ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1239	423/7206	2.69914573151e-51
ko04724	Glutamatergic synapse	92/1239	152/7206	9.15231354199e-34
ko05032	Morphine addiction	70/1239	110/7206	8.01822160841e-28
ko05033	Nicotine addiction	47/1239	56/7206	8.47072220659e-28
ko04713	Circadian entrainment	79/1239	136/7206	2.13837944053e-27
ko04727	GABAergic synapse	68/1239	110/7206	5.82518959278e-26
ko04725	Cholinergic synapse	80/1239	160/7206	5.51504144352e-22
ko04721	Synaptic vesicle cycle	52/1239	80/7206	1.41135715746e-21
ko04728	Dopaminergic synapse	86/1239	185/7206	7.38633521144e-21
ko04723	Retrograde endocannabinoid signaling	80/1239	175/7206	6.42429364089e-19
ko04024	cAMP signaling pathway	106/1239	279/7206	2.52284866824e-17
ko04020	Calcium signaling pathway	102/1239	265/7206	3.52302843433e-17
ko04911	Insulin secretion	58/1239	117/7206	4.97407787777e-16
ko04726	Serotonergic synapse	63/1239	137/7206	2.7081604212e-15
ko04742	Taste transduction	37/1239	61/7206	2.6911944916e-14
ko04921	Oxytocin signaling pathway	80/1239	209/7206	2.07440096789e-13
ko04744	Phototransduction	25/1239	36/7206	5.35424379067e-12
ko05031	Amphetamine addiction	43/1239	91/7206	2.48940558902e-11
ko04970	Salivary secretion	44/1239	95/7206	3.38551313133e-11
ko03040	Spliceosome	1/1239	145/7206	4.41089804463e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1239	205/7206	4.70781393951e-11
ko04720	Long-term potentiation	44/1239	99/7206	1.83174875303e-10
ko03010	Ribosome	1/1239	129/7206	9.32704837293e-10
ko04925	Aldosterone synthesis and secretion	42/1239	105/7206	2.42963613741e-08
ko04971	Gastric acid secretion	39/1239	98/7206	9.12984842483e-08
ko03013	RNA transport	7/1239	166/7206	3.84509816926e-07
ko05203	Viral carcinogenesis	19/1239	277/7206	5.34536229281e-07
ko05168	Herpes simplex infection	9/1239	182/7206	7.41135719778e-07
ko04022	cGMP-PKG signaling pathway	66/1239	216/7206	8.86738665412e-07
ko05322	Systemic lupus erythematosus	6/1239	151/7206	9.77026072216e-07
ko04740	Olfactory transduction	32/1239	80/7206	1.30690419857e-06
ko04070	Phosphatidylinositol signaling system	40/1239	112/7206	1.80081165092e-06
ko04966	Collecting duct acid secretion	15/1239	26/7206	3.6349572359e-06
ko04360	Axon guidance	68/1239	233/7206	3.67273738544e-06
ko05030	Cocaine addiction	29/1239	73/7206	4.91998662506e-06
ko04972	Pancreatic secretion	39/1239	111/7206	5.10222329394e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1239	74/7206	6.24748924082e-06
ko04072	Phospholipase D signaling pathway	59/1239	197/7206	8.05993307811e-06
ko04540	Gap junction	42/1239	128/7206	1.43471011707e-05
ko04014	Ras signaling pathway	76/1239	279/7206	2.18927023675e-05
ko04621	NOD-like receptor signaling pathway	9/1239	157/7206	2.44651869711e-05
ko04730	Long-term depression	29/1239	78/7206	2.45936892701e-05
ko04514	Cell adhesion molecules (CAMs)	42/1239	130/7206	2.85711535095e-05
ko04060	Cytokine-cytokine receptor interaction	13/1239	191/7206	3.62709255514e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1239	122/7206	5.19716054152e-05
ko05110	Vibrio cholerae infection	24/1239	63/7206	6.63244618756e-05
ko04745	Phototransduction - fly	17/1239	38/7206	6.82741657292e-05
ko05164	Influenza A	11/1239	167/7206	6.89875240729e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1239	79/7206	7.1324482122e-05
ko04010	MAPK signaling pathway	83/1239	321/7206	7.47350861442e-05
ko04120	Ubiquitin mediated proteolysis	8/1239	138/7206	9.10555442473e-05
ko04976	Bile secretion	28/1239	80/7206	0.00012844247757
ko04110	Cell cycle	9/1239	145/7206	0.000131272718326
ko05414	Dilated cardiomyopathy	35/1239	112/7206	0.000213573639277
ko04141	Protein processing in endoplasmic reticulum	14/1239	184/7206	0.000219381037032
ko04924	Renin secretion	29/1239	86/7206	0.000233825987175
ko04923	Regulation of lipolysis in adipocytes	26/1239	77/7206	0.000368111295873
ko04964	Proximal tubule bicarbonate reclamation	13/1239	29/7206	0.000479554603764
ko04915	Estrogen signaling pathway	38/1239	131/7206	0.000645072274321
ko05169	Epstein-Barr virus infection	18/1239	206/7206	0.000681890790974
