ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1256	423/7206	1.55575349241e-54
ko04724	Glutamatergic synapse	91/1256	152/7206	2.17443663313e-32
ko05033	Nicotine addiction	49/1256	56/7206	1.98875670272e-30
ko05032	Morphine addiction	70/1256	110/7206	1.91194612264e-27
ko04713	Circadian entrainment	79/1256	136/7206	5.53556241269e-27
ko04727	GABAergic synapse	69/1256	110/7206	1.63366232939e-26
ko04728	Dopaminergic synapse	89/1256	185/7206	2.02981503314e-22
ko04721	Synaptic vesicle cycle	52/1256	80/7206	2.69127987466e-21
ko04725	Cholinergic synapse	77/1256	160/7206	1.53105796546e-19
ko04723	Retrograde endocannabinoid signaling	80/1256	175/7206	1.51555420884e-18
ko04020	Calcium signaling pathway	105/1256	265/7206	3.68066881607e-18
ko04024	cAMP signaling pathway	106/1256	279/7206	7.76281831179e-17
ko04911	Insulin secretion	58/1256	117/7206	9.4721570765e-16
ko04726	Serotonergic synapse	63/1256	137/7206	5.30981687008e-15
ko04742	Taste transduction	38/1256	61/7206	5.40454177123e-15
ko04744	Phototransduction	27/1256	36/7206	4.81851017412e-14
ko04921	Oxytocin signaling pathway	78/1256	209/7206	3.2781268664e-12
ko04970	Salivary secretion	45/1256	95/7206	1.24453314445e-11
ko05031	Amphetamine addiction	43/1256	91/7206	3.95642372744e-11
ko03040	Spliceosome	1/1256	145/7206	4.43558442285e-11
ko04720	Long-term potentiation	45/1256	99/7206	7.18139319279e-11
ko04740	Olfactory transduction	39/1256	80/7206	9.87986949551e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1256	205/7206	2.44076652797e-10
ko04925	Aldosterone synthesis and secretion	42/1256	105/7206	3.49199533473e-08
ko05203	Viral carcinogenesis	18/1256	277/7206	1.03502057852e-07
ko04971	Gastric acid secretion	39/1256	98/7206	1.27456115172e-07
ko05168	Herpes simplex infection	8/1256	182/7206	1.50240233e-07
ko04621	NOD-like receptor signaling pathway	6/1256	157/7206	3.14145432745e-07
ko04360	Axon guidance	72/1256	233/7206	3.79545482473e-07
ko03013	RNA transport	7/1256	166/7206	3.87892044397e-07
ko05030	Cocaine addiction	31/1256	73/7206	4.39558223465e-07
ko04022	cGMP-PKG signaling pathway	67/1256	216/7206	6.42289188747e-07
ko05322	Systemic lupus erythematosus	6/1256	151/7206	6.42939716475e-07
ko04514	Cell adhesion molecules (CAMs)	45/1256	130/7206	1.83770327371e-06
ko04060	Cytokine-cytokine receptor interaction	11/1256	191/7206	2.46583422119e-06
ko04972	Pancreatic secretion	40/1256	111/7206	3.01958068672e-06
ko05164	Influenza A	9/1256	167/7206	4.2407745374e-06
ko04966	Collecting duct acid secretion	15/1256	26/7206	4.33786012476e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1256	74/7206	7.84006485088e-06
ko04540	Gap junction	42/1256	128/7206	1.79278845874e-05
ko04141	Protein processing in endoplasmic reticulum	12/1256	184/7206	1.85006456665e-05
ko04120	Ubiquitin mediated proteolysis	7/1256	138/7206	2.06517683377e-05
ko04924	Renin secretion	31/1256	86/7206	3.7332279249e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1256	79/7206	7.01758116722e-05
ko04070	Phosphatidylinositol signaling system	37/1256	112/7206	7.2033018022e-05
ko04745	Phototransduction - fly	17/1256	38/7206	8.1583281749e-05
ko04110	Cell cycle	9/1256	145/7206	9.21350304306e-05
ko04010	MAPK signaling pathway	83/1256	321/7206	0.000112780524428
ko04730	Long-term depression	28/1256	78/7206	0.000113868589775
ko04976	Bile secretion	28/1256	80/7206	0.00014585752136
ko04750	Inflammatory mediator regulation of TRP channels	38/1256	122/7206	0.00016510633487
ko05162	Measles	7/1256	120/7206	0.000237200849672
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1256	79/7206	0.000272889184859
ko05110	Vibrio cholerae infection	23/1256	63/7206	0.000300879879471
ko04014	Ras signaling pathway	72/1256	279/7206	0.000367254984542
ko04146	Peroxisome	4/1256	89/7206	0.000369256152061
ko05169	Epstein-Barr virus infection	18/1256	206/7206	0.000512830366139
ko00520	Amino sugar and nucleotide sugar metabolism	1/1256	55/7206	0.000524903833828
ko04064	NF-kappa B signaling pathway	5/1256	96/7206	0.000595658450329
ko05414	Dilated cardiomyopathy	34/1256	112/7206	0.000634595523524
