ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	150/711	423/7206	3.61278887317e-50
ko04724	Glutamatergic synapse	79/711	152/7206	2.33241901935e-40
ko05033	Nicotine addiction	47/711	56/7206	4.20241499362e-39
ko04727	GABAergic synapse	54/711	110/7206	3.59072769082e-26
ko05032	Morphine addiction	54/711	110/7206	3.59072769082e-26
ko04728	Dopaminergic synapse	71/711	185/7206	6.74254297498e-26
ko04723	Retrograde endocannabinoid signaling	66/711	175/7206	1.28228812029e-23
ko04713	Circadian entrainment	57/711	136/7206	3.31582749067e-23
ko04024	cAMP signaling pathway	80/711	279/7206	1.08498042926e-19
ko04725	Cholinergic synapse	55/711	160/7206	1.1081303193e-17
ko04726	Serotonergic synapse	50/711	137/7206	2.03184069912e-17
ko04911	Insulin secretion	43/711	117/7206	2.87693319595e-15
ko04921	Oxytocin signaling pathway	59/711	209/7206	2.06531511276e-14
ko04020	Calcium signaling pathway	68/711	265/7206	3.50905687681e-14
ko05031	Amphetamine addiction	36/711	91/7206	3.94011874108e-14
ko04720	Long-term potentiation	37/711	99/7206	1.42646754971e-13
ko05030	Cocaine addiction	31/711	73/7206	2.45076745009e-13
ko04261	Adrenergic signaling in cardiomyocytes	55/711	205/7206	1.63471794182e-12
ko04721	Synaptic vesicle cycle	31/711	80/7206	4.61565098927e-12
ko04742	Taste transduction	25/711	61/7206	1.33607547335e-10
ko04970	Salivary secretion	30/711	95/7206	3.43242388061e-09
ko04010	MAPK signaling pathway	65/711	321/7206	8.75464684315e-09
ko05014	Amyotrophic lateral sclerosis (ALS)	25/711	74/7206	1.52530170302e-08
ko04730	Long-term depression	25/711	78/7206	5.05888863667e-08
ko04971	Gastric acid secretion	28/711	98/7206	1.28479633054e-07
ko04972	Pancreatic secretion	30/711	111/7206	1.78461125213e-07
ko04072	Phospholipase D signaling pathway	43/711	197/7206	3.72272810377e-07
ko05203	Viral carcinogenesis	6/711	277/7206	5.13915287218e-07
ko04925	Aldosterone synthesis and secretion	28/711	105/7206	6.20174896696e-07
ko04060	Cytokine-cytokine receptor interaction	2/711	191/7206	8.49362372445e-07
ko04022	cGMP-PKG signaling pathway	43/711	216/7206	6.83278657074e-06
ko05168	Herpes simplex infection	3/711	182/7206	1.3048421723e-05
ko04915	Estrogen signaling pathway	29/711	131/7206	2.27901891128e-05
ko04070	Phosphatidylinositol signaling system	26/711	112/7206	3.20363370233e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/711	79/7206	5.63605040797e-05
ko04740	Olfactory transduction	20/711	80/7206	6.83354552991e-05
ko04514	Cell adhesion molecules (CAMs)	28/711	130/7206	6.93643148615e-05
ko05034	Alcoholism	43/711	238/7206	8.60855554535e-05
ko04260	Cardiac muscle contraction	23/711	98/7206	9.36771821029e-05
ko04540	Gap junction	27/711	128/7206	0.000123125879974
ko05169	Epstein-Barr virus infection	6/711	206/7206	0.000195116840293
ko04924	Renin secretion	20/711	86/7206	0.000324741845612
ko05414	Dilated cardiomyopathy	23/711	112/7206	0.000592993932278
ko05231	Choline metabolism in cancer	26/711	134/7206	0.000639889603338
ko05164	Influenza A	5/711	167/7206	0.000942298759887
ko05322	Systemic lupus erythematosus	4/711	151/7206	0.00126062187997
ko04964	Proximal tubule bicarbonate reclamation	9/711	29/7206	0.00137311820551
ko04015	Rap1 signaling pathway	44/711	278/7206	0.00137575434841
ko04014	Ras signaling pathway	44/711	279/7206	0.00142710509573
ko04110	Cell cycle	4/711	145/7206	0.00170884448741
