ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1136	423/7206	2.44810345035e-51
ko04724	Glutamatergic synapse	89/1136	152/7206	3.78312678844e-34
ko05033	Nicotine addiction	49/1136	56/7206	1.50221083972e-32
ko05032	Morphine addiction	69/1136	110/7206	2.91629468021e-29
ko04713	Circadian entrainment	75/1136	136/7206	1.41660783016e-26
ko04727	GABAergic synapse	66/1136	110/7206	2.09865203178e-26
ko04728	Dopaminergic synapse	85/1136	185/7206	8.42008522909e-23
ko04725	Cholinergic synapse	77/1136	160/7206	2.66838664125e-22
ko04723	Retrograde endocannabinoid signaling	79/1136	175/7206	1.15202319791e-20
ko04721	Synaptic vesicle cycle	49/1136	80/7206	1.92832650132e-20
ko04024	cAMP signaling pathway	105/1136	279/7206	1.3236795163e-19
ko04742	Taste transduction	38/1136	61/7206	1.74715996497e-16
ko04726	Serotonergic synapse	61/1136	137/7206	7.41595643075e-16
ko04020	Calcium signaling pathway	94/1136	265/7206	1.01360046189e-15
ko04911	Insulin secretion	54/1136	117/7206	5.41743772207e-15
ko04921	Oxytocin signaling pathway	78/1136	209/7206	1.78407449839e-14
ko04744	Phototransduction	26/1136	36/7206	5.49175696587e-14
ko05031	Amphetamine addiction	43/1136	91/7206	1.2361803014e-12
ko04720	Long-term potentiation	45/1136	99/7206	2.04909495327e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1136	205/7206	4.3233957429e-12
ko03040	Spliceosome	1/1136	145/7206	5.18440035438e-10
ko04970	Salivary secretion	39/1136	95/7206	2.45017090776e-09
ko04925	Aldosterone synthesis and secretion	41/1136	105/7206	5.62857464603e-09
ko05030	Cocaine addiction	32/1136	73/7206	9.90279668491e-09
ko04740	Olfactory transduction	33/1136	80/7206	3.62557468575e-08
ko04360	Axon guidance	69/1136	233/7206	6.72725599845e-08
ko05168	Herpes simplex infection	6/1136	182/7206	8.30942127976e-08
ko05203	Viral carcinogenesis	15/1136	277/7206	1.23394699507e-07
ko04971	Gastric acid secretion	37/1136	98/7206	1.32502019657e-07
ko04060	Cytokine-cytokine receptor interaction	8/1136	191/7206	5.46666634756e-07
ko04070	Phosphatidylinositol signaling system	39/1136	112/7206	5.64545779211e-07
ko05322	Systemic lupus erythematosus	5/1136	151/7206	1.3390210635e-06
ko04120	Ubiquitin mediated proteolysis	4/1136	138/7206	1.47831972641e-06
ko04010	MAPK signaling pathway	83/1136	321/7206	2.06299571733e-06
ko04022	cGMP-PKG signaling pathway	61/1136	216/7206	2.42895686802e-06
ko03013	RNA transport	7/1136	166/7206	4.1423190315e-06
ko05164	Influenza A	7/1136	167/7206	4.27901832801e-06
ko04141	Protein processing in endoplasmic reticulum	9/1136	184/7206	7.52983769027e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1136	74/7206	1.31434887329e-05
ko04514	Cell adhesion molecules (CAMs)	40/1136	130/7206	1.45730946689e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1136	79/7206	1.45797234916e-05
ko04730	Long-term depression	27/1136	78/7206	3.24083823633e-05
ko05414	Dilated cardiomyopathy	35/1136	112/7206	3.50509771928e-05
ko04621	NOD-like receptor signaling pathway	8/1136	157/7206	5.28448585066e-05
ko04072	Phospholipase D signaling pathway	53/1136	197/7206	5.96914383182e-05
ko04972	Pancreatic secretion	34/1136	111/7206	6.55573200686e-05
ko04540	Gap junction	38/1136	128/7206	6.60690300201e-05
ko04745	Phototransduction - fly	16/1136	38/7206	9.24407883279e-05
ko04924	Renin secretion	28/1136	86/7206	0.000131023614816
ko04014	Ras signaling pathway	68/1136	279/7206	0.000146451439315
ko04110	Cell cycle	8/1136	145/7206	0.000199778348197
ko04260	Cardiac muscle contraction	30/1136	98/7206	0.000210562375366
ko04915	Estrogen signaling pathway	37/1136	131/7206	0.000237596052392
ko04966	Collecting duct acid secretion	12/1136	26/7206	0.000248443139253
ko03008	Ribosome biogenesis in eukaryotes	2/1136	79/7206	0.000265845116561
ko05169	Epstein-Barr virus infection	15/1136	206/7206	0.000305630127547
ko04612	Antigen processing and presentation	2/1136	77/7206	0.000400323179975
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1136	59/7206	0.00048202431194
ko04750	Inflammatory mediator regulation of TRP channels	34/1136	122/7206	0.000605454432185
