receptor interaction	10/1131	191/7206	1.09795207681e-05
ko05164	Influenza A	8/1131	167/7206	1.340655827e-05
ko04514	Cell adhesion molecules (CAMs)	40/1131	130/7206	1.36544163721e-05
ko04022	cGMP-PKG signaling pathway	58/1131	216/7206	2.3329203471e-05
ko04621	NOD-like receptor signaling pathway	8/1131	157/7206	5.26857385089e-05
ko04110	Cell cycle	7/1131	145/7206	6.97109503645e-05
ko04141	Protein processing in endoplasmic reticulum	11/1131	184/7206	7.92611723951e-05
ko04070	Phosphatidylinositol signaling system	34/1131	112/7206	0.000105357843971
ko04360	Axon guidance	59/1131	233/7206	0.000107692636139
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1131	79/7206	0.000126110954994
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1131	74/7206	0.000133876490807
ko04976	Bile secretion	26/1131	80/7206	0.000151040853134
ko04120	Ubiquitin mediated proteolysis	7/1131	138/7206	0.000200353088209
ko04711	Circadian rhythm - fly	8/1131	13/7206	0.000220707391436
ko03008	Ribosome biogenesis in eukaryotes	2/1131	79/7206	0.000266313326858
ko05168	Herpes simplex infection	12/1131	182/7206	0.000267041155591
ko04010	MAPK signaling pathway	75/1131	321/7206	0.000280729176962
ko04745	Phototransduction - fly	15/1131	38/7206	0.000341340306061
ko04612	Antigen processing and presentation	2/1131	77/7206	0.000398221077433
ko05169	Epstein-Barr virus infection	15/1131	206/7206	0.000416748786059
ko05205	Proteoglycans in cancer	23/1131	271/7206	0.000462067265194
ko04710	Circadian rhythm	16/1131	43/7206	0.000480190806865
ko05162	Measles	6/1131	120/7206	0.000522790961587
ko04064	NF-kappa B signaling pathway	4/1131	96/7206	0.000601677780541
ko05140	Leishmaniasis	2/1131	75/7206	0.000602173353065
ko05161	Hepatitis B	12/1131	173/7206	0.000654110765263
ko04730	Long-term depression	24/1131	78/7206	0.000782237214525
ko04260	Cardiac muscle contraction	28/1131	98/7206	0.00109885550681
ko00520	Amino sugar and nucleotide sugar metabolism	1/1131	55/7206	0.00135203643322
ko04610	Complement and coagulation cascades	3/1131	79/7206	0.00156905559968
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1131	59/7206	0.00166539311782
ko05016	Huntington's disease	18/1131	215/7206	0.00216783698907
ko05414	Dilated cardiomyopathy	30/1131	112/7206	0.00234641384611
ko04640	Hematopoietic cell lineage	2/1131	64/7206	0.00278075166864
ko04964	Proximal tubule bicarbonate reclamation	11/1131	29/7206	0.00304942014104
ko03018	RNA degradation	4/1131	84/7206	0.00361702484459
ko04966	Collecting duct acid secretion	10/1131	26/7206	0.00416205337645
ko04210	Apoptosis	15/1131	180/7206	0.00482203944003
ko04750	Inflammatory mediator regulation of TRP channels	31/1131	122/7206	0.00531381482097
ko04217	Necroptosis	15/1131	178/7206	0.00632295936997
ko05144	Malaria	1/1131	45/7206	0.00682593286935
ko03420	Nucleotide excision repair	1/1131	46/7206	0.00693448940835
ko04658	Th1 and Th2 cell differentiation	6/1131	96/7206	0.007031952154
ko04924	Renin secretion	23/1131	86/7206	0.00708599236744
ko04657	IL-17 signaling pathway	5/1131	87/7206	0.00714017416179
ko05133	Pertussis	5/1131	87/7206	0.00714017416179
ko04630	Jak-STAT signaling pathway	10/1131	132/7206	0.00753805332281
ko04930	Type II diabetes mellitus	16/1131	54/7206	0.00807503782331
ko05110	Vibrio cholerae infection	18/1131	63/7206	0.00830712041694
ko04371	Apelin signaling pathway	41/1131	177/7206	0.00855213888588
ko05321	Inflammatory bowel disease (IBD)	2/1131	56/7206	0.0086644930424
ko05012	Parkinson's disease	13/1131	155/7206	0.00986034660912
ko04115	p53 signaling pathway	4/1131	74/7206	0.00988162505582
ko04915	Estrogen signaling pathway	32/1131	131/7206	0.0102679656921
ko03022	Basal transcription factors	1/1131	44/7206	0.0106395467831
ko04510	Focal adhesion	24/1131	240/7206	0.01144782304
ko00590	Arachidonic acid metabolism	2/1131	52/7206	0.0124199051144
ko04142	Lysosome	13/1131	151/7206	0.0127223246404
ko05145	Toxoplasmosis	10/1131	126/7206	0.0131179882372
ko04622	RIG-I-like receptor signaling pathway	3/1131	62/7206	0.013489700804
ko05166	HTLV-I infection	31/1131	292/7206	0.0135866572939
ko00290	Valine, leucine and isoleucine biosynthesis	3/1131	4/7206	0.0136185801531
ko05131	Shigellosis	5/1131	82/7206	0.0137087225892
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1131	14/7206	0.0142531728414
ko04918	Thyroid hormone synthesis	22/1131	86/7206	0.0162532131375
ko04140	Autophagy - animal	15/1131	164/7206	0.0168166640456
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1131	182/7206	0.0170735409865
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1131	100/7206	0.0174799340343
ko04923	Regulation of lipolysis in adipocytes	20/1131	77/7206	0.0175655743595
ko04540	Gap junction	30/1131	128/7206	0.0194472804693
ko04218	Cellular senescence	17/1131	177/7206	0.0213292071342
ko05231	Choline metabolism in cancer	31/1131	134/7206	0.0221560667959
ko00630	Glyoxylate and dicarboxylate metabolism	1/1131	38/7206	0.0229786575352
ko03410	Base excision repair	1/1131	38/7206	0.0229786575352
ko05215	Prostate cancer	9/1131	111/7206	0.0248709105744
ko05219	Bladder cancer	2/1131	48/7206	0.0263655140399
ko00562	Inositol phosphate metabolism	22/1131	89/7206	0.0265635915271
ko04014	Ras signaling pathway	57/1131	279/7206	0.0291417167617
ko00240	Pyrimidine metabolism	9/1131	110/7206	0.0332839612933
ko00860	Porphyrin and chlorophyll metabolism	1/1131	34/7206	0.0338050879308
ko00500	Starch and sucrose metabolism	1/1131	35/7206	0.0338935854604
ko04620	Toll-like receptor signaling pathway	8/1131	100/7206	0.0365196880191
ko00071	Fatty acid degradation	2/1131	45/7206	0.0376790211806
ko00280	Valine, leucine and isoleucine degradation	3/1131	54/7206	0.037964717431
ko00480	Glutathione metabolism	3/1131	55/7206	0.0384852084862
ko02010	ABC transporters	11/1131	39/7206	0.0438078470725
ko00230	Purine metabolism	41/1131	194/7206	0.0446159142817
ko04113	Meiosis - yeast	5/1131	70/7206	0.0472536230699
ko04810	Regulation of actin cytoskeleton	30/1131	264/7206	0.0475642621076
ko04214	Apoptosis - fly	5/1131	72/7206	0.0484983792579
ko04978	Mineral absorption	11/1131	40/7206	0.0487154437233