ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1167	423/7206	8.51032667651e-51
ko04724	Glutamatergic synapse	87/1167	152/7206	1.93363682546e-31
ko05033	Nicotine addiction	48/1167	56/7206	1.85106788214e-30
ko04721	Synaptic vesicle cycle	56/1167	80/7206	5.21893200082e-27
ko05032	Morphine addiction	66/1167	110/7206	1.04725167738e-25
ko04727	GABAergic synapse	64/1167	110/7206	6.48665031712e-24
ko04713	Circadian entrainment	71/1167	136/7206	1.36928077717e-22
ko04725	Cholinergic synapse	74/1167	160/7206	1.76973455611e-19
ko04728	Dopaminergic synapse	81/1167	185/7206	2.21497670714e-19
ko04723	Retrograde endocannabinoid signaling	76/1167	175/7206	5.34562060969e-18
ko04024	cAMP signaling pathway	101/1167	279/7206	1.48787752983e-16
ko04742	Taste transduction	37/1167	61/7206	3.75037352481e-15
ko04020	Calcium signaling pathway	91/1167	265/7206	1.88427390556e-13
ko04911	Insulin secretion	52/1167	117/7206	3.53000486038e-13
ko04921	Oxytocin signaling pathway	76/1167	209/7206	5.82945875584e-13
ko04726	Serotonergic synapse	57/1167	137/7206	7.83778972339e-13
ko04744	Phototransduction	25/1167	36/7206	1.33857697952e-12
ko04720	Long-term potentiation	44/1167	99/7206	2.37632200104e-11
ko05031	Amphetamine addiction	40/1167	91/7206	2.93062357538e-10
ko03040	Spliceosome	1/1167	145/7206	3.17197686327e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1167	205/7206	4.70048641889e-10
ko04970	Salivary secretion	38/1167	95/7206	1.98996118504e-08
ko04360	Axon guidance	71/1167	233/7206	3.34177930965e-08
ko05168	Herpes simplex infection	6/1167	182/7206	3.6394778391e-08
ko05203	Viral carcinogenesis	15/1167	277/7206	4.14065241145e-08
ko04966	Collecting duct acid secretion	16/1167	26/7206	2.13902344397e-07
ko04060	Cytokine-cytokine receptor interaction	8/1167	191/7206	2.50197668492e-07
ko04740	Olfactory transduction	31/1167	80/7206	9.20117897299e-07
ko05030	Cocaine addiction	29/1167	73/7206	1.12663488347e-06
ko03013	RNA transport	7/1167	166/7206	1.89871881603e-06
ko05164	Influenza A	7/1167	167/7206	1.91713934229e-06
ko04260	Cardiac muscle contraction	35/1167	98/7206	2.32027785237e-06
ko04925	Aldosterone synthesis and secretion	36/1167	105/7206	5.58162229362e-06
ko04971	Gastric acid secretion	34/1167	98/7206	5.79072304471e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1167	74/7206	7.27814462512e-06
ko04540	Gap junction	40/1167	128/7206	1.71509241235e-05
ko04120	Ubiquitin mediated proteolysis	6/1167	138/7206	2.06790123012e-05
ko04621	NOD-like receptor signaling pathway	8/1167	157/7206	2.53961600335e-05
ko04745	Phototransduction - fly	17/1167	38/7206	3.09013200644e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1167	79/7206	3.55537956775e-05
ko05110	Vibrio cholerae infection	24/1167	63/7206	3.56519449765e-05
ko04141	Protein processing in endoplasmic reticulum	11/1167	184/7206	4.02209495387e-05
ko04022	cGMP-PKG signaling pathway	58/1167	216/7206	4.85427620609e-05
ko04924	Renin secretion	29/1167	86/7206	5.09119613636e-05
ko04010	MAPK signaling pathway	79/1167	321/7206	7.02605959418e-05
ko05322	Systemic lupus erythematosus	8/1167	151/7206	7.30060768228e-05
ko05162	Measles	5/1167	120/7206	7.8919969467e-05
ko04514	Cell adhesion molecules (CAMs)	39/1167	130/7206	9.12524434264e-05
ko05205	Proteoglycans in cancer	22/1167	271/7206	9.98537773894e-05
ko05414	Dilated cardiomyopathy	34/1167	112/7206	0.000145832364919
ko04730	Long-term depression	26/1167	78/7206	0.000157196114559
ko05169	Epstein-Barr virus infection	15/1167	206/7206	0.000165507600894
ko04610	Complement and coagulation cascades	2/1167	79/7206	0.00017243001153
ko03008	Ribosome biogenesis in eukaryotes	2/1167	79/7206	0.00017243001153
ko04972	Pancreatic secretion	33/1167	111/7206	0.000360230679922
ko05140	Leishmaniasis	2/1167	75/7206	0.000387956661895
ko04064	NF-kappa B signaling pathway	4/1167	96/7206	0.000404678141529
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1167	14/7206	0.00055403162524
ko04626	Plant-pathogen interaction	9/1167	18/7206	0.000897390517326
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1167	59/7206	0.000989863474241
ko04070	Phosphatidylinositol signaling system	32/1167	112/7206	0.00103752987771
ko05161	Hepatitis B	13/1167	173/7206	0.00108837165796
ko04014	Ras signaling pathway	66/1167	279/7206	0.00115320119636
ko04146	Peroxisome	4/1167	89/7206	0.0012118139924
ko04110	Cell cycle	10/1167	145/7206	0.00128439182691
ko00480	Glutathione metabolism	1/1167	55/7206	0.0013388907965
ko04612	Antigen processing and presentation	3/1167	77/7206	0.00153978901626
ko04915	Estrogen signaling pathway	35/1167	131/7206	0.00176472329784
ko00590	Arachidonic acid metabolism	1/1167	52/7206	0.00198386713011
ko03018	RNA degradation	4/1167	84/7206	0.00247923697742
ko04072	Phospholipase D signaling pathway	48/1167	197/7206	0.00306133596203
ko00240	Pyrimidine metabolism	7/1167	110/7206	0.00369173254032
ko04750	Inflammatory mediator regulation of TRP channels	32/1167	122/7206	0.00409818562338
ko03420	Nucleotide excision repair	1/1167	46/7206	0.00445042948444
ko05321	Inflammatory bowel disease (IBD)	2/1167	56/7206	0.00572446609788
ko03022	Basal transcription factors	1/1167	44/7206	0.00668557271501
ko05144	Malaria	1/1167	45/7206	0.00688747142316
ko00071	Fatty acid degradation	1/1167	45/7206	0.00688747142316
ko01524	Platinum drug resistance	4/1167	76/7206	0.00699993113467
ko05166	HTLV-I infection	31/1167	292/7206	0.00729094502088
ko04668	TNF signaling pathway	9/1167	120/7206	0.00811406121959
ko04976	Bile secretion	22/1167	80/7206	0.00900654690439
ko04371	Apelin signaling pathway	42/1167	177/7206	0.00938434820167
ko04214	Apoptosis - fly	4/1167	72/7206	0.00967000092127
ko00310	Lysine degradation	4/1167	73/7206	0.00975913448505
ko05145	Toxoplasmosis	10/1167	126/7206	0.00985991525117
ko05418	Fluid shear stress and atherosclerosis	16/1167	173/7206	0.0117096003996
ko04630	Jak-STAT signaling pathway	11/1167	132/7206	0.0117828214845
ko04923	Regulation of lipolysis in adipocytes	21/1167	77/7206	0.012151442478
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1167	100/7206	0.0129424062656
ko03320	PPAR signaling pathway	4/1167	69/7206	0.0135634607013
ko04622	RIG-I-like receptor signaling pathway	3/1167	62/7206	0.0137905904862
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1167	92/7206	0.0146008843634
ko04350	TGF-beta signaling pathway	8/1167	103/7206	0.0152933264533
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1167	40/7206	0.0154905795734
ko04658	Th1 and Th2 cell differentiation	7/1167	96/7206	0.0167389734577
ko00260	Glycine, serine and threonine metabolism	2/1167	48/7206	0.0176608897392
ko05133	Pertussis	6/1167	87/7206	0.0179554402851
ko00982	Drug metabolism - cytochrome P450	1/1167	37/7206	0.022703072661
ko05131	Shigellosis	6/1167	82/7206	0.0237635249631
ko04140	Autophagy - animal	16/1167	164/7206	0.0237765698011
ko00630	Glyoxylate and dicarboxylate metabolism	1/1167	38/7206	0.0238173880781
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1167	15/7206	0.0238909529707
ko04115	p53 signaling pathway	5/1167	74/7206	0.0253137131763
ko04912	GnRH signaling pathway	29/1167	122/7206	0.0257224206561
ko04640	Hematopoietic cell lineage	4/1167	64/7206	0.0262580293941
ko04620	Toll-like receptor signaling pathway	8/1167	100/7206	0.0274972280129
ko05206	MicroRNAs in cancer	18/1167	177/7206	0.0294120988885
ko00640	Propanoate metabolism	1/1167	34/7206	0.0334288702496
ko04670	Leukocyte transendothelial migration	15/1167	151/7206	0.0336740211122
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1167	135/7206	0.0338817517712
ko00330	Arginine and proline metabolism	4/1167	61/7206	0.0363441070384
ko04330	Notch signaling pathway	4/1167	62/7206	0.0364554810828
ko00600	Sphingolipid metabolism	4/1167	63/7206	0.0371552560287
ko05215	Prostate cancer	10/1167	111/7206	0.0374045203356
ko00280	Valine, leucine and isoleucine degradation	3/1167	54/7206	0.0387089442798
ko04657	IL-17 signaling pathway	7/1167	87/7206	0.0393296905998
ko04210	Apoptosis	19/1167	180/7206	0.0398579682565
ko04964	Proximal tubule bicarbonate reclamation	9/1167	29/7206	0.0406610259037
ko05034	Alcoholism	50/1167	238/7206	0.0484693832752
ko04218	Cellular senescence	19/1167	177/7206	0.0491099888312
ko04136	Autophagy - other	1/1167	31/7206	0.0493909373858
ko04916	Melanogenesis	32/1167	142/7206	0.0494477011789