ko05110	Vibrio cholerae infection	21/1136	63/7206	0.000665606887156
ko00480	Glutathione metabolism	1/1136	55/7206	0.00134166860019
ko05162	Measles	7/1136	120/7206	0.0014092703569
ko04923	Regulation of lipolysis in adipocytes	23/1136	77/7206	0.00149070530542
ko04371	Apelin signaling pathway	44/1136	177/7206	0.00158678141283
ko04976	Bile secretion	24/1136	80/7206	0.00164527904364
ko05205	Proteoglycans in cancer	25/1136	271/7206	0.00210759348664
ko05140	Leishmaniasis	3/1136	75/7206	0.00223742359613
ko04064	NF-kappa B signaling pathway	5/1136	96/7206	0.00268089014887
ko04640	Hematopoietic cell lineage	2/1136	64/7206	0.00279656131716
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1136	14/7206	0.00293426203693
ko00590	Arachidonic acid metabolism	1/1136	52/7206	0.00323281640538
ko04626	Plant-pathogen interaction	8/1136	18/7206	0.00370241148568
ko05161	Hepatitis B	14/1136	173/7206	0.00408881352065
ko00260	Glycine, serine and threonine metabolism	1/1136	48/7206	0.00456571703868
ko00240	Pyrimidine metabolism	7/1136	110/7206	0.00511315665803
ko04146	Peroxisome	5/1136	89/7206	0.00511590267695
ko04912	GnRH signaling pathway	31/1136	122/7206	0.00545446385363
ko05144	Malaria	1/1136	45/7206	0.00680771908227
ko00071	Fatty acid degradation	1/1136	45/7206	0.00680771908227
ko03420	Nucleotide excision repair	1/1136	46/7206	0.00696206693853
ko04658	Th1 and Th2 cell differentiation	6/1136	96/7206	0.00701006103224
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1136	182/7206	0.00717413384952
ko00562	Inositol phosphate metabolism	24/1136	89/7206	0.00757965571143
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1136	100/7206	0.00801573427579
ko05166	HTLV-I infection	30/1136	292/7206	0.00846464035564
ko03018	RNA degradation	5/1136	84/7206	0.00986758337262
ko03022	Basal transcription factors	1/1136	44/7206	0.0107190990225
ko04330	Notch signaling pathway	3/1136	62/7206	0.0134677959899
ko04622	RIG-I-like receptor signaling pathway	3/1136	62/7206	0.0134677959899
ko05131	Shigellosis	5/1136	82/7206	0.0137550200748
ko04214	Apoptosis - fly	4/1136	72/7206	0.0138406429137
ko00310	Lysine degradation	4/1136	73/7206	0.014153274926
ko04015	Rap1 signaling pathway	59/1136	278/7206	0.0146166668045
ko05418	Fluid shear stress and atherosclerosis	16/1136	173/7206	0.0149569476885
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1136	40/7206	0.0152387909334
ko04630	Jak-STAT signaling pathway	11/1136	132/7206	0.015571841352
ko04657	IL-17 signaling pathway	6/1136	87/7206	0.0178171355994
ko05133	Pertussis	6/1136	87/7206	0.0178171355994
ko04062	Chemokine signaling pathway	44/1136	201/7206	0.0184350962096
ko00330	Arginine and proline metabolism	3/1136	61/7206	0.0198673540969
ko04350	TGF-beta signaling pathway	8/1136	103/7206	0.0206473819276
ko04722	Neurotrophin signaling pathway	36/1136	160/7206	0.0212327066421
ko05231	Choline metabolism in cancer	31/1136	134/7206	0.022633031122
ko00982	Drug metabolism - cytochrome P450	1/1136	37/7206	0.0226401881323
ko00630	Glyoxylate and dicarboxylate metabolism	1/1136	38/7206	0.0230377572126
ko01524	Platinum drug resistance	5/1136	76/7206	0.0256641145
ko05145	Toxoplasmosis	11/1136	126/7206	0.0262255848045
ko05321	Inflammatory bowel disease (IBD)	3/1136	56/7206	0.0269421911668
ko05034	Alcoholism	50/1136	238/7206	0.029510462776
ko04973	Carbohydrate digestion and absorption	12/1136	42/7206	0.0316304263246
ko04270	Vascular smooth muscle contraction	34/1136	154/7206	0.0336740632483
ko00860	Porphyrin and chlorophyll metabolism	1/1136	34/7206	0.0336877315587
ko04916	Melanogenesis	32/1136	142/7206	0.0352971043391
ko04115	p53 signaling pathway	5/1136	74/7206	0.0353785216088
ko04918	Thyroid hormone synthesis	21/1136	86/7206	0.0358002112885
ko04964	Proximal tubule bicarbonate reclamation	9/1136	29/7206	0.0365600696504
ko04217	Necroptosis	18/1136	178/7206	0.0368068058783
ko00280	Valine, leucine and isoleucine degradation	3/1136	54/7206	0.0379528475971
ko05215	Prostate cancer	10/1136	111/7206	0.048796960021