ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1067	423/7206	1.59777026914e-51
ko04724	Glutamatergic synapse	89/1067	152/7206	2.28962433041e-36
ko05033	Nicotine addiction	49/1067	56/7206	7.02832127766e-34
ko04727	GABAergic synapse	67/1067	110/7206	5.17480750435e-29
ko05032	Morphine addiction	66/1067	110/7206	4.82070762646e-28
ko04713	Circadian entrainment	74/1067	136/7206	1.60486301297e-27
ko04728	Dopaminergic synapse	86/1067	185/7206	1.90541895105e-25
ko04725	Cholinergic synapse	75/1067	160/7206	1.40545503098e-22
ko04723	Retrograde endocannabinoid signaling	77/1067	175/7206	4.85712999592e-21
ko04721	Synaptic vesicle cycle	47/1067	80/7206	9.51908586679e-20
ko04024	cAMP signaling pathway	100/1067	279/7206	4.55586400348e-19
ko04020	Calcium signaling pathway	94/1067	265/7206	1.9707612183e-17
ko04911	Insulin secretion	55/1067	117/7206	6.42402868413e-17
ko04921	Oxytocin signaling pathway	76/1067	209/7206	5.71283525111e-15
ko04726	Serotonergic synapse	57/1067	137/7206	1.50703598461e-14
ko04742	Taste transduction	34/1067	61/7206	1.07212608914e-13
ko05031	Amphetamine addiction	43/1067	91/7206	1.34233791246e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1067	205/7206	1.7270887708e-13
ko04720	Long-term potentiation	44/1067	99/7206	1.0263696356e-12
ko04744	Phototransduction	23/1067	36/7206	2.2396278593e-11
ko04970	Salivary secretion	40/1067	95/7206	8.77367845615e-11
ko05030	Cocaine addiction	32/1067	73/7206	2.0203221305e-09
ko04925	Aldosterone synthesis and secretion	40/1067	105/7206	3.13231215743e-09
ko03040	Spliceosome	1/1067	145/7206	3.63365316494e-09
ko05203	Viral carcinogenesis	11/1067	277/7206	4.31082372363e-09
ko04971	Gastric acid secretion	38/1067	98/7206	4.35670773559e-09
ko04010	MAPK signaling pathway	84/1067	321/7206	5.11546828557e-08
ko04360	Axon guidance	66/1067	233/7206	8.72071948007e-08
ko04060	Cytokine-cytokine receptor interaction	6/1067	191/7206	1.39027719694e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1067	74/7206	2.28491245472e-07
ko04972	Pancreatic secretion	38/1067	111/7206	2.30402121864e-07
ko05168	Herpes simplex infection	6/1067	182/7206	4.27339124646e-07
ko04022	cGMP-PKG signaling pathway	59/1067	216/7206	1.3062193365e-06
ko05322	Systemic lupus erythematosus	5/1067	151/7206	6.99622218434e-06
ko04740	Olfactory transduction	28/1067	80/7206	7.68788183427e-06
ko04730	Long-term depression	27/1067	78/7206	1.31088342185e-05
ko04540	Gap junction	38/1067	128/7206	1.31432027364e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1067	79/7206	1.55661751911e-05
ko04072	Phospholipase D signaling pathway	52/1067	197/7206	1.58334798024e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1067	59/7206	1.68008414285e-05
ko03013	RNA transport	7/1067	166/7206	1.93181711964e-05
ko04070	Phosphatidylinositol signaling system	34/1067	112/7206	2.17004283747e-05
ko05414	Dilated cardiomyopathy	33/1067	112/7206	6.8785834075e-05
ko04141	Protein processing in endoplasmic reticulum	10/1067	184/7206	8.41985365638e-05
ko04612	Antigen processing and presentation	1/1067	77/7206	0.00012900285636
ko04120	Ubiquitin mediated proteolysis	6/1067	138/7206	0.00013902799978
ko04514	Cell adhesion molecules (CAMs)	36/1067	130/7206	0.000140736939465
ko04260	Cardiac muscle contraction	29/1067	98/7206	0.000148239962319
ko04621	NOD-like receptor signaling pathway	8/1067	157/7206	0.000154544168791
ko05164	Influenza A	9/1067	167/7206	0.000158474392127
ko04745	Phototransduction - fly	15/1067	38/7206	0.000176422034365
ko04014	Ras signaling pathway	63/1067	279/7206	0.000396013645479
ko04915	Estrogen signaling pathway	35/1067	131/7206	0.000413577878008
ko04750	Inflammatory mediator regulation of TRP channels	33/1067	122/7206	0.00041968922202
ko05169	Epstein-Barr virus infection	14/1067	206/7206	0.00046217222217
ko05110	Vibrio cholerae infection	20/1067	63/7206	0.000544559627111
ko03008	Ribosome biogenesis in eukaryotes	2/1067	79/7206	0.000629924548487
ko05205	Proteoglycans in cancer	22/1067	271/7206	0.000894405063957
ko00240	Pyrimidine metabolism	5/1067	110/7206	0.00100438927628
ko04976	Bile secretion	23/1067	80/7206	0.00123743902051
