ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 152/931 423/7206 3.66166335336e-36 ko04724 Glutamatergic synapse 73/931 152/7206 1.52590628519e-26 ko05033 Nicotine addiction 40/931 56/7206 7.06074394608e-24 ko04721 Synaptic vesicle cycle 44/931 80/7206 2.20367336951e-19 ko04728 Dopaminergic synapse 70/931 185/7206 3.03621049974e-18 ko04713 Circadian entrainment 58/931 136/7206 3.58192902494e-18 ko05032 Morphine addiction 51/931 110/7206 5.14672979029e-18 ko04727 GABAergic synapse 48/931 110/7206 1.01432938422e-15 ko04723 Retrograde endocannabinoid signaling 61/931 175/7206 4.07766741862e-14 ko04725 Cholinergic synapse 56/931 160/7206 3.85278318702e-13 ko04020 Calcium signaling pathway 77/931 265/7206 1.797867696e-12 ko05031 Amphetamine addiction 38/931 91/7206 5.4683476111e-12 ko04726 Serotonergic synapse 48/931 137/7206 1.8518383013e-11 ko04024 cAMP signaling pathway 77/931 279/7206 2.93692316701e-11 ko04911 Insulin secretion 43/931 117/7206 3.54781456058e-11 ko04921 Oxytocin signaling pathway 62/931 209/7206 8.11893572156e-11 ko04720 Long-term potentiation 35/931 99/7206 7.9495854306e-09 ko04970 Salivary secretion 33/931 95/7206 3.50085364759e-08 ko04742 Taste transduction 25/931 61/7206 3.83991390313e-08 ko04261 Adrenergic signaling in cardiomyocytes 54/931 205/7206 1.35492150988e-07 ko03010 Ribosome 1/931 129/7206 4.60424074365e-07 ko04744 Phototransduction 17/931 36/7206 5.22236325467e-07 ko05030 Cocaine addiction 26/931 73/7206 5.69849453765e-07 ko04966 Collecting duct acid secretion 14/931 26/7206 7.02967958352e-07 ko03040 Spliceosome 2/931 145/7206 9.63167857267e-07 ko04120 Ubiquitin mediated proteolysis 2/931 138/7206 2.06199787611e-06 ko05322 Systemic lupus erythematosus 3/931 151/7206 3.26915368409e-06 ko04971 Gastric acid secretion 30/931 98/7206 4.30062196014e-06 ko04925 Aldosterone synthesis and secretion 31/931 105/7206 5.44011004233e-06 ko05203 Viral carcinogenesis 13/931 277/7206 5.84844740021e-06 ko05168 Herpes simplex infection 6/931 182/7206 9.71400230335e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 24/931 74/7206 1.00922956029e-05 ko04745 Phototransduction - fly 15/931 38/7206 3.56465810844e-05 ko04514 Cell adhesion molecules (CAMs) 34/931 130/7206 5.04257286482e-05 ko04060 Cytokine-cytokine receptor interaction 8/931 191/7206 6.67694462731e-05 ko04022 cGMP-PKG signaling pathway 49/931 216/7206 7.35987154391e-05 ko04730 Long-term depression 23/931 78/7206 0.000103095837725 ko04360 Axon guidance 51/931 233/7206 0.000136143597064 ko04621 NOD-like receptor signaling pathway 6/931 157/7206 0.000158131606862 ko05164 Influenza A 7/931 167/7206 0.00024286246726 ko05110 Vibrio cholerae infection 19/931 63/7206 0.000404488333445 ko04540 Gap junction 31/931 128/7206 0.000437407211045 ko04010 MAPK signaling pathway 63/931 321/7206 0.000609743864619 ko04972 Pancreatic secretion 27/931 111/7206 0.00087765863922 ko03013 RNA transport 8/931 166/7206 0.000906787287518 ko04070 Phosphatidylinositol signaling system 27/931 112/7206 0.000971314705156 ko04626 Plant-pathogen interaction 8/931 18/7206 0.000995588899299 ko04141 Protein processing in endoplasmic reticulum 10/931 184/7206 0.00113518424775 ko04110 Cell cycle 7/931 145/7206 0.00163958366633 ko04924 Renin secretion 22/931 86/7206 0.00166145275653 ko05166 HTLV-I