ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1262	423/7206	7.95959916983e-58
ko04724	Glutamatergic synapse	93/1262	152/7206	5.38555099598e-34
ko05033	Nicotine addiction	49/1262	56/7206	2.50604448095e-30
ko04713	Circadian entrainment	80/1262	136/7206	1.09876344617e-27
ko05032	Morphine addiction	70/1262	110/7206	2.58956554886e-27
ko04727	GABAergic synapse	68/1262	110/7206	1.79595703426e-25
ko04721	Synaptic vesicle cycle	54/1262	80/7206	3.67366575496e-23
ko04728	Dopaminergic synapse	90/1262	185/7206	6.08674169574e-23
ko04725	Cholinergic synapse	80/1262	160/7206	1.85810461382e-21
ko04020	Calcium signaling pathway	108/1262	265/7206	1.37983714327e-19
ko04024	cAMP signaling pathway	111/1262	279/7206	3.20596791926e-19
ko04723	Retrograde endocannabinoid signaling	79/1262	175/7206	8.48301646541e-18
ko04911	Insulin secretion	60/1262	117/7206	4.71094431223e-17
ko04742	Taste transduction	40/1262	61/7206	8.63456803605e-17
ko04921	Oxytocin signaling pathway	86/1262	209/7206	4.02736095813e-16
ko04726	Serotonergic synapse	64/1262	137/7206	1.57123510661e-15
ko04970	Salivary secretion	49/1262	95/7206	2.77077870766e-14
ko04720	Long-term potentiation	50/1262	99/7206	4.45467395468e-14
ko04744	Phototransduction	27/1262	36/7206	5.44017455555e-14
ko05031	Amphetamine addiction	46/1262	91/7206	4.50654912886e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1262	205/7206	1.8569162058e-12
ko04740	Olfactory transduction	41/1262	80/7206	4.79436104837e-12
ko03040	Spliceosome	1/1262	145/7206	2.63475764802e-11
ko05168	Herpes simplex infection	6/1262	182/7206	4.22905472766e-09
ko04925	Aldosterone synthesis and secretion	44/1262	105/7206	4.7166957082e-09
ko04360	Axon guidance	77/1262	233/7206	6.31407225093e-09
ko05203	Viral carcinogenesis	16/1262	277/7206	6.31742342399e-09
ko04971	Gastric acid secretion	41/1262	98/7206	1.75871616784e-08
ko04022	cGMP-PKG signaling pathway	70/1262	216/7206	7.96333819116e-08
ko04060	Cytokine-cytokine receptor interaction	9/1262	191/7206	1.15989017918e-07
ko05030	Cocaine addiction	32/1262	73/7206	1.31620114769e-07
ko04540	Gap junction	47/1262	128/7206	1.97494154475e-07
ko03013	RNA transport	7/1262	166/7206	2.51603285377e-07
ko04924	Renin secretion	35/1262	86/7206	3.75731006614e-07
ko04730	Long-term depression	32/1262	78/7206	1.09532000374e-06
ko04141	Protein processing in endoplasmic reticulum	10/1262	184/7206	1.62986705977e-06
ko04010	MAPK signaling pathway	90/1262	321/7206	1.79908083107e-06
ko05322	Systemic lupus erythematosus	7/1262	151/7206	2.33956186176e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1262	59/7206	6.545691536e-06
ko04610	Complement and coagulation cascades	1/1262	79/7206	7.82830563356e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1262	74/7206	8.5237931154e-06
ko04621	NOD-like receptor signaling pathway	9/1262	157/7206	1.68378480685e-05
ko05164	Influenza A	10/1262	167/7206	1.81828065494e-05
ko04745	Phototransduction - fly	18/1262	38/7206	2.06675162885e-05
ko04120	Ubiquitin mediated proteolysis	7/1262	138/7206	2.07930944102e-05
ko04972	Pancreatic secretion	38/1262	111/7206	2.13377640546e-05
ko05169	Epstein-Barr virus infection	15/1262	206/7206	2.40564522661e-05
ko04070	Phosphatidylinositol signaling system	38/1262	112/7206	2.4151817475e-05
ko04966	Collecting duct acid secretion	14/1262	26/7206	2.81621078147e-05
ko04260	Cardiac muscle contraction	34/1262	98/7206	3.94156229269e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1262	79/7206	7.05822184387e-05
ko05110	Vibrio cholerae infection	24/1262	63/7206	8.62012320902e-05
ko04110	Cell cycle	9/1262	145/7206	9.18493607088e-05
ko04612	Antigen processing and presentation	2/1262	77/7206	0.000107764449627
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1262	79/7206	0.000132042169171
ko04514	Cell adhesion molecules (CAMs)	40/1262	130/7206	0.000169559391177
ko04371	Apelin signaling pathway	51/1262	177/7206	0.00018149675399
ko04014	Ras signaling pathway	73/1262	279/7206	0.00020737814487
ko05162	Measles	7/1262	120/7206	0.000235653714609
ko04072	Phospholipase D signaling pathway	55/1262	197/7206	0.000267595422745
ko05414	Dilated cardiomyopathy	35/1262	112/7206	0.00036709948576
ko04750	Inflammatory mediator regulation of TRP channels	37/1262	122/7206	0.000432401996768
ko04915	Estrogen signaling pathway	39/1262	131/7206	0.000452031651519
ko04976	Bile secretion	27/1262	80/7206	0.000502737648933
ko00520	Amino sugar and nucleotide sugar metabolism	1/1262	55/7206	0.000523331640322
ko00480	Glutathione metabolism	1/1262	55/7206	0.000523331640322
ko05205	Proteoglycans in cancer	27/1262	271/7206	0.000580205108116
