ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1196	423/7206	2.92613633922e-53
ko04724	Glutamatergic synapse	89/1196	152/7206	2.38383765732e-32
ko05033	Nicotine addiction	47/1196	56/7206	1.6608078736e-28
ko05032	Morphine addiction	68/1196	110/7206	6.62574888256e-27
ko04713	Circadian entrainment	77/1196	136/7206	9.22534514608e-27
ko04727	GABAergic synapse	63/1196	110/7206	1.89067685432e-22
ko04020	Calcium signaling pathway	106/1196	265/7206	1.71278600863e-20
ko04721	Synaptic vesicle cycle	50/1196	80/7206	2.21508872378e-20
ko04725	Cholinergic synapse	76/1196	160/7206	3.47521014976e-20
ko04728	Dopaminergic synapse	83/1196	185/7206	5.84371269637e-20
ko04723	Retrograde endocannabinoid signaling	77/1196	175/7206	5.54552725862e-18
ko04024	cAMP signaling pathway	105/1196	279/7206	6.27967110531e-18
ko04911	Insulin secretion	57/1196	117/7206	4.70660576417e-16
ko04921	Oxytocin signaling pathway	83/1196	209/7206	5.09148933154e-16
ko04742	Taste transduction	38/1196	61/7206	1.02201841633e-15
ko04726	Serotonergic synapse	59/1196	137/7206	1.50228717692e-13
ko04970	Salivary secretion	45/1196	95/7206	2.15000970458e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1196	205/7206	6.3847383638e-12
ko04720	Long-term potentiation	45/1196	99/7206	1.28971277968e-11
ko05031	Amphetamine addiction	41/1196	91/7206	1.49329640169e-10
ko04022	cGMP-PKG signaling pathway	72/1196	216/7206	1.1197157601e-09
ko03040	Spliceosome	2/1196	145/7206	2.53062835026e-09
ko04740	Olfactory transduction	35/1196	80/7206	8.65567188709e-09
ko04360	Axon guidance	74/1196	233/7206	8.76674429003e-09
ko05203	Viral carcinogenesis	15/1196	277/7206	1.38363304989e-08
ko04744	Phototransduction	21/1196	36/7206	1.58174404971e-08
ko04925	Aldosterone synthesis and secretion	41/1196	105/7206	3.06104245278e-08
ko05168	Herpes simplex infection	7/1196	182/7206	9.36735279248e-08
ko04971	Gastric acid secretion	38/1196	98/7206	1.2140871112e-07
ko04060	Cytokine-cytokine receptor interaction	8/1196	191/7206	1.70078806e-07
ko05322	Systemic lupus erythematosus	5/1196	151/7206	3.81682591567e-07
ko05164	Influenza A	7/1196	167/7206	8.69911859274e-07
ko04924	Renin secretion	33/1196	86/7206	1.10574405827e-06
ko03013	RNA transport	7/1196	166/7206	1.28326486592e-06
ko04540	Gap junction	43/1196	128/7206	1.86325623947e-06
ko05030	Cocaine addiction	29/1196	73/7206	1.89322678736e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1196	74/7206	1.00189946851e-05
ko04010	MAPK signaling pathway	84/1196	321/7206	1.02928927173e-05
ko04371	Apelin signaling pathway	52/1196	177/7206	2.08234861176e-05
ko04514	Cell adhesion molecules (CAMs)	41/1196	130/7206	2.21362749282e-05
ko05169	Epstein-Barr virus infection	14/1196	206/7206	3.69042746349e-05
ko04730	Long-term depression	28/1196	78/7206	3.81664276834e-05
ko04972	Pancreatic secretion	36/1196	111/7206	4.58727219533e-05
ko04621	NOD-like receptor signaling pathway	9/1196	157/7206	5.09709118704e-05
ko04120	Ubiquitin mediated proteolysis	7/1196	138/7206	6.57154161609e-05
ko04966	Collecting duct acid secretion	13/1196	26/7206	8.38516915133e-05
ko05414	Dilated cardiomyopathy	35/1196	112/7206	9.98745877592e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1196	79/7206	0.000109720893652
ko04745	Phototransduction - fly	16/1196	38/7206	0.000173368361794
ko04141	Protein processing in endoplasmic reticulum	13/1196	184/7206	0.000177664290923
ko04610	Complement and coagulation cascades	2/1196	79/7206	0.000177845251768
ko03008	Ribosome biogenesis in eukaryotes	2/1196	79/7206	0.000177845251768
ko04260	Cardiac muscle contraction	31/1196	98/7206	0.000188611520434
ko04976	Bile secretion	27/1196	80/7206	0.000194071043795
ko05205	Proteoglycans in cancer	24/1196	271/7206	0.000234955460913
ko05140	Leishmaniasis	2/1196	75/7206	0.000248816261235
ko04110	Cell cycle	9/1196	145/7206	0.000264742400354
ko04070	Phosphatidylinositol signaling system	34/1196	112/7206	0.000270909600482
ko04064	NF-kappa B signaling pathway	4/1196	96/7206	0.000272130094943
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1196	59/7206	0.000330283139076
ko05110	Vibrio cholerae infection	22/1196	63/7206	0.00044607793243