infection 21/931 292/7206 0.00178512455457 ko04064 NF-kappa B signaling pathway 3/931 96/7206 0.00184515009824 ko04014 Ras signaling pathway 54/931 279/7206 0.00187379796662 ko03008 Ribosome biogenesis in eukaryotes 2/931 79/7206 0.00217814240802 ko05205 Proteoglycans in cancer 19/931 271/7206 0.00219589022385 ko05162 Measles 5/931 120/7206 0.00221670200145 ko04964 Proximal tubule bicarbonate reclamation 10/931 29/7206 0.00243173734011 ko05161 Hepatitis B 10/931 173/7206 0.00272405989262 ko04612 Antigen processing and presentation 2/931 77/7206 0.00317706484817 ko04330 Notch signaling pathway 1/931 62/7206 0.00355291568491 ko04750 Inflammatory mediator regulation of TRP channels 27/931 122/7206 0.00399562971062 ko04922 Glucagon signaling pathway 28/931 128/7206 0.00473084155188 ko05140 Leishmaniasis 2/931 75/7206 0.00474499127399 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/931 14/7206 0.00546406949439 ko04915 Estrogen signaling pathway 28/931 131/7206 0.00563423039051 ko04630 Jak-STAT signaling pathway 7/931 132/7206 0.00564592781913 ko05169 Epstein-Barr virus infection 14/931 206/7206 0.00592305596555 ko04740 Olfactory transduction 19/931 80/7206 0.00672487357126 ko04214 Apoptosis - fly 2/931 72/7206 0.00691259697144 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/931 92/7206 0.00736978539578 ko05321 Inflammatory bowel disease (IBD) 1/931 56/7206 0.00788573412643 ko04072 Phospholipase D signaling pathway 38/931 197/7206 0.00952162257565 ko00590 Arachidonic acid metabolism 1/931 52/7206 0.0114531835478 ko04011 MAPK signaling pathway - yeast 1/931 53/7206 0.0117289704911 ko04930 Type II diabetes mellitus 14/931 54/7206 0.0122458322979 ko05016 Huntington's disease 16/931 215/7206 0.0129565026178 ko00240 Pyrimidine metabolism 6/931 110/7206 0.0145192200133 ko01524 Platinum drug resistance 3/931 76/7206 0.0150196364772 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/931 79/7206 0.0164459095087 ko05219 Bladder cancer 1/931 48/7206 0.0168469386242 ko04510 Focal adhesion 19/931 240/7206 0.0183602696917 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/931 59/7206 0.0187430140233 ko04710 Circadian rhythm 11/931 43/7206 0.0206332672262 ko00071 Fatty acid degradation 1/931 45/7206 0.0248386981159 ko03420 Nucleotide excision repair 1/931 46/7206 0.0251025927898 ko04550 Signaling pathways regulating pluripotency of stem cells 12/931 165/7206 0.0255664476394 ko04114 Oocyte meiosis 27/931 139/7206 0.0288967772551 ko04371 Apelin signaling pathway 33/931 177/7206 0.0301727880112 ko05200 Pathways in cancer 48/931 492/7206 0.0306845451919 ko05215 Prostate cancer 7/931 111/7206 0.0324083069608 ko04260 Cardiac muscle contraction 20/931 98/7206 0.0329489430078 ko04960 Aldosterone-regulated sodium reabsorption 10/931 41/7206 0.0357741055523 ko00983 Drug metabolism - other enzymes 1/931 42/7206 0.0365730562079 ko04146 Peroxisome 5/931 89/7206 0.0377464011642 ko05222 Small cell lung cancer 5/931 89/7206 0.0377464011642 ko00280 Valine, leucine and isoleucine degradation 2/931 54/7206 0.0404313094107 ko04610 Complement and coagulation cascades 4/931 79/7206 0.0407145237858 ko00480 Glutathione metabolism 2/931 55/7206 0.0409618244752 ko04210 Apoptosis 14/931 180/7206 0.0418168121083 ko05010 Alzheimer's disease 36/931 202/7206 0.0425400979044