ko04064	NF-kappa B signaling pathway	5/1262	96/7206	0.000598059464027
ko05140	Leishmaniasis	3/1262	75/7206	0.000655273430065
ko00240	Pyrimidine metabolism	7/1262	110/7206	0.000905269190416
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1262	14/7206	0.00095671450106
ko04626	Plant-pathogen interaction	9/1262	18/7206	0.00160765535901
ko04146	Peroxisome	5/1262	89/7206	0.00172753510257
ko04912	GnRH signaling pathway	35/1262	122/7206	0.00239599726191
ko04657	IL-17 signaling pathway	5/1262	87/7206	0.00248180049431
ko05144	Malaria	1/1262	45/7206	0.00275516348999
ko00071	Fatty acid degradation	1/1262	45/7206	0.00275516348999
ko03420	Nucleotide excision repair	1/1262	46/7206	0.0027935903839
ko03018	RNA degradation	5/1262	84/7206	0.00341849727723
ko04923	Regulation of lipolysis in adipocytes	24/1262	77/7206	0.00360249009061
ko05321	Inflammatory bowel disease (IBD)	2/1262	56/7206	0.0038813033747
ko03022	Basal transcription factors	1/1262	44/7206	0.00428768087526
ko04640	Hematopoietic cell lineage	3/1262	64/7206	0.00431210806542
ko04214	Apoptosis - fly	4/1262	72/7206	0.00457668101533
ko04270	Vascular smooth muscle contraction	41/1262	154/7206	0.00500198393998
ko04916	Melanogenesis	38/1262	142/7206	0.00511465077941
ko00590	Arachidonic acid metabolism	2/1262	52/7206	0.00537692347123
ko05231	Choline metabolism in cancer	36/1262	134/7206	0.00577023401019
ko05161	Hepatitis B	17/1262	173/7206	0.00599989299161
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1262	40/7206	0.00630060001945
ko04622	RIG-I-like receptor signaling pathway	3/1262	62/7206	0.00631200524805
ko05145	Toxoplasmosis	11/1262	126/7206	0.00640304907479
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1262	100/7206	0.00785785588252
ko00630	Glyoxylate and dicarboxylate metabolism	1/1262	38/7206	0.00944849226066
ko03410	Base excision repair	1/1262	38/7206	0.00944849226066
ko05166	HTLV-I infection	35/1262	292/7206	0.00947386510335
ko04922	Glucagon signaling pathway	34/1262	128/7206	0.00947749815995
ko05214	Glioma	23/1262	79/7206	0.0105575033133
ko04964	Proximal tubule bicarbonate reclamation	11/1262	29/7206	0.0109715924417
ko05418	Fluid shear stress and atherosclerosis	18/1262	173/7206	0.0111274018699
ko05131	Shigellosis	6/1262	82/7206	0.0122795649668
ko04015	Rap1 signaling pathway	65/1262	278/7206	0.0123277731807
ko04217	Necroptosis	19/1262	178/7206	0.0125268379025
ko04115	p53 signaling pathway	5/1262	74/7206	0.0128900641688
ko04658	Th1 and Th2 cell differentiation	8/1262	96/7206	0.0145341740841
ko00982	Drug metabolism - cytochrome P450	1/1262	37/7206	0.0147028375538
ko05133	Pertussis	7/1262	87/7206	0.0156726832936
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1262	182/7206	0.0175182915623
ko04350	TGF-beta signaling pathway	9/1262	103/7206	0.0179315157442
ko00860	Porphyrin and chlorophyll metabolism	1/1262	34/7206	0.0215168151229
ko00500	Starch and sucrose metabolism	1/1262	35/7206	0.0225223329355
ko01524	Platinum drug resistance	6/1262	76/7206	0.0227201899736
ko04620	Toll-like receptor signaling pathway	9/1262	100/7206	0.0235326215907
ko00562	Inositol phosphate metabolism	24/1262	89/7206	0.0240315664469
ko00983	Drug metabolism - other enzymes	2/1262	42/7206	0.0244494050504
ko03320	PPAR signaling pathway	5/1262	69/7206	0.0244684623086
ko01200	Carbon metabolism	13/1262	128/7206	0.0254852718958
ko04668	TNF signaling pathway	12/1262	120/7206	0.028683112262
ko04062	Chemokine signaling pathway	47/1262	201/7206	0.0302443935613
ko04918	Thyroid hormone synthesis	23/1262	86/7206	0.0312133163525
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1262	15/7206	0.0341031070115
ko05222	Small cell lung cancer	8/1262	89/7206	0.0343248255624
ko05204	Chemical carcinogenesis	3/1262	48/7206	0.0359797060221
ko00260	Glycine, serine and threonine metabolism	3/1262	48/7206	0.0359797060221
ko00140	Steroid hormone biosynthesis	2/1262	41/7206	0.0364015736739
ko04210	Apoptosis	21/1262	180/7206	0.0367463455489
ko04630	Jak-STAT signaling pathway	14/1262	132/7206	0.0368113283029
ko05034	Alcoholism	54/1262	238/7206	0.0371698861953
ko04973	Carbohydrate digestion and absorption	13/1262	42/7206	0.0382884183187
ko04142	Lysosome	17/1262	151/7206	0.0397812879933
ko04114	Oocyte meiosis	34/1262	139/7206	0.0415694731606
ko00310	Lysine degradation	6/1262	73/7206	0.0423758277963
ko00600	Sphingolipid metabolism	5/1262	63/7206	0.0450286784948
ko04140	Autophagy - animal	19/1262	164/7206	0.0476433922898
ko05320	Autoimmune thyroid disease	1/1262	29/7206	0.0478556593379
ko00280	Valine, leucine and isoleucine degradation	4/1262	54/7206	0.0482770467082
ko05340	Primary immunodeficiency	1/1262	30/7206	0.0495567071458