ko05161	Hepatitis B	13/1196	173/7206	0.000584538274207
ko04014	Ras signaling pathway	68/1196	279/7206	0.000717475715928
ko04915	Estrogen signaling pathway	37/1196	131/7206	0.000782274940049
ko04750	Inflammatory mediator regulation of TRP channels	35/1196	122/7206	0.000787377604374
ko04146	Peroxisome	4/1196	89/7206	0.000816719074799
ko04072	Phospholipase D signaling pathway	51/1196	197/7206	0.00087476857401
ko04626	Plant-pathogen interaction	9/1196	18/7206	0.00107876300334
ko04923	Regulation of lipolysis in adipocytes	24/1196	77/7206	0.00167596632306
ko05162	Measles	8/1196	120/7206	0.00181278338206
ko00240	Pyrimidine metabolism	7/1196	110/7206	0.0026376140216
ko00330	Arginine and proline metabolism	2/1196	61/7206	0.00269047275619
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1196	14/7206	0.00397245049664
ko00071	Fatty acid degradation	1/1196	45/7206	0.00435905669039
ko03420	Nucleotide excision repair	1/1196	46/7206	0.00442293561633
ko04964	Proximal tubule bicarbonate reclamation	11/1196	29/7206	0.00477023908869
ko01524	Platinum drug resistance	4/1196	76/7206	0.00479398860295
ko00480	Glutathione metabolism	2/1196	55/7206	0.0056326685501
ko04930	Type II diabetes mellitus	17/1196	54/7206	0.00563523479945
ko05321	Inflammatory bowel disease (IBD)	2/1196	56/7206	0.00580041763469
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1196	182/7206	0.00622368248799
ko00310	Lysine degradation	4/1196	73/7206	0.00675383195908
ko03022	Basal transcription factors	1/1196	44/7206	0.00678575486215
ko05166	HTLV-I infection	32/1196	292/7206	0.00784455281073
ko00590	Arachidonic acid metabolism	2/1196	52/7206	0.00820969150704
ko04270	Vascular smooth muscle contraction	38/1196	154/7206	0.00852438423231
ko00280	Valine, leucine and isoleucine degradation	2/1196	54/7206	0.00870486089734
ko04630	Jak-STAT signaling pathway	11/1196	132/7206	0.00889211534844
ko04330	Notch signaling pathway	3/1196	62/7206	0.00919951635259
ko04622	RIG-I-like receptor signaling pathway	3/1196	62/7206	0.00919951635259
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1196	100/7206	0.00934206838808
ko04214	Apoptosis - fly	4/1196	72/7206	0.00979743055291
ko04217	Necroptosis	17/1196	178/7206	0.0103384667464
ko00380	Tryptophan metabolism	2/1196	50/7206	0.0120226596766
ko04668	TNF signaling pathway	10/1196	120/7206	0.0127575398057
ko04657	IL-17 signaling pathway	6/1196	87/7206	0.0128381268953
ko05133	Pertussis	6/1196	87/7206	0.0128381268953
ko04612	Antigen processing and presentation	5/1196	77/7206	0.0131684268273
ko04912	GnRH signaling pathway	31/1196	122/7206	0.0133782425233
ko00562	Inositol phosphate metabolism	24/1196	89/7206	0.0137811686835
ko03410	Base excision repair	1/1196	38/7206	0.0147579923474
ko05145	Toxoplasmosis	11/1196	126/7206	0.0151624782018
ko04922	Glucagon signaling pathway	32/1196	128/7206	0.015753643977
ko03018	RNA degradation	6/1196	84/7206	0.01737454975
ko00260	Glycine, serine and threonine metabolism	2/1196	48/7206	0.0176947700673
ko04115	p53 signaling pathway	5/1196	74/7206	0.0181343311273
ko04620	Toll-like receptor signaling pathway	8/1196	100/7206	0.0203747352273
ko05222	Small cell lung cancer	7/1196	89/7206	0.0217894986037
ko04916	Melanogenesis	34/1196	142/7206	0.0222501180256
ko05131	Shigellosis	6/1196	82/7206	0.0238302555711
ko05144	Malaria	2/1196	45/7206	0.0253635944257
ko04210	Apoptosis	19/1196	180/7206	0.0254914429139
ko04015	Rap1 signaling pathway	60/1196	278/7206	0.0262678383249
ko04640	Hematopoietic cell lineage	4/1196	64/7206	0.0264747669778
ko04658	Th1 and Th2 cell differentiation	8/1196	96/7206	0.0265990925076
ko04114	Oocyte meiosis	33/1196	139/7206	0.0281365580282
ko05215	Prostate cancer	10/1196	111/7206	0.0284889832541
ko04213	Longevity regulating pathway - multiple species	22/1196	86/7206	0.0287975286324
ko05418	Fluid shear stress and atherosclerosis	18/1196	173/7206	0.0291643106339
ko03320	PPAR signaling pathway	5/1196	69/7206	0.0339680485458
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1196	135/7206	0.047513154197
ko05340	Primary immunodeficiency	1/1196	30/7206	0.0488194656014