ko pathway ratio_in_study ratio_in_pop p_value ko05032 Morphine addiction 23/285 110/7206 2.95156592788e-11 ko04726 Serotonergic synapse 22/285 137/7206 1.53900499671e-08 ko04724 Glutamatergic synapse 23/285 152/7206 2.29480818821e-08 ko04911 Insulin secretion 20/285 117/7206 2.39078801287e-08 ko04713 Circadian entrainment 21/285 136/7206 6.69461008997e-08 ko04080 Neuroactive ligand-receptor interaction 41/285 423/7206 8.18689480385e-08 ko04024 cAMP signaling pathway 31/285 279/7206 1.40872260462e-07 ko04725 Cholinergic synapse 21/285 160/7206 1.10912470837e-06 ko04727 GABAergic synapse 17/285 110/7206 1.22208370848e-06 ko04921 Oxytocin signaling pathway 24/285 209/7206 2.18823916682e-06 ko04728 Dopaminergic synapse 22/285 185/7206 3.30058169663e-06 ko04020 Calcium signaling pathway 27/285 265/7206 5.10245600437e-06 ko04745 Phototransduction - fly 9/285 38/7206 1.23757078031e-05 ko04723 Retrograde endocannabinoid signaling 20/285 175/7206 1.69752577689e-05 ko04971 Gastric acid secretion 14/285 98/7206 2.7241673252e-05 ko05033 Nicotine addiction 10/285 56/7206 5.66550863176e-05 ko04744 Phototransduction 8/285 36/7206 6.24407644748e-05 ko04710 Circadian rhythm 8/285 43/7206 0.000235172453169 ko04721 Synaptic vesicle cycle 11/285 80/7206 0.000280825770299 ko00680 Methane metabolism 7/285 34/7206 0.000301464388893 ko04970 Salivary secretion 12/285 95/7206 0.000336229705872 ko04966 Collecting duct acid secretion 6/285 26/7206 0.000427898921071 ko04070 Phosphatidylinositol signaling system 13/285 112/7206 0.000444927746243 ko02010 ABC transporters 7/285 39/7206 0.000727609192265 ko04964 Proximal tubule bicarbonate reclamation 6/285 29/7206 0.000798894812076 ko04925 Aldosterone synthesis and secretion 12/285 105/7206 0.000844310721029 ko04960 Aldosterone-regulated sodium reabsorption 7/285 41/7206 0.000993985849191 ko00030 Pentose phosphate pathway 6/285 32/7206 0.00137940530638 ko04261 Adrenergic signaling in cardiomyocytes 18/285 205/7206 0.00143341920677 ko04720 Long-term potentiation 11/285 99/7206 0.0017372128065 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/285 59/7206 0.00207964525702 ko05031 Amphetamine addiction 10/285 91/7206 0.00302209956179 ko04972 Pancreatic secretion 11/285 111/7206 0.00429289703455 ko04978 Mineral absorption 6/285 40/7206 0.00448354531647 ko04626 Plant-pathogen interaction 4/285 18/7206 0.0047240203609 ko05166 HTLV-I infection 3/285 292/7206 0.00511956408411 ko04260 Cardiac muscle contraction 10/285 98/7206 0.00516977648536 ko01230 Biosynthesis of amino acids 9/285 85/7206 0.00615811048321 ko04022 cGMP-PKG signaling pathway 17/285 216/7206 0.00659648939899 ko04918 Thyroid hormone synthesis 9/285 86/7206 0.00664645190055 ko00010 Glycolysis / Gluconeogenesis 8/285 74/7206 0.00849196394986 ko04742 Taste transduction 7/285 61/7206 0.00985366377363 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/285 92/7206 0.0102286718763 ko05110 Vibrio cholerae infection 7/285 63/7206 0.0116901485817 ko04711 Circadian rhythm - fly 3/285 13/7206 0.0130356605152 ko04740 Olfactory transduction 8/285 80/7206 0.0133371796384 ko05224 Breast cancer 1/285 174/7206 0.0156884223899 ko01200 Carbon metabolism 11/285 128/7206 0.0176890071018 ko04540 Gap junction 11/285 128/7206 0.0176890071018 ko05169 Epstein-Barr virus infection 2/285 206/7206 0.0177468530557 ko04014 Ras signaling pathway 19/285 279/7206 0.0180862516488 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/285 15/7206 0.0195630780064 ko00562 Inositol phosphate metabolism 8/285 89/7206 0.0240107012899 ko00051 Fructose and mannose metabolism 5/285 42/7206 0.0240124505984 ko04973 Carbohydrate digestion and absorption 5/285 42/7206 0.0240124505984 ko00230 Purine metabolism 14/285 194/7206 0.0246318510313 ko05030 Cocaine addiction 7/285 73/7206 0.0247015983799 ko05203 Viral carcinogenesis 4/285 277/7206 0.0262316008801 ko04510 Focal adhesion 3/285 240/7206 0.0265760280459 ko04919 Thyroid hormone signaling pathway 11/285 143/7206 0.0288310007476 ko04371 Apelin signaling pathway 13/285 177/7206 0.029014492386 ko04750 Inflammatory mediator regulation of TRP channels 10/285 122/7206 0.0292691625111 ko00190 Oxidative phosphorylation 10/285 127/7206 0.0341994243667 ko04922 Glucagon signaling pathway 10/285 128/7206 0.0353506550453 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/285 1/7206 0.0395503746879 ko04120 Ubiquitin mediated proteolysis 1/285 138/7206 0.045038841181 ko00510 N-Glycan biosynthesis 5/285 50/7206 0.0464471017947