ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 36/371 134/7206 4.58232749903e-17 ko04060 Cytokine-cytokine receptor interaction 37/371 191/7206 1.18895071848e-12 ko04064 NF-kappa B signaling pathway 24/371 96/7206 4.964152092e-11 ko04621 NOD-like receptor signaling pathway 31/371 157/7206 5.30192643867e-11 ko05164 Influenza A 29/371 167/7206 5.3128781261e-09 ko04668 TNF signaling pathway 24/371 120/7206 6.58764932891e-09 ko04660 T cell receptor signaling pathway 24/371 124/7206 1.30241741344e-08 ko04650 Natural killer cell mediated cytotoxicity 20/371 97/7206 7.24928334524e-08 ko05321 Inflammatory bowel disease (IBD) 15/371 56/7206 8.37557901454e-08 ko04620 Toll-like receptor signaling pathway 20/371 100/7206 1.23676143908e-07 ko05144 Malaria 13/371 45/7206 2.35163465869e-07 ko04658 Th1 and Th2 cell differentiation 19/371 96/7206 3.05556875319e-07 ko04512 ECM-receptor interaction 17/371 79/7206 3.68971484713e-07 ko05161 Hepatitis B 26/371 173/7206 6.63129077283e-07 ko05140 Leishmaniasis 16/371 75/7206 9.2559066121e-07 ko05340 Primary immunodeficiency 10/371 30/7206 1.37988500669e-06 ko05133 Pertussis 17/371 87/7206 1.56224734348e-06 ko05323 Rheumatoid arthritis 17/371 89/7206 2.17680929324e-06 ko04622 RIG-I-like receptor signaling pathway 14/371 62/7206 2.17993975565e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/371 135/7206 4.61797285394e-06 ko05145 Toxoplasmosis 20/371 126/7206 5.69260319957e-06 ko05168 Herpes simplex infection 25/371 182/7206 5.83028134006e-06 ko04659 Th17 cell differentiation 18/371 106/7206 6.3597248187e-06 ko04610 Complement and coagulation cascades 15/371 79/7206 9.36306071364e-06 ko05152 Tuberculosis 25/371 187/7206 9.4930344506e-06 ko05162 Measles 19/371 120/7206 1.01399595388e-05 ko04630 Jak-STAT signaling pathway 20/371 132/7206 1.17105936221e-05 ko04623 Cytosolic DNA-sensing pathway 10/371 41/7206 3.0937240858e-05 ko04657 IL-17 signaling pathway 15/371 87/7206 3.1338428818e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/371 191/7206 4.06694900206e-05 ko04210 Apoptosis 23/371 180/7206 4.51134709109e-05 ko05150 Staphylococcus aureus infection 9/371 36/7206 6.28323857412e-05 ko04672 Intestinal immune network for IgA production 9/371 37/7206 7.93109379107e-05 ko05166 HTLV-I infection 31/371 292/7206 0.000110603407733 ko04510 Focal adhesion 27/371 240/7206 0.000132191019436 ko04662 B cell receptor signaling pathway 14/371 88/7206 0.000141890418457 ko04666 Fc gamma R-mediated phagocytosis 17/371 122/7206 0.000154512699048 ko05131 Shigellosis 13/371 82/7206 0.000253227843063 ko05142 Chagas disease (American trypanosomiasis) 17/371 130/7206 0.000336095546909 ko04217 Necroptosis 21/371 178/7206 0.00037290236067 ko05034 Alcoholism 2/371 238/7206 0.000495203439338 ko04611 Platelet activation 19/371 163/7206 0.000835198133168 ko04062 Chemokine signaling pathway 22/371 201/7206 0.00087754141634 ko04670 Leukocyte transendothelial migration 18/371 151/7206 0.00102178264564 ko05330 Allograft rejection 6/371 24/7206 0.001090735207 ko05160 Hepatitis C 18/371 153/7206 0.00110990700423 ko05132 Salmonella infection 13/371 98/7206 0.00144699401054 ko04640 Hematopoietic cell lineage 10/371 64/7206 0.00145116247183 ko05016 Huntington's disease 2/371 215/7206 0.00147767717398 ko05418 Fluid shear stress and atherosclerosis 19/371 173/7206 0.00148012066783 ko05332 Graft-versus-host disease 5/371 18/7206 0.00172809208192 ko05222 Small cell lung cancer 12/371 89/7206 0.00189484447527 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/371 92/7206 0.00252119605151 ko05320 Autoimmune thyroid disease 6/371 29/7206 0.00309548352104 ko05200 Pathways in cancer 40/371 492/7206 0.0040224273677 ko05134 Legionellosis 10/371 74/7206 0.00436019361683 ko05146 Amoebiasis 12/371 99/7206 0.00465042198497 ko04724 Glutamatergic synapse 1/371 152/7206 0.00480651606667 ko04145 Phagosome 17/371 162/7206 0.00565871319347 ko04810 Regulation of actin cytoskeleton 24/371 264/7206 0.00634643266281 ko04713 Circadian entrainment 1/371 136/7206 0.0101344540936 ko04114 Oocyte meiosis 1/371 139/7206 0.0102800356644 ko04916 Melanogenesis 1/371 142/7206 0.0106959372249 ko05202 Transcriptional misregulation in cancer 18/371 188/7206 0.0107377005094 ko01200 Carbon metabolism 1/371 128/7206 0.0146788330774 ko04612 Antigen processing and presentation 9/371 77/7206 0.0168012461397 ko04550 Signaling pathways regulating pluripotency of stem cells 2/371 165/7206 0.0182970544844 ko04072 Phospholipase D signaling pathway 18/371 197/7206 0.020074441502 ko04940 Type I diabetes mellitus 5/371 32/7206 0.0225003444109 ko05143 African trypanosomiasis 5/371 32/7206 0.0225003444109 ko04144 Endocytosis 27/371 342/7206 0.0235921864042 ko04911 Insulin secretion 1/371 117/7206 0.0314830365541 ko05205 Proteoglycans in cancer 22/371 271/7206 0.0339740165386 ko05410 Hypertrophic cardiomyopathy (HCM) 10/371 100/7206 0.0373245498302 ko05212 Pancreatic cancer 9/371 83/7206 0.0383095082318 ko04932 Non-alcoholic fatty liver disease (NAFLD) 16/371 182/7206 0.0385609717124 ko04514 Cell adhesion molecules (CAMs) 12/371 130/7206 0.0430721370229 ko04917 Prolactin signaling pathway 9/371 87/7206 0.04399553072 ko04914 Progesterone-mediated oocyte maturation 1/371 104/7206 0.0440675101971 ko04727 GABAergic synapse 1/371 110/7206 0.0457539585079 ko04972 Pancreatic secretion 1/371 111/7206 0.0464108087932 ko04726 Serotonergic synapse 2/371 137/7206 0.0485013331024 ko00590 Arachidonic acid metabolism 6/371 52/7206 0.0494546280322