ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 78/377 145/7206 3.67525379608e-63 ko03013 RNA transport 62/377 166/7206 6.15886623119e-38 ko03008 Ribosome biogenesis in eukaryotes 34/377 79/7206 1.87732273603e-23 ko04111 Cell cycle - yeast 28/377 90/7206 3.89786394502e-15 ko03030 DNA replication 19/377 38/7206 4.0983994512e-15 ko03015 mRNA surveillance pathway 27/377 93/7206 8.27179364684e-14 ko04110 Cell cycle 30/377 145/7206 4.81356749072e-11 ko00240 Pyrimidine metabolism 25/377 110/7206 2.54195795296e-10 ko04113 Meiosis - yeast 19/377 70/7206 1.56071832584e-09 ko03430 Mismatch repair 11/377 22/7206 2.91790751592e-09 ko03020 RNA polymerase 12/377 29/7206 8.17397658861e-09 ko03018 RNA degradation 17/377 84/7206 1.16355168501e-06 ko03420 Nucleotide excision repair 12/377 46/7206 2.72241693622e-06 ko04015 Rap1 signaling pathway 1/377 278/7206 6.72010470662e-06 ko03460 Fanconi anemia pathway 11/377 51/7206 4.97599769381e-05 ko04010 MAPK signaling pathway 3/377 321/7206 5.12243124685e-05 ko04360 Axon guidance 1/377 233/7206 7.11019086116e-05 ko03410 Base excision repair 9/377 38/7206 0.000112320154771 ko03440 Homologous recombination 9/377 41/7206 0.000209964552197 ko04151 PI3K-Akt signaling pathway 6/377 390/7206 0.000235829458651 ko04024 cAMP signaling pathway 3/377 279/7206 0.000309003795119 ko04014 Ras signaling pathway 3/377 279/7206 0.000309003795119 ko05010 Alzheimer's disease 1/377 202/7206 0.000334860385989 ko04810 Regulation of actin cytoskeleton 3/377 264/7206 0.000627078158392 ko00230 Purine metabolism 22/377 194/7206 0.000783121267309 ko04022 cGMP-PKG signaling pathway 2/377 216/7206 0.00153785933017 ko04723 Retrograde endocannabinoid signaling 1/377 175/7206 0.0015700972371 ko05168 Herpes simplex infection 20/377 182/7206 0.00182522936663 ko05205 Proteoglycans in cancer 4/377 271/7206 0.00199796923874 ko04261 Adrenergic signaling in cardiomyocytes 2/377 205/7206 0.00212541095299 ko04921 Oxytocin signaling pathway 2/377 209/7206 0.00222888896607 ko04140 Autophagy - animal 1/377 164/7206 0.00225741663698 ko04062 Chemokine signaling pathway 2/377 201/7206 0.00317095903186 ko04722 Neurotrophin signaling pathway 1/377 160/7206 0.00335116498134 ko04725 Cholinergic synapse 1/377 160/7206 0.00335116498134 ko04145 Phagosome 1/377 162/7206 0.00344588085638 ko04530 Tight junction 3/377 228/7206 0.00358321930108 ko05152 Tuberculosis 2/377 187/7206 0.00430547386193 ko04670 Leukocyte transendothelial migration 1/377 151/7206 0.00482269075528 ko04724 Glutamatergic synapse 1/377 152/7206 0.00486052581461 ko05160 Hepatitis C 1/377 153/7206 0.0049140373368 ko04916 Melanogenesis 1/377 142/7206 0.00697271066382 ko03022 Basal transcription factors 7/377 44/7206 0.00726294777515 ko04510 Focal adhesion 4/377 240/7206 0.0073799091043 ko04371 Apelin signaling pathway 2/377 177/7206 0.00902971338033 ko05231 Choline metabolism in cancer 1/377 134/7206 0.0101147194151 ko04713 Circadian entrainment 1/377 136/7206 0.0101938148318 ko04726 Serotonergic synapse 1/377 137/7206 0.0102794695659 ko05200 Pathways in cancer 14/377 492/7206 0.0114814017572 ko04139 Mitophagy - yeast 6/377 37/7206 0.011543697553 ko04068 FoxO signaling pathway 2/377 167/7206 0.0124884591735 ko01200 Carbon metabolism 1/377 128/7206 0.0147355176302 ko05169 Epstein-Barr virus infection 19/377 206/7206 0.0157635091842 ko04728 Dopaminergic synapse 3/377 185/7206 0.0186450252952 ko04666 Fc gamma R-mediated phagocytosis 1/377 122/7206 0.021592984184 ko04660 T cell receptor signaling pathway 1/377 124/7206 0.0221554708112 ko04270 Vascular smooth muscle contraction 2/377 154/7206 0.0254966685053 ko04217 Necroptosis 3/377 178/7206 0.0257607421097 ko03060 Protein export 4/377 23/7206 0.0296325109674 ko04972 Pancreatic secretion 1/377 111/7206 0.0305693908539 ko04727 GABAergic synapse 1/377 110/7206 0.030571585304 ko05032 Morphine addiction 1/377 110/7206 0.030571585304 ko04070 Phosphatidylinositol signaling system 1/377 112/7206 0.0306492468996 ko04013 MAPK signaling pathway - fly 1/377 115/7206 0.0313799115986 ko04120 Ubiquitin mediated proteolysis 13/377 138/7206 0.0330137181812 ko05418 Fluid shear stress and atherosclerosis 3/377 173/7206 0.0358911655869 ko04659 Th17 cell differentiation 1/377 106/7206 0.0445870415375 ko05167 Kaposi's sarcoma-associated herpesvirus infection 4/377 191/7206 0.046965688397 ko04630 Jak-STAT signaling pathway 2/377 132/7206 0.0480622051007 ko04712 Circadian rhythm - plant 2/377 7/7206 0.0481299915053 ko04152 AMPK signaling pathway 3/377 161/7206 0.0484523307245 ko04611 Platelet activation 3/377 163/7206 0.0486369333591 ko04550 Signaling pathways regulating pluripotency of stem cells 3/377 165/7206 0.0491304379862