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1239	59/7206	0.000693212140348
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1239	79/7206	0.000749238973004
ko04064	NF-kappa B signaling pathway	5/1239	96/7206	0.000893047726993
ko05140	Leishmaniasis	3/1239	75/7206	0.000994560356934
ko04626	Plant-pathogen interaction	9/1239	18/7206	0.00140322892243
ko04371	Apelin signaling pathway	47/1239	177/7206	0.0016334389713
ko04710	Circadian rhythm	16/1239	43/7206	0.00163437673109
ko03420	Nucleotide excision repair	1/1239	46/7206	0.00280195496871
ko05205	Proteoglycans in cancer	29/1239	271/7206	0.00304187462627
ko05162	Measles	9/1239	120/7206	0.00314170799496
ko00240	Pyrimidine metabolism	8/1239	110/7206	0.00327597342113
ko04612	Antigen processing and presentation	4/1239	77/7206	0.00337602298632
ko05161	Hepatitis B	16/1239	173/7206	0.00406778650512
ko03022	Basal transcription factors	1/1239	44/7206	0.0042419547154
ko04260	Cardiac muscle contraction	28/1239	98/7206	0.00439865768272
ko00071	Fatty acid degradation	1/1239	45/7206	0.00440657860468
ko00310	Lysine degradation	4/1239	73/7206	0.00464174095421
ko04912	GnRH signaling pathway	33/1239	122/7206	0.00528304165131
ko04622	RIG-I-like receptor signaling pathway	3/1239	62/7206	0.00621390708138
ko04922	Glucagon signaling pathway	34/1239	128/7206	0.00645774176241
ko04270	Vascular smooth muscle contraction	40/1239	154/7206	0.00657482005502
ko04146	Peroxisome	6/1239	89/7206	0.00664722739052
ko04610	Complement and coagulation cascades	5/1239	79/7206	0.00666891814331
ko04015	Rap1 signaling pathway	65/1239	278/7206	0.00729612185614
ko05145	Toxoplasmosis	11/1239	126/7206	0.0085725618276
ko04658	Th1 and Th2 cell differentiation	7/1239	96/7206	0.00892602979595
ko05133	Pertussis	6/1239	87/7206	0.00926545718075
ko03018	RNA degradation	6/1239	84/7206	0.0125398895383
ko04115	p53 signaling pathway	5/1239	74/7206	0.0128571391994
ko04916	Melanogenesis	36/1239	142/7206	0.0130158678282
ko04918	Thyroid hormone synthesis	24/1239	86/7206	0.0135212777562
ko05231	Choline metabolism in cancer	34/1239	134/7206	0.0148930494541
ko04210	Apoptosis	19/1239	180/7206	0.0159885653609
ko05144	Malaria	2/1239	45/7206	0.0170412895657
ko05131	Shigellosis	6/1239	82/7206	0.0173367983569
ko04214	Apoptosis - fly	5/1239	72/7206	0.0177761169989
ko00280	Valine, leucine and isoleucine degradation	3/1239	54/7206	0.0181188116135
ko04960	Aldosterone-regulated sodium reabsorption	13/1239	41/7206	0.0207032715694
ko04657	IL-17 signaling pathway	7/1239	87/7206	0.021395247959
ko04962	Vasopressin-regulated water reabsorption	17/1239	58/7206	0.0215426819975
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1239	14/7206	0.021960662067
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1239	182/7206	0.0221251869093
ko00562	Inositol phosphate metabolism	24/1239	89/7206	0.02244799893
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1239	100/7206	0.0230822602773
ko04973	Carbohydrate digestion and absorption	13/1239	42/7206	0.0238400571644
ko05202	Transcriptional misregulation in cancer	21/1239	188/7206	0.0242800261188
ko00330	Arginine and proline metabolism	4/1239	61/7206	0.0255320791059
ko00590	Arachidonic acid metabolism	3/1239	52/7206	0.0257549658126
ko04630	Jak-STAT signaling pathway	13/1239	132/7206	0.026123010036
ko04330	Notch signaling pathway	4/1239	62/7206	0.0261321589241
ko05166	HTLV-I infection	36/1239	292/7206	0.0262749817515
ko04930	Type II diabetes mellitus	16/1239	54/7206	0.0274407036186
ko04213	Longevity regulating pathway - multiple species	23/1239	86/7206	0.0295734950153
ko04217	Necroptosis	20/1239	178/7206	0.0341748063447
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1239	40/7206	0.0357982992985
ko00140	Steroid hormone biosynthesis	2/1239	41/7206	0.0359821447702
ko05222	Small cell lung cancer	8/1239	89/7206	0.0462617885531
ko05320	Autoimmune thyroid disease	1/1239	29/7206	0.0480354697901
ko00480	Glutathione metabolism	4/1239	55/7206	0.0486932481273
ko05321	Inflammatory bowel disease (IBD)	4/1239	56/7206	0.048939220616