ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 53/466 191/7206 9.67868184863e-21 ko04380 Osteoclast differentiation 36/466 134/7206 6.38433014686e-14 ko04621 NOD-like receptor signaling pathway 39/466 157/7206 9.0442137878e-14 ko05164 Influenza A 39/466 167/7206 7.68963556889e-13 ko05340 Primary immunodeficiency 16/466 30/7206 4.55968405218e-12 ko04650 Natural killer cell mediated cytotoxicity 28/466 97/7206 6.38999648052e-12 ko05321 Inflammatory bowel disease (IBD) 21/466 56/7206 1.10062587218e-11 ko05162 Measles 31/466 120/7206 1.15472104461e-11 ko05140 Leishmaniasis 24/466 75/7206 1.87576806578e-11 ko05330 Allograft rejection 14/466 24/7206 1.99401634093e-11 ko05152 Tuberculosis 39/466 187/7206 3.29278057764e-11 ko05145 Toxoplasmosis 30/466 126/7206 2.25922619865e-10 ko05320 Autoimmune thyroid disease 14/466 29/7206 5.8320770516e-10 ko04064 NF-kappa B signaling pathway 25/466 96/7206 9.95551935633e-10 ko04612 Antigen processing and presentation 22/466 77/7206 1.52173640521e-09 ko05332 Graft-versus-host disease 11/466 18/7206 1.55118451052e-09 ko05150 Staphylococcus aureus infection 15/466 36/7206 1.82631240373e-09 ko04217 Necroptosis 35/466 178/7206 1.88485373476e-09 ko04620 Toll-like receptor signaling pathway 25/466 100/7206 2.51674510339e-09 ko04659 Th17 cell differentiation 25/466 106/7206 9.17620687086e-09 ko04640 Hematopoietic cell lineage 19/466 64/7206 1.00757579481e-08 ko05168 Herpes simplex infection 34/466 182/7206 1.28014749141e-08 ko04672 Intestinal immune network for IgA production 14/466 37/7206 2.83581991102e-08 ko04630 Jak-STAT signaling pathway 27/466 132/7206 5.97783819707e-08 ko04658 Th1 and Th2 cell differentiation 22/466 96/7206 1.25434356074e-07 ko04660 T cell receptor signaling pathway 25/466 124/7206 2.49985892402e-07 ko05310 Asthma 9/466 17/7206 2.79470921073e-07 ko00120 Primary bile acid biosynthesis 9/466 20/7206 1.6197581251e-06 ko04940 Type I diabetes mellitus 11/466 32/7206 2.73627658403e-06 ko04610 Complement and coagulation cascades 17/466 79/7206 8.55079507103e-06 ko05323 Rheumatoid arthritis 18/466 89/7206 1.16723566671e-05 ko04062 Chemokine signaling pathway 30/466 201/7206 1.36525789972e-05 ko05144 Malaria 12/466 45/7206 1.87388695905e-05 ko05133 Pertussis 17/466 87/7206 3.2661969457e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/466 191/7206 3.63957112166e-05 ko04662 B cell receptor signaling pathway 17/466 88/7206 3.81139000234e-05 ko04145 Phagosome 25/466 162/7206 5.49724747163e-05 ko04622 RIG-I-like receptor signaling pathway 13/466 62/7206 0.000130287026673 ko04310 Wnt signaling pathway 1/466 181/7206 0.000157389717171 ko04137 Mitophagy - animal 15/466 82/7206 0.000205429907095 ko04623 Cytosolic DNA-sensing pathway 10/466 41/7206 0.000210643905052 ko05142 Chagas disease (American trypanosomiasis) 20/466 130/7206 0.000232468327984 ko04723 Retrograde endocannabinoid signaling 1/466 175/7206 0.000232591437075 ko00590 Arachidonic acid metabolism 11/466 52/7206 0.000393387881088 ko05161 Hepatitis B 24/466 173/7206 0.000400304607277 ko04210 Apoptosis 24/466 180/7206 0.000598482418319 ko04728 Dopaminergic synapse 2/466 185/7206 0.000690418563489 ko05034 Alcoholism 4/466 238/7206 0.000707245979211 ko04390 Hippo