ko04621	NOD-like receptor signaling pathway	5/711	157/7206	0.0025672932345
ko03018	RNA degradation	1/711	84/7206	0.00274430146909
ko04745	Phototransduction - fly	10/711	38/7206	0.00299571592979
ko04371	Apelin signaling pathway	30/711	177/7206	0.00300233347982
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/711	182/7206	0.0035063076113
ko04141	Protein processing in endoplasmic reticulum	7/711	184/7206	0.00358993415855
ko04350	TGF-beta signaling pathway	2/711	103/7206	0.00386961246977
ko04610	Complement and coagulation cascades	1/711	79/7206	0.00403494616406
ko04750	Inflammatory mediator regulation of TRP channels	22/711	122/7206	0.00512041103186
ko04612	Antigen processing and presentation	1/711	77/7206	0.00603425065957
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/711	59/7206	0.00632350782397
ko04973	Carbohydrate digestion and absorption	10/711	42/7206	0.00649946220241
ko04071	Sphingolipid signaling pathway	27/711	162/7206	0.0070053134579
ko00515	Mannose type O-glycan biosynthesis	7/711	25/7206	0.00870087479188
ko00240	Pyrimidine metabolism	3/711	110/7206	0.00879894308484
ko04120	Ubiquitin mediated proteolysis	5/711	138/7206	0.00899257123839
ko04360	Axon guidance	35/711	233/7206	0.0100482216249
ko05410	Hypertrophic cardiomyopathy (HCM)	18/711	100/7206	0.0104252045834
ko04217	Necroptosis	8/711	178/7206	0.0107641948788
ko03013	RNA transport	7/711	166/7206	0.0115810026248
ko04142	Lysosome	6/711	151/7206	0.0121525888071
ko05162	Measles	4/711	120/7206	0.0124585317825
ko04976	Bile secretion	15/711	80/7206	0.0128999329621
ko04912	GnRH signaling pathway	21/711	122/7206	0.0129745910603
ko04012	ErbB signaling pathway	19/711	109/7206	0.0137835992297
ko04960	Aldosterone-regulated sodium reabsorption	9/711	41/7206	0.0164494575833
ko04630	Jak-STAT signaling pathway	5/711	132/7206	0.0171255351171
ko00562	Inositol phosphate metabolism	16/711	89/7206	0.0179694007394
ko04930	Type II diabetes mellitus	11/711	54/7206	0.0183424273373
ko04640	Hematopoietic cell lineage	1/711	64/7206	0.0187658823132
ko00512	Mucin type O-glycan biosynthesis	7/711	29/7206	0.0199867797788
ko04923	Regulation of lipolysis in adipocytes	14/711	77/7206	0.0202699141247
ko03008	Ribosome biogenesis in eukaryotes	2/711	79/7206	0.0218022564242
ko05205	Proteoglycans in cancer	16/711	271/7206	0.0223348705254
ko00190	Oxidative phosphorylation	5/711	127/7206	0.0229098873519
ko04064	NF-kappa B signaling pathway	3/711	96/7206	0.0233850752542
ko04550	Signaling pathways regulating pluripotency of stem cells	8/711	165/7206	0.0245628780584
ko04918	Thyroid hormone synthesis	15/711	86/7206	0.026922720802
ko04330	Notch signaling pathway	1/711	62/7206	0.0287268781824
ko04916	Melanogenesis	22/711	142/7206	0.0316878934739
ko04722	Neurotrophin signaling pathway	24/711	160/7206	0.0320549325924
ko04940	Type I diabetes mellitus	7/711	32/7206	0.0333128813912
ko05214	Glioma	14/711	79/7206	0.0335987642194
ko05321	Inflammatory bowel disease (IBD)	1/711	56/7206	0.0400508909106
ko04062	Chemokine signaling pathway	29/711	201/7206	0.0401577359756
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/711	14/7206	0.042134070186
ko04666	Fc gamma R-mediated phagocytosis	19/711	122/7206	0.044581326161
ko00310	Lysine degradation	2/711	73/7206	0.0450663757376
ko04146	Peroxisome	3/711	89/7206	0.0460390699901
ko05222	Small cell lung cancer	3/711	89/7206	0.0460390699901