ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1272	423/7206	3.50466939278e-57
ko04724	Glutamatergic synapse	94/1272	152/7206	1.31177436373e-34
ko05032	Morphine addiction	75/1272	110/7206	5.55667481818e-32
ko05033	Nicotine addiction	50/1272	56/7206	1.05635288977e-31
ko04713	Circadian entrainment	82/1272	136/7206	3.6234977145e-29
ko04727	GABAergic synapse	71/1272	110/7206	4.88861431792e-28
ko04728	Dopaminergic synapse	90/1272	185/7206	1.08491294633e-22
ko04725	Cholinergic synapse	81/1272	160/7206	6.23764398411e-22
ko04721	Synaptic vesicle cycle	52/1272	80/7206	4.89513141446e-21
ko04723	Retrograde endocannabinoid signaling	83/1272	175/7206	4.18756361791e-20
ko04020	Calcium signaling pathway	109/1272	265/7206	7.90118088884e-20
ko04024	cAMP signaling pathway	112/1272	279/7206	1.85508880004e-19
ko04911	Insulin secretion	61/1272	117/7206	1.33102068066e-17
ko04726	Serotonergic synapse	64/1272	137/7206	2.33790177685e-15
ko04742	Taste transduction	37/1272	61/7206	6.348332881e-14
ko04744	Phototransduction	27/1272	36/7206	6.65025315753e-14
ko04921	Oxytocin signaling pathway	82/1272	209/7206	8.54091125565e-14
ko05031	Amphetamine addiction	45/1272	91/7206	2.94040684502e-12
ko04261	Adrenergic signaling in cardiomyocytes	77/1272	205/7206	5.79696622827e-12
ko04720	Long-term potentiation	47/1272	99/7206	6.2551214353e-12
ko04970	Salivary secretion	45/1272	95/7206	1.94996227848e-11
ko03040	Spliceosome	1/1272	145/7206	2.6039237271e-11
ko04740	Olfactory transduction	38/1272	80/7206	6.59068642715e-10
ko04925	Aldosterone synthesis and secretion	44/1272	105/7206	5.44094945375e-09
ko04360	Axon guidance	77/1272	233/7206	7.47332952908e-09
ko04971	Gastric acid secretion	40/1272	98/7206	5.69618345303e-08
ko05030	Cocaine addiction	32/1272	73/7206	1.5911766733e-07
ko05203	Viral carcinogenesis	19/1272	277/7206	1.90545476867e-07
ko04022	cGMP-PKG signaling pathway	69/1272	216/7206	2.49250818982e-07
ko03013	RNA transport	7/1272	166/7206	2.53758485595e-07
ko05322	Systemic lupus erythematosus	6/1272	151/7206	4.2545514326e-07
ko04972	Pancreatic secretion	41/1272	111/7206	1.00462521249e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1272	74/7206	1.37050647854e-06
ko04060	Cytokine-cytokine receptor interaction	11/1272	191/7206	1.69843996362e-06
ko04010	MAPK signaling pathway	90/1272	321/7206	2.80523422917e-06
ko04070	Phosphatidylinositol signaling system	40/1272	112/7206	4.03356607442e-06
ko05164	Influenza A	9/1272	167/7206	4.30680983772e-06
ko05168	Herpes simplex infection	11/1272	182/7206	4.67235653894e-06
ko04540	Gap junction	43/1272	128/7206	1.0639019457e-05
ko04621	NOD-like receptor signaling pathway	9/1272	157/7206	1.70755732198e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1272	122/7206	1.89554428333e-05
ko04966	Collecting duct acid secretion	14/1272	26/7206	3.08973310416e-05
ko04730	Long-term depression	29/1272	78/7206	3.45929336955e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1272	59/7206	3.62599739941e-05
ko04141	Protein processing in endoplasmic reticulum	13/1272	184/7206	4.82284001362e-05
ko04612	Antigen processing and presentation	2/1272	77/7206	6.84111215032e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1272	79/7206	7.22297608911e-05
ko04745	Phototransduction - fly	17/1272	38/7206	9.61820514509e-05
ko04514	Cell adhesion molecules (CAMs)	41/1272	130/7206	0.00010144160571
ko04014	Ras signaling pathway	75/1272	279/7206	0.000108203229846
ko04072	Phospholipase D signaling pathway	56/1272	197/7206	0.000137759763307
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1272	79/7206	0.000142724223579
ko04924	Renin secretion	30/1272	86/7206	0.000150973490531
ko05414	Dilated cardiomyopathy	36/1272	112/7206	0.000153804762378
ko05110	Vibrio cholerae infection	24/1272	63/7206	0.000159406056273
ko05162	Measles	7/1272	120/7206	0.00023734662272
ko04110	Cell cycle	10/1272	145/7206	0.000242913849335
ko04976	Bile secretion	27/1272	80/7206	0.000528963846372
ko04260	Cardiac muscle contraction	31/1272	98/7206	0.000709266058657
ko05169	Epstein-Barr virus infection	19/1272	206/7206	0.000785491564568
ko04146	Peroxisome	5/1272	89/7206	0.00118352197518
ko04923	Regulation of lipolysis in adipocytes	25/1272	77/7206	0.00139511697435
ko04710	Circadian rhythm	16/1272	43/7206	0.00201915921224
ko00240	Pyrimidine metabolism	8/1272	110/7206	0.00233533868182
