ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1020	423/7206	1.84396387232e-47
ko04724	Glutamatergic synapse	92/1020	152/7206	6.12793034736e-41
ko05033	Nicotine addiction	49/1020	56/7206	7.72838600813e-35
ko05032	Morphine addiction	68/1020	110/7206	3.08879942815e-31
ko04727	GABAergic synapse	66/1020	110/7206	3.11396495594e-29
ko04713	Circadian entrainment	73/1020	136/7206	6.16290086708e-28
ko04728	Dopaminergic synapse	83/1020	185/7206	1.17779660659e-24
ko04725	Cholinergic synapse	73/1020	160/7206	2.49863525271e-22
ko04723	Retrograde endocannabinoid signaling	76/1020	175/7206	1.40044326781e-21
ko04911	Insulin secretion	59/1020	117/7206	5.85333610701e-21
ko04024	cAMP signaling pathway	96/1020	279/7206	2.55324723648e-18
ko04020	Calcium signaling pathway	90/1020	265/7206	1.33712585378e-16
ko04721	Synaptic vesicle cycle	41/1020	80/7206	2.99776438672e-15
ko04742	Taste transduction	35/1020	61/7206	3.37511686554e-15
ko04726	Serotonergic synapse	55/1020	137/7206	3.83755102448e-14
ko04921	Oxytocin signaling pathway	72/1020	209/7206	5.83736041016e-14
ko05031	Amphetamine addiction	42/1020	91/7206	1.47506210713e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1020	205/7206	2.03579183872e-13
ko04720	Long-term potentiation	42/1020	99/7206	4.85314123897e-12
ko04744	Phototransduction	22/1020	36/7206	8.87828128401e-11
ko04970	Salivary secretion	39/1020	95/7206	9.48423415651e-11
ko05030	Cocaine addiction	33/1020	73/7206	1.24457588466e-10
ko04925	Aldosterone synthesis and secretion	41/1020	105/7206	2.02042672956e-10
ko04010	MAPK signaling pathway	85/1020	321/7206	3.26877998244e-09
ko04971	Gastric acid secretion	37/1020	98/7206	4.67074587022e-09
ko03040	Spliceosome	1/1020	145/7206	9.07880832491e-09
ko04972	Pancreatic secretion	39/1020	111/7206	1.896785707e-08
ko04022	cGMP-PKG signaling pathway	59/1020	216/7206	2.65142542918e-07
ko04072	Phospholipase D signaling pathway	54/1020	197/7206	7.31801498611e-07
ko04730	Long-term depression	28/1020	78/7206	1.17379586023e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1020	74/7206	1.25867155738e-06
ko04360	Axon guidance	60/1020	233/7206	2.02780483601e-06
ko05168	Herpes simplex infection	7/1020	182/7206	7.08073288015e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1020	59/7206	8.04267795429e-06
ko05203	Viral carcinogenesis	16/1020	277/7206	9.32315056802e-06
ko03013	RNA transport	6/1020	166/7206	1.29186793491e-05
ko04540	Gap junction	37/1020	128/7206	1.48891494119e-05
ko05322	Systemic lupus erythematosus	5/1020	151/7206	1.50735410092e-05
ko04070	Phosphatidylinositol signaling system	33/1020	112/7206	2.53776718336e-05
ko04260	Cardiac muscle contraction	29/1020	98/7206	6.00725024208e-05
ko04915	Estrogen signaling pathway	36/1020	131/7206	6.24182792365e-05
ko04060	Cytokine-cytokine receptor interaction	10/1020	191/7206	0.000125682782243
ko03008	Ribosome biogenesis in eukaryotes	1/1020	79/7206	0.000129248445893
ko05414	Dilated cardiomyopathy	31/1020	112/7206	0.000166052283495
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1020	79/7206	0.000228041878076
ko04141	Protein processing in endoplasmic reticulum	10/1020	184/7206	0.00023090725036
ko04740	Olfactory transduction	24/1020	80/7206	0.000254272590807
ko04514	Cell adhesion molecules (CAMs)	34/1020	130/7206	0.000298744938559
ko04621	NOD-like receptor signaling pathway	8/1020	157/7206	0.000438180431305
ko03018	RNA degradation	2/1020	84/7206	0.000440120330699
ko04976	Bile secretion	23/1020	80/7206	0.000568581211718
ko04014	Ras signaling pathway	60/1020	279/7206	0.000608254496342
ko04918	Thyroid hormone synthesis	24/1020	86/7206	0.000831978828109
ko04912	GnRH signaling pathway	31/1020	122/7206	0.000896162983143
ko04640	Hematopoietic cell lineage	1/1020	64/7206	0.000986023129226
ko05164	Influenza A	10/1020	167/7206	0.00105843601457
ko04612	Antigen processing and presentation	2/1020	77/7206	0.00142594640577
ko04745	Phototransduction - fly	13/1020	38/7206	0.00147722685566
ko04110	Cell cycle	8/1020	145/7206	0.00155401320142
ko00240	Pyrimidine metabolism	5/1020	110/7206	0.00209913437173
ko04750	Inflammatory mediator regulation of TRP channels	30/1020	122/7206	0.00225828619934
ko04924	Renin secretion	23/1020	86/7206	0.00258521185856
ko05016	Huntington's disease	16/1020	215/7206	0.00277328824149
ko04270	Vascular smooth muscle contraction	35/1020	154/7206	0.00335563251843
ko03320	PPAR signaling pathway	2/1020	69/7206	0.00457186929756
ko04964	Proximal tubule bicarbonate reclamation	10/1020	29/7206	0.00480210095754
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1020	182/7206	0.0048047344163
ko04923	Regulation of lipolysis in adipocytes	20/1020	77/7206	0.00497672626812
ko04960	Aldosterone-regulated sodium reabsorption	13/1020	41/7206	0.00507653565992
ko00515	Mannose type O-glycan biosynthesis	9/1020	25/7206	0.00533684239474
ko04146	Peroxisome	4/1020	89/7206	0.00538219462588
ko04711	Circadian rhythm - fly	6/1020	13/7206	0.00558409543073
ko00513	Various types of N-glycan biosynthesis	13/1020	42/7206	0.00565452999317
ko05205	Proteoglycans in cancer	23/1020	271/7206	0.00566901238765
ko05169	Epstein-Barr virus infection	16/1020	206/7206	0.00596627214298
ko04062	Chemokine signaling pathway	42/1020	201/7206	0.00748129779002
ko04064	NF-kappa B signaling pathway	5/1020	96/7206	0.00762104942114
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1020	14/7206	0.00861702547965
ko04930	Type II diabetes mellitus	15/1020	54/7206	0.00904371507605
ko00330	Arginine and proline metabolism	2/1020	61/7206	0.00911360785178
ko05034	Alcoholism	48/1020	238/7206	0.0103086111013
ko04137	Mitophagy - animal	4/1020	82/7206	0.0105121404712
ko00260	Glycine, serine and threonine metabolism	1/1020	48/7206	0.0110273321555
ko04371	Apelin signaling pathway	37/1020	177/7206	0.0118816093384
ko04217	Necroptosis	14/1020	178/7206	0.0120980650755
ko04142	Lysosome	11/1020	151/7206	0.0127087246862
ko04973	Carbohydrate digestion and absorption	12/1020	42/7206	0.0128858407129
ko04015	Rap1 signaling pathway	54/1020	278/7206	0.0137007764654
ko00071	Fatty acid degradation	1/1020	45/7206	0.0163230274422
ko05162	Measles	8/1020	120/7206	0.0165998771087
ko05110	Vibrio cholerae infection	16/1020	63/7206	0.016694517041
ko05231	Choline metabolism in cancer	29/1020	134/7206	0.0168559712205
ko00620	Pyruvate metabolism	1/1020	46/7206	0.0169211501717
ko03420	Nucleotide excision repair	1/1020	46/7206	0.0169211501717
ko00480	Glutathione metabolism	2/1020	55/7206	0.0189850550785
ko05321	Inflammatory bowel disease (IBD)	2/1020	56/7206	0.0192052003062
ko01200	Carbon metabolism	9/1020	128/7206	0.0203052715442
ko04916	Melanogenesis	30/1020	142/7206	0.0205067663574
ko00510	N-Glycan biosynthesis	13/1020	50/7206	0.0235024490904
ko04670	Leukocyte transendothelial migration	12/1020	151/7206	0.0246788627467
ko04114	Oocyte meiosis	29/1020	139/7206	0.0266926425243
ko00310	Lysine degradation	4/1020	73/7206	0.0279936700596
ko04115	p53 signaling pathway	4/1020	74/7206	0.0281087345086
ko00280	Valine, leucine and isoleucine degradation	2/1020	54/7206	0.0283517845353
ko04071	Sphingolipid signaling pathway	33/1020	162/7206	0.0294590536125
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1020	100/7206	0.0295970047776
ko00562	Inositol phosphate metabolism	20/1020	89/7206	0.0310801467967
ko04120	Ubiquitin mediated proteolysis	11/1020	138/7206	0.0354147600445
ko05418	Fluid shear stress and atherosclerosis	15/1020	173/7206	0.03557947076
ko04214	Apoptosis - fly	4/1020	72/7206	0.0392926312209
ko04210	Apoptosis	16/1020	180/7206	0.0394049346572
ko01212	Fatty acid metabolism	3/1020	60/7206	0.0396699863443
ko04622	RIG-I-like receptor signaling pathway	3/1020	62/7206	0.0412733169641
ko04213	Longevity regulating pathway - multiple species	19/1020	86/7206	0.0419534231671
ko04218	Cellular senescence	16/1020	177/7206	0.0490511005718
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1020	15/7206	0.0496652465463