ko04371	Apelin signaling pathway	42/1067	177/7206	0.00171368325768
ko04924	Renin secretion	24/1067	86/7206	0.00183538003138
ko04912	GnRH signaling pathway	31/1067	122/7206	0.00184246837547
ko04110	Cell cycle	9/1067	145/7206	0.00194663560836
ko04350	TGF-beta signaling pathway	5/1067	103/7206	0.00197375699221
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1067	14/7206	0.00202009770831
ko05321	Inflammatory bowel disease (IBD)	1/1067	56/7206	0.00212662454635
ko04966	Collecting duct acid secretion	10/1067	26/7206	0.00268371296283
ko04015	Rap1 signaling pathway	59/1067	278/7206	0.00328964297666
ko00480	Glutathione metabolism	1/1067	55/7206	0.00333900799021
ko04918	Thyroid hormone synthesis	23/1067	86/7206	0.00338281368471
ko04146	Peroxisome	4/1067	89/7206	0.00378339175194
ko04640	Hematopoietic cell lineage	2/1067	64/7206	0.0041918470791
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1067	182/7206	0.00421810579602
ko05140	Leishmaniasis	3/1067	75/7206	0.00487207569274
ko00590	Arachidonic acid metabolism	1/1067	52/7206	0.00493063459005
ko03018	RNA degradation	4/1067	84/7206	0.00521921825882
ko04064	NF-kappa B signaling pathway	5/1067	96/7206	0.00541862212948
ko00330	Arginine and proline metabolism	2/1067	61/7206	0.00610366997625
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1067	100/7206	0.00657554685476
ko04964	Proximal tubule bicarbonate reclamation	10/1067	29/7206	0.00665652962009
ko04214	Apoptosis - fly	3/1067	72/7206	0.00693985304017
ko00260	Glycine, serine and threonine metabolism	1/1067	48/7206	0.00711370253461
ko04973	Carbohydrate digestion and absorption	13/1067	42/7206	0.00715324691644
ko04270	Vascular smooth muscle contraction	35/1067	154/7206	0.00796097715268
ko04916	Melanogenesis	33/1067	142/7206	0.00809950149285
ko04923	Regulation of lipolysis in adipocytes	20/1067	77/7206	0.00917602551559
ko04140	Autophagy - animal	13/1067	164/7206	0.0101829326369
ko05144	Malaria	1/1067	45/7206	0.0105862264432
ko00071	Fatty acid degradation	1/1067	45/7206	0.0105862264432
ko00620	Pyruvate metabolism	1/1067	46/7206	0.0107715200313
ko03420	Nucleotide excision repair	1/1067	46/7206	0.0107715200313
ko04217	Necroptosis	15/1067	178/7206	0.0136121577163
ko00983	Drug metabolism - other enzymes	1/1067	42/7206	0.015745582224
ko03022	Basal transcription factors	1/1067	44/7206	0.0165352819792
ko05162	Measles	9/1067	120/7206	0.0194803381308
ko00310	Lysine degradation	4/1067	73/7206	0.019832618125
ko04115	p53 signaling pathway	4/1067	74/7206	0.0200097091752
ko05161	Hepatitis B	15/1067	173/7206	0.0222079409943
ko01200	Carbon metabolism	10/1067	128/7206	0.0231907472072
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1067	40/7206	0.0235359474643
ko00562	Inositol phosphate metabolism	21/1067	89/7206	0.0239414693243
ko00140	Steroid hormone biosynthesis	1/1067	41/7206	0.0242829933976
ko04062	Chemokine signaling pathway	41/1067	201/7206	0.0267392505062
ko05131	Shigellosis	5/1067	82/7206	0.0269535027383
ko04137	Mitophagy - animal	5/1067	82/7206	0.0269535027383
ko04622	RIG-I-like receptor signaling pathway	3/1067	62/7206	0.0288150201138
ko04114	Oocyte meiosis	30/1067	139/7206	0.0293062851593
ko05145	Toxoplasmosis	10/1067	126/7206	0.0304170461515
ko04930	Type II diabetes mellitus	14/1067	54/7206	0.031822061348
ko05016	Huntington's disease	21/1067	215/7206	0.0320953213303
ko05034	Alcoholism	47/1067	238/7206	0.0327115560698
ko04657	IL-17 signaling pathway	6/1067	87/7206	0.0333303911074
ko05133	Pertussis	6/1067	87/7206	0.0333303911074
ko00982	Drug metabolism - cytochrome P450	1/1067	37/7206	0.034757088861
ko04630	Jak-STAT signaling pathway	11/1067	132/7206	0.0348122863308
ko00630	Glyoxylate and dicarboxylate metabolism	1/1067	38/7206	0.0356524166747
ko03320	PPAR signaling pathway	4/1067	69/7206	0.038749763189
ko05219	Bladder cancer	2/1067	48/7206	0.0388907612011
ko04626	Plant-pathogen interaction	6/1067	18/7206	0.0394187015347
ko04722	Neurotrophin signaling pathway	33/1067	160/7206	0.0422732101972
ko04210	Apoptosis	17/1067	180/7206	0.0428034668242
ko04960	Aldosterone-regulated sodium reabsorption	11/1067	41/7206	0.0434748153323
ko05231	Choline metabolism in cancer	28/1067	134/7206	0.0495500449843