ko04915	Estrogen signaling pathway	37/1272	131/7206	0.00244138716079
ko04371	Apelin signaling pathway	47/1272	177/7206	0.00263489311601
ko05144	Malaria	1/1272	45/7206	0.00273289927532
ko00071	Fatty acid degradation	1/1272	45/7206	0.00273289927532
ko03420	Nucleotide excision repair	1/1272	46/7206	0.00281650723258
ko05205	Proteoglycans in cancer	30/1272	271/7206	0.00332520078264
ko05131	Shigellosis	5/1272	82/7206	0.00332555039651
ko04711	Circadian rhythm - fly	7/1272	13/7206	0.00334612412729
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1272	182/7206	0.00413779625807
ko04622	RIG-I-like receptor signaling pathway	3/1272	62/7206	0.0042208000002
ko03022	Basal transcription factors	1/1272	44/7206	0.00434384658634
ko04120	Ubiquitin mediated proteolysis	12/1272	138/7206	0.00449566421609
ko04912	GnRH signaling pathway	34/1272	122/7206	0.00543858391766
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1272	14/7206	0.00568177758333
ko00330	Arginine and proline metabolism	3/1272	61/7206	0.00615283425302
ko04658	Th1 and Th2 cell differentiation	7/1272	96/7206	0.00642010759842
ko04064	NF-kappa B signaling pathway	7/1272	96/7206	0.00642010759842
ko04657	IL-17 signaling pathway	6/1272	87/7206	0.0065545676415
ko05133	Pertussis	6/1272	87/7206	0.0065545676415
ko04610	Complement and coagulation cascades	5/1272	79/7206	0.00678501495239
ko00562	Inositol phosphate metabolism	26/1272	89/7206	0.00719945150651
ko04626	Plant-pathogen interaction	8/1272	18/7206	0.00756919305872
ko03018	RNA degradation	6/1272	84/7206	0.00892155819957
ko05140	Leishmaniasis	5/1272	75/7206	0.00910383693755
ko00630	Glyoxylate and dicarboxylate metabolism	1/1272	38/7206	0.0094005488905
ko03410	Base excision repair	1/1272	38/7206	0.0094005488905
ko04918	Thyroid hormone synthesis	25/1272	86/7206	0.0095774950289
ko04964	Proximal tubule bicarbonate reclamation	11/1272	29/7206	0.0112485029111
ko04217	Necroptosis	19/1272	178/7206	0.0124840232822
ko00480	Glutathione metabolism	3/1272	55/7206	0.0124885332388
ko05321	Inflammatory bowel disease (IBD)	3/1272	56/7206	0.0126051789166
ko04214	Apoptosis - fly	5/1272	72/7206	0.0126280361041
ko00310	Lysine degradation	5/1272	73/7206	0.0127058504753
ko04015	Rap1 signaling pathway	65/1272	278/7206	0.012784096271
ko04640	Hematopoietic cell lineage	4/1272	64/7206	0.0128018292275
ko04115	p53 signaling pathway	5/1272	74/7206	0.0130505340597
ko05145	Toxoplasmosis	12/1272	126/7206	0.0131174016682
ko04973	Carbohydrate digestion and absorption	14/1272	42/7206	0.0131674527547
ko04630	Jak-STAT signaling pathway	13/1272	132/7206	0.0152987937398
ko05215	Prostate cancer	10/1272	111/7206	0.0163338058472
ko05016	Huntington's disease	25/1272	215/7206	0.0179403332027
ko04270	Vascular smooth muscle contraction	39/1272	154/7206	0.0181315502402
ko00280	Valine, leucine and isoleucine degradation	3/1272	54/7206	0.0181967452907
ko04916	Melanogenesis	36/1272	142/7206	0.0191967745802
ko05161	Hepatitis B	19/1272	173/7206	0.0198011175077
ko00860	Porphyrin and chlorophyll metabolism	1/1272	34/7206	0.021596524135
ko05231	Choline metabolism in cancer	34/1272	134/7206	0.0219268946311
ko05132	Salmonella infection	9/1272	98/7206	0.0233472773343
ko04620	Toll-like receptor signaling pathway	9/1272	100/7206	0.0237116897578
ko04960	Aldosterone-regulated sodium reabsorption	13/1272	41/7206	0.0237879058122
ko03320	PPAR signaling pathway	5/1272	69/7206	0.0247209933063
ko04930	Type II diabetes mellitus	16/1272	54/7206	0.029716644169
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1272	100/7206	0.0339278956711
ko05166	HTLV-I infection	38/1272	292/7206	0.0341878044605
ko04922	Glucagon signaling pathway	32/1272	128/7206	0.0345763502764
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1272	15/7206	0.0353292133412
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1272	40/7206	0.0355265282934
ko00260	Glycine, serine and threonine metabolism	3/1272	48/7206	0.0358336745152
ko05219	Bladder cancer	3/1272	48/7206	0.0358336745152
ko04071	Sphingolipid signaling pathway	39/1272	162/7206	0.0365713598724
ko04210	Apoptosis	21/1272	180/7206	0.0369439674597
ko04142	Lysosome	17/1272	151/7206	0.0397741742888
ko03015	mRNA surveillance pathway	9/1272	93/7206	0.0401701337475
ko04330	Notch signaling pathway	5/1272	62/7206	0.0448432761617
ko01200	Carbon metabolism	14/1272	128/7206	0.0462456741348
ko01524	Platinum drug resistance	7/1272	76/7206	0.0499619347447