signaling pathway 2/466 188/7206 0.000725682831773 ko03040 Spliceosome 1/466 145/7206 0.00100966138864 ko04664 Fc epsilon RI signaling pathway 13/466 77/7206 0.00118361615808 ko04916 Melanogenesis 1/466 142/7206 0.00150895177641 ko05146 Amoebiasis 15/466 99/7206 0.00160918338931 ko04611 Platelet activation 21/466 163/7206 0.00200296861634 ko03050 Proteasome 10/466 54/7206 0.00210852026785 ko03010 Ribosome 1/466 129/7206 0.00319769132224 ko04360 Axon guidance 5/466 233/7206 0.00399146101039 ko05206 MicroRNAs in cancer 3/466 177/7206 0.00483371846985 ko05132 Salmonella infection 14/466 98/7206 0.00532986139621 ko04514 Cell adhesion molecules (CAMs) 17/466 130/7206 0.00565079868303 ko04110 Cell cycle 2/466 145/7206 0.00592699652729 ko00592 alpha-Linolenic acid metabolism 5/466 19/7206 0.00603072471862 ko04142 Lysosome 19/466 151/7206 0.00633589290016 ko05160 Hepatitis C 19/466 153/7206 0.00666923671953 ko04911 Insulin secretion 1/466 117/7206 0.00682395357697 ko04146 Peroxisome 13/466 89/7206 0.00697166722625 ko04668 TNF signaling pathway 16/466 120/7206 0.00722479181853 ko00480 Glutathione metabolism 9/466 55/7206 0.00809583006366 ko05416 Viral myocarditis 9/466 55/7206 0.00809583006366 ko04713 Circadian entrainment 2/466 136/7206 0.0122391554394 ko00980 Metabolism of xenobiotics by cytochrome P450 7/466 40/7206 0.0130861980524 ko04530 Tight junction 6/466 228/7206 0.0130948879754 ko04925 Aldosterone synthesis and secretion 1/466 105/7206 0.0144806181779 ko04020 Calcium signaling pathway 8/466 265/7206 0.0154064270795 ko04540 Gap junction 2/466 128/7206 0.0170314185051 ko04144 Endocytosis 33/466 342/7206 0.0178550851549 ko04724 Glutamatergic synapse 3/466 152/7206 0.0183249875916 ko05224 Breast cancer 4/466 174/7206 0.0184964268466 ko04080 Neuroactive ligand-receptor interaction 16/466 423/7206 0.0187147385493 ko04971 Gastric acid secretion 1/466 98/7206 0.020795057615 ko04912 GnRH signaling pathway 2/466 122/7206 0.0240858274205 ko00982 Drug metabolism - cytochrome P450 6/466 37/7206 0.0297529433119 ko01524 Platinum drug resistance 10/466 76/7206 0.029755163529 ko04391 Hippo signaling pathway - fly 1/466 90/7206 0.0297625288358 ko05204 Chemical carcinogenesis 7/466 48/7206 0.0332278441901 ko04726 Serotonergic synapse 3/466 137/7206 0.0346229226316 ko04114 Oocyte meiosis 3/466 139/7206 0.0348707792407 ko04550 Signaling pathways regulating pluripotency of stem cells 4/466 165/7206 0.0351187412167 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/466 5/7206 0.0366144172402 ko04666 Fc gamma R-mediated phagocytosis 14/466 122/7206 0.0376822540825 ko05418 Fluid shear stress and atherosclerosis 18/466 173/7206 0.0408166342541 ko05010 Alzheimer's disease 6/466 202/7206 0.0408357721603 ko05131 Shigellosis 10/466 82/7206 0.0417981775142 ko03320 PPAR signaling pathway 9/466 69/7206 0.0423165251104 ko03018 RNA degradation 1/466 84/7206 0.0429911874154 ko04670 Leukocyte transendothelial migration 16/466 151/7206 0.044058747856 ko04270 Vascular smooth muscle contraction 4/466 154/7206 0.0460505061225 ko04012 ErbB signaling pathway 2/466 109/7206 0.0473666987727 ko05032 Morphine addiction 2/466 110/7206 0.047752307608 ko05016 Huntington's disease 7/466 215/7206 0.0487659233047