ko05140	Leishmaniasis	3/1256	75/7206	0.00066086810208
ko04612	Antigen processing and presentation	3/1256	77/7206	0.000689208034002
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1256	59/7206	0.000771584719698
ko04072	Phospholipase D signaling pathway	53/1256	197/7206	0.000788383505506
ko05205	Proteoglycans in cancer	28/1256	271/7206	0.00106810769929
ko04260	Cardiac muscle contraction	30/1256	98/7206	0.00116024922605
ko05161	Hepatitis B	15/1256	173/7206	0.00152674618441
ko04610	Complement and coagulation cascades	4/1256	79/7206	0.00158575208572
ko04630	Jak-STAT signaling pathway	10/1256	132/7206	0.00160741613836
ko04964	Proximal tubule bicarbonate reclamation	12/1256	29/7206	0.00209289344036
ko04371	Apelin signaling pathway	47/1256	177/7206	0.00243268240806
ko00071	Fatty acid degradation	1/1256	45/7206	0.00277572278299
ko03420	Nucleotide excision repair	1/1256	46/7206	0.00278760287697
ko04217	Necroptosis	17/1256	178/7206	0.00360149563017
ko04270	Vascular smooth muscle contraction	41/1256	154/7206	0.00361674293068
ko03022	Basal transcription factors	1/1256	44/7206	0.00426459637874
ko05166	HTLV-I infection	33/1256	292/7206	0.00443464177467
ko00310	Lysine degradation	4/1256	73/7206	0.00465313942677
ko05131	Shigellosis	5/1256	82/7206	0.00482450521421
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1256	14/7206	0.00528128025533
ko00330	Arginine and proline metabolism	3/1256	61/7206	0.00613525585476
ko04923	Regulation of lipolysis in adipocytes	23/1256	77/7206	0.00620843759979
ko04330	Notch signaling pathway	3/1256	62/7206	0.00626468435771
ko04622	RIG-I-like receptor signaling pathway	3/1256	62/7206	0.00626468435771
ko04658	Th1 and Th2 cell differentiation	7/1256	96/7206	0.00630281816103
ko05133	Pertussis	6/1256	87/7206	0.00650411989357
ko04626	Plant-pathogen interaction	8/1256	18/7206	0.00699572018894
ko04710	Circadian rhythm	15/1256	43/7206	0.00707021996066
ko04915	Estrogen signaling pathway	35/1256	131/7206	0.00716598411895
ko00240	Pyrimidine metabolism	9/1256	110/7206	0.00753415691376
ko05145	Toxoplasmosis	11/1256	126/7206	0.00863267391606
ko03018	RNA degradation	6/1256	84/7206	0.00895060376598
ko00630	Glyoxylate and dicarboxylate metabolism	1/1256	38/7206	0.0094936408711
ko03410	Base excision repair	1/1256	38/7206	0.0094936408711
ko05219	Bladder cancer	2/1256	48/7206	0.0117128120998
ko05321	Inflammatory bowel disease (IBD)	3/1256	56/7206	0.0126007455218
ko04115	p53 signaling pathway	5/1256	74/7206	0.01283638201
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1256	100/7206	0.0161253695455
ko05215	Prostate cancer	10/1256	111/7206	0.0161864805169
ko05144	Malaria	2/1256	45/7206	0.016897411043
ko00280	Valine, leucine and isoleucine degradation	3/1256	54/7206	0.0180473434151
ko04916	Melanogenesis	36/1256	142/7206	0.0182733067195
ko05220	Chronic myeloid leukemia	7/1256	85/7206	0.0211574038266
ko04657	IL-17 signaling pathway	7/1256	87/7206	0.0216918490545
ko04210	Apoptosis	20/1256	180/7206	0.0219432680487
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1256	182/7206	0.0222632361776
ko00500	Starch and sucrose metabolism	1/1256	35/7206	0.022364287887
ko04620	Toll-like receptor signaling pathway	9/1256	100/7206	0.0235146110978
ko00562	Inositol phosphate metabolism	24/1256	89/7206	0.0235346377506
ko04930	Type II diabetes mellitus	16/1256	54/7206	0.0284594816731
ko04912	GnRH signaling pathway	31/1256	122/7206	0.029293236551
ko04918	Thyroid hormone synthesis	23/1256	86/7206	0.0306881765162
ko05132	Salmonella infection	9/1256	98/7206	0.0310442690099
ko04922	Glucagon signaling pathway	32/1256	128/7206	0.0333607469091
ko04015	Rap1 signaling pathway	62/1256	278/7206	0.0356460858381
ko05016	Huntington's disease	26/1256	215/7206	0.0356814144272
ko00380	Tryptophan metabolism	3/1256	50/7206	0.0370875705172
ko04973	Carbohydrate digestion and absorption	13/1256	42/7206	0.0379276028543
ko04214	Apoptosis - fly	6/1256	72/7206	0.0415488745314
ko05418	Fluid shear stress and atherosclerosis	20/1256	173/7206	0.0419362184097
ko04140	Autophagy - animal	19/1256	164/7206	0.0475530318563