ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1015	423/7206	7.05889912938e-56
ko05033	Nicotine addiction	47/1015	56/7206	8.16509365531e-32
ko04724	Glutamatergic synapse	82/1015	152/7206	1.17922790563e-31
ko05032	Morphine addiction	63/1015	110/7206	1.78131910495e-26
ko04713	Circadian entrainment	69/1015	136/7206	1.14510388639e-24
ko04727	GABAergic synapse	61/1015	110/7206	1.24049946235e-24
ko04728	Dopaminergic synapse	81/1015	185/7206	2.28197065298e-23
ko04725	Cholinergic synapse	70/1015	160/7206	2.68940327069e-20
ko04723	Retrograde endocannabinoid signaling	73/1015	175/7206	1.16341279976e-19
ko04721	Synaptic vesicle cycle	45/1015	80/7206	8.39860761809e-19
ko04024	cAMP signaling pathway	96/1015	279/7206	1.87470006572e-18
ko04726	Serotonergic synapse	59/1015	137/7206	6.97517521482e-17
ko04020	Calcium signaling pathway	89/1015	265/7206	2.5809988756e-16
ko04742	Taste transduction	36/1015	61/7206	3.29161604908e-16
ko04911	Insulin secretion	51/1015	117/7206	5.11968179701e-15
ko04921	Oxytocin signaling pathway	72/1015	209/7206	4.86233612227e-14
ko04744	Phototransduction	24/1015	36/7206	6.69313671266e-13
ko05031	Amphetamine addiction	39/1015	91/7206	1.66342081637e-11
ko04720	Long-term potentiation	41/1015	99/7206	1.8959173695e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/1015	205/7206	5.49486785642e-10
ko03040	Spliceosome	1/1015	145/7206	9.02734583562e-09
ko04970	Salivary secretion	35/1015	95/7206	2.24399594483e-08
ko05030	Cocaine addiction	29/1015	73/7206	5.29478713591e-08
ko05203	Viral carcinogenesis	12/1015	277/7206	1.29997875683e-07
ko04740	Olfactory transduction	30/1015	80/7206	1.44188825176e-07
ko04925	Aldosterone synthesis and secretion	35/1015	105/7206	4.98499648935e-07
ko04360	Axon guidance	61/1015	233/7206	7.13044573688e-07
ko04971	Gastric acid secretion	33/1015	98/7206	9.5770609805e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1015	74/7206	1.14076922452e-06
ko05168	Herpes simplex infection	6/1015	182/7206	1.41532397973e-06
ko04010	MAPK signaling pathway	77/1015	321/7206	1.46895044436e-06
ko05164	Influenza A	5/1015	167/7206	2.44034394264e-06
ko03013	RNA transport	6/1015	166/7206	1.26338510486e-05
ko05322	Systemic lupus erythematosus	5/1015	151/7206	1.49958530902e-05
ko04745	Phototransduction - fly	16/1015	38/7206	2.24329783678e-05
ko04060	Cytokine-cytokine receptor interaction	9/1015	191/7206	3.26269207537e-05
ko04514	Cell adhesion molecules (CAMs)	36/1015	130/7206	3.6624074919e-05
ko04022	cGMP-PKG signaling pathway	53/1015	216/7206	3.71447820621e-05
ko04070	Phosphatidylinositol signaling system	32/1015	112/7206	5.19648337326e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1015	79/7206	5.41222237703e-05
ko04540	Gap junction	35/1015	128/7206	8.5956444881e-05
ko04120	Ubiquitin mediated proteolysis	5/1015	138/7206	9.55532806502e-05
ko04014	Ras signaling pathway	63/1015	279/7206	9.83413125621e-05
ko04924	Renin secretion	26/1015	86/7206	0.000111953633837
ko04730	Long-term depression	24/1015	78/7206	0.000118911193612
ko04972	Pancreatic secretion	31/1015	111/7206	0.000145425525667
ko04260	Cardiac muscle contraction	28/1015	98/7206	0.000178959042814
ko04141	Protein processing in endoplasmic reticulum	10/1015	184/7206	0.000229755046784
ko04750	Inflammatory mediator regulation of TRP channels	32/1015	122/7206	0.000328150405206
ko04072	Phospholipase D signaling pathway	46/1015	197/7206	0.000373118685539
ko04966	Collecting duct acid secretion	11/1015	26/7206	0.000416086102244
ko04110	Cell cycle	7/1015	145/7206	0.00042244654243
ko04621	NOD-like receptor signaling pathway	8/1015	157/7206	0.000434070503789
ko05169	Epstein-Barr virus infection	13/1015	206/7206	0.0005119523576
ko05161	Hepatitis B	10/1015	173/7206	0.000799379326892
ko05414	Dilated cardiomyopathy	29/1015	112/7206	0.000850133057254
ko04610	Complement and coagulation cascades	2/1015	79/7206	0.000953307342395
ko03008	Ribosome biogenesis in eukaryotes	2/1015	79/7206	0.000953307342395
ko04612	Antigen processing and presentation	2/1015	77/7206	0.00141579742077
ko04626	Plant-pathogen interaction	8/1015	18/7206	0.00177452660613
ko05162	Measles	6/1015	120/7206	0.00211448639183
ko05140	Leishmaniasis	2/1015	75/7206	0.00214036400257
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1015	182/7206	0.00230983423513
ko04064	NF-kappa B signaling pathway	4/1015	96/7206	0.00274628432168
ko05110	Vibrio cholerae infection	18/1015	63/7206	0.00279413218535
ko05205	Proteoglycans in cancer	22/1015	271/7206	0.00316104788174
ko04915	Estrogen signaling pathway	31/1015	131/7206	0.00319135358102
ko04976	Bile secretion	21/1015	80/7206	0.0033424761816
ko05166	HTLV-I infection	25/1015	292/7206	0.00446390865333
ko04630	Jak-STAT signaling pathway	8/1015	132/7206	0.0051562499163
ko00480	Glutathione metabolism	1/1015	55/7206	0.00519441437537
ko04146	Peroxisome	4/1015	89/7206	0.00538370509753
ko00240	Pyrimidine metabolism	6/1015	110/7206	0.00550648899482
ko04640	Hematopoietic cell lineage	2/1015	64/7206	0.00630557064619
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1015	59/7206	0.0075014829306
ko04015	Rap1 signaling pathway	55/1015	278/7206	0.00807376293223
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1015	14/7206	0.00841038615049
ko00330	Arginine and proline metabolism	2/1015	61/7206	0.00913845330135
ko04330	Notch signaling pathway	2/1015	62/7206	0.0092076027537
ko00310	Lysine degradation	3/1015	73/7206	0.0102170108928
ko03018	RNA degradation	4/1015	84/7206	0.0106583286037
ko05016	Huntington's disease	18/1015	215/7206	0.0125906415521
ko04670	Leukocyte transendothelial migration	11/1015	151/7206	0.0126837750018
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1015	100/7206	0.0136074670704
ko00562	Inositol phosphate metabolism	21/1015	89/7206	0.0136695959587
ko04964	Proximal tubule bicarbonate reclamation	9/1015	29/7206	0.015022891843
ko03022	Basal transcription factors	1/1015	44/7206	0.0161708373293
ko05144	Malaria	1/1015	45/7206	0.0162862494226
ko00071	Fatty acid degradation	1/1015	45/7206	0.0162862494226
ko00620	Pyruvate metabolism	1/1015	46/7206	0.0167941921827
ko03420	Nucleotide excision repair	1/1015	46/7206	0.0167941921827
ko04912	GnRH signaling pathway	27/1015	122/7206	0.0171320117555
ko04930	Type II diabetes mellitus	14/1015	54/7206	0.0177492506534
ko05418	Fluid shear stress and atherosclerosis	14/1015	173/7206	0.0198260880948
ko01200	Carbon metabolism	9/1015	128/7206	0.0201513214953
ko04114	Oocyte meiosis	29/1015	139/7206	0.0260712643089
ko01524	Platinum drug resistance	4/1015	76/7206	0.0291140420253
ko04350	TGF-beta signaling pathway	7/1015	103/7206	0.031458954875
ko03410	Base excision repair	1/1015	38/7206	0.0353958036457
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1015	40/7206	0.0364829182003
ko05034	Alcoholism	45/1015	238/7206	0.0365436829881
ko05131	Shigellosis	5/1015	82/7206	0.0366787568581
ko04371	Apelin signaling pathway	35/1015	177/7206	0.0367649859445
ko05215	Prostate cancer	8/1015	111/7206	0.0379592285073
ko04214	Apoptosis - fly	4/1015	72/7206	0.03909024641
ko04622	RIG-I-like receptor signaling pathway	3/1015	62/7206	0.0409667858558
ko04933	AGE-RAGE signaling pathway in diabetic complications	11/1015	135/7206	0.0452945843495
ko04510	Focal adhesion	23/1015	240/7206	0.0468110719439
ko04217	Necroptosis	16/1015	178/7206	0.049142596474