ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 108/771 423/7206 3.66352170218e-19 ko04724 Glutamatergic synapse 57/771 152/7206 1.14914578848e-18 ko04713 Circadian entrainment 49/771 136/7206 2.18632392205e-15 ko04721 Synaptic vesicle cycle 36/771 80/7206 3.83877656725e-15 ko04727 GABAergic synapse 43/771 110/7206 4.02746505829e-15 ko05033 Nicotine addiction 29/771 56/7206 1.8967547114e-14 ko05032 Morphine addiction 41/771 110/7206 1.20144719323e-13 ko04728 Dopaminergic synapse 56/771 185/7206 1.21057990365e-13 ko04723 Retrograde endocannabinoid signaling 48/771 175/7206 3.38407981185e-10 ko04725 Cholinergic synapse 45/771 160/7206 5.04015463594e-10 ko04911 Insulin secretion 35/771 117/7206 7.6195605498e-09 ko04020 Calcium signaling pathway 59/771 265/7206 2.36857478804e-08 ko05031 Amphetamine addiction 29/771 91/7206 3.1382352944e-08 ko04921 Oxytocin signaling pathway 50/771 209/7206 3.59902096257e-08 ko04970 Salivary secretion 29/771 95/7206 9.10357839784e-08 ko04024 cAMP signaling pathway 59/771 279/7206 1.73782446006e-07 ko04726 Serotonergic synapse 36/771 137/7206 1.87327873385e-07 ko04022 cGMP-PKG signaling pathway 48/771 216/7206 5.37238501584e-07 ko04966 Collecting duct acid secretion 13/771 26/7206 6.01929142476e-07 ko03040 Spliceosome 1/771 145/7206 2.0228631424e-06 ko04261 Adrenergic signaling in cardiomyocytes 44/771 205/7206 5.03095765179e-06 ko04720 Long-term potentiation 26/771 99/7206 9.58001150388e-06 ko03010 Ribosome 1/771 129/7206 1.01817767872e-05 ko04070 Phosphatidylinositol signaling system 28/771 112/7206 1.49667099594e-05 ko05030 Cocaine addiction 21/771 73/7206 1.52655768471e-05 ko05162 Measles 1/771 120/7206 3.4772191995e-05 ko04925 Aldosterone synthesis and secretion 26/771 105/7206 3.59187873984e-05 ko04971 Gastric acid secretion 25/771 98/7206 3.84844567408e-05 ko04742 Taste transduction 18/771 61/7206 4.23380010014e-05 ko04730 Long-term depression 21/771 78/7206 4.57701863864e-05 ko05164 Influenza A 4/771 167/7206 6.94482179405e-05 ko05322 Systemic lupus erythematosus 3/771 151/7206 8.11927032526e-05 ko04745 Phototransduction - fly 13/771 38/7206 9.21808158746e-05 ko04710 Circadian rhythm 14/771 43/7206 9.22242541346e-05 ko03013 RNA transport 4/771 166/7206 0.00010288804415 ko04514 Cell adhesion molecules (CAMs) 29/771 130/7206 0.000134027176971 ko05203 Viral carcinogenesis 12/771 277/7206 0.000149518347866 ko05014 Amyotrophic lateral sclerosis (ALS) 19/771 74/7206 0.000206817732705 ko05110 Vibrio cholerae infection 17/771 63/7206 0.000231950676153 ko04972 Pancreatic secretion 25/771 111/7206 0.000262777065485 ko05168 Herpes simplex infection 6/771 182/7206 0.000360100609566 ko04371 Apelin signaling pathway 33/771 177/7206 0.00124365565055 ko04014 Ras signaling pathway 47/771 279/7206 0.00145671579895 ko04626 Plant-pathogen interaction 7/771 18/7206 0.00172183075702 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/771 92/7206 0.00177937490632 ko05169 Epstein-Barr virus infection 9/771 206/7206 0.00181048865183 ko04964 Proximal tubule bicarbonate reclamation 9/771 29/7206 0.0024323109011 ko05323 Rheumatoid arthritis 19/771 89/7206 0.00280399091679 ko04922 Glucagon signaling pathway 25/771 128/7206 0.00337473591533 ko04744 Phototransduction 10/771 36/7206 0.00353068508069 ko05140 Leishmaniasis 1/771 75/7206 0.00397274689703 ko04060 Cytokine-cytokine receptor interaction 9/771 191/7206 0.00421257686874 ko04924 Renin secretion 18/771 86/7206 0.00441038735532 ko04120 Ubiquitin mediated proteolysis 5/771 138/7206 0.00482377889804 ko04740 Olfactory transduction 17/771 80/7206 0.00527127542463 ko04110 Cell cycle 6/771 145/7206 0.00633128076628 ko04630 Jak-STAT signaling pathway 5/771 132/7206 0.0064021016685 ko04360 Axon guidance 38/771 233/7206 0.00694578370773 ko04657 IL-17 signaling pathway 2/771 87/7206 0.00761213530276 ko00562 Inositol phosphate metabolism 18/771 89/7206 0.00826951245094 ko05166 HTLV-I infection 18/771 292/7206 0.0088006854081 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/771 59/7206 0.0095272145924 ko04960 Aldosterone-regulated sodium reabsorption 10/771 41/7206 0.00953125392015 ko04750 Inflammatory mediator regulation of TRP channels 22/771 122/7206 0.0118382410108 ko04540 Gap junction 23/771 128/7206 0.0130670230567 ko05130 Pathogenic Escherichia coli infection 2/771 77/7206 0.0149327072338 ko04141 Protein processing in endoplasmic reticulum 10/771 184/7206 0.0154904941615 ko04010 MAPK signaling pathway 48/771 321/7206 0.0159168010514 ko04270 Vascular smooth muscle contraction 26/771 154/7206 0.0170457971012 ko05161 Hepatitis B 9/771 173/7206 0.0171527892959 ko04621 NOD-like receptor signaling pathway 8/771 157/7206 0.0183069260838 ko04015 Rap1 signaling pathway 42/771 278/7206 0.0222177171283 ko05222 Small cell lung cancer 3/771 89/7206 0.0230053255886 ko05016 Huntington's disease 13/771 215/7206 0.0244184229062 ko04072 Phospholipase D signaling pathway 31/771 197/7206 0.0258436556173 ko00280 Valine, leucine and isoleucine degradation 1/771 54/7206 0.0265708395968 ko05321 Inflammatory bowel disease (IBD) 1/771 56/7206 0.0271107734174 ko05217 Basal cell carcinoma 2/771 68/7206 0.0302288306436 ko04011 MAPK signaling pathway - yeast 1/771 53/7206 0.0404353271246 ko05200 Pathways in cancer 39/771 492/7206 0.041035496225 ko04711 Circadian rhythm - fly 4/771 13/7206 0.0423068013076 ko04512 ECM-receptor interaction 3/771 79/7206 0.0433331942498 ko01040 Biosynthesis of unsaturated fatty acids 6/771 25/7206 0.0441843956558 ko04260 Cardiac muscle contraction 17/771 98/7206 0.0458380919506 ko04210 Apoptosis 11/771 180/7206 0.0494579718883