ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 47/245 145/7206 2.17259547583e-34 ko03460 Fanconi anemia pathway 27/245 51/7206 5.96820193848e-27 ko03030 DNA replication 22/245 38/7206 2.64166626115e-23 ko04111 Cell cycle - yeast 30/245 90/7206 1.68033549624e-22 ko03440 Homologous recombination 21/245 41/7206 9.07537523295e-21 ko04113 Meiosis - yeast 21/245 70/7206 5.40130575249e-15 ko03430 Mismatch repair 11/245 22/7206 2.84788631871e-11 ko03410 Base excision repair 13/245 38/7206 1.50226267904e-10 ko00240 Pyrimidine metabolism 18/245 110/7206 2.40932514282e-08 ko03420 Nucleotide excision repair 12/245 46/7206 2.54173050467e-08 ko04114 Oocyte meiosis 18/245 139/7206 9.26349729321e-07 ko03040 Spliceosome 18/245 145/7206 1.73498658974e-06 ko04218 Cellular senescence 19/245 177/7206 7.95710155617e-06 ko03008 Ribosome biogenesis in eukaryotes 11/245 79/7206 6.54881332179e-05 ko05166 HTLV-I infection 23/245 292/7206 0.000170478559506 ko04115 p53 signaling pathway 10/245 74/7206 0.000181750542268 ko04914 Progesterone-mediated oocyte maturation 12/245 104/7206 0.000196015224734 ko04151 PI3K-Akt signaling pathway 2/245 390/7206 0.000242385500259 ko04014 Ras signaling pathway 1/245 279/7206 0.00109345562526 ko04120 Ubiquitin mediated proteolysis 12/245 138/7206 0.00248992311589 ko04510 Focal adhesion 1/245 240/7206 0.00340201243519 ko04360 Axon guidance 1/245 233/7206 0.00499614877177 ko04015 Rap1 signaling pathway 2/245 278/7206 0.00627464964909 ko04024 cAMP signaling pathway 2/245 279/7206 0.00629127695763 ko04010 MAPK signaling pathway 3/245 321/7206 0.00702564921595 ko05205 Proteoglycans in cancer 2/245 271/7206 0.00912470404869 ko05206 MicroRNAs in cancer 13/245 177/7206 0.00917033548978 ko04261 Adrenergic signaling in cardiomyocytes 1/245 205/7206 0.0104438723613 ko04921 Oxytocin signaling pathway 1/245 209/7206 0.0105108970127 ko04022 cGMP-PKG signaling pathway 1/245 216/7206 0.0111370761629 ko00270 Cysteine and methionine metabolism 5/245 47/7206 0.0209110979612 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/245 182/7206 0.0218232164939 ko04728 Dopaminergic synapse 1/245 185/7206 0.0219365479636 ko00230 Purine metabolism 13/245 194/7206 0.0236490794086 ko04530 Tight junction 2/245 228/7206 0.0250512785654 ko05222 Small cell lung cancer 7/245 89/7206 0.0312872628547 ko04723 Retrograde endocannabinoid signaling 1/245 175/7206 0.0318577210219 ko04371 Apelin signaling pathway 1/245 177/7206 0.0322686033518 ko03015 mRNA surveillance pathway 7/245 93/7206 0.0384349834268 ko05203 Viral carcinogenesis 16/245 277/7206 0.0396061708074 ko04722 Neurotrophin signaling pathway 1/245 160/7206 0.0452571078006 ko04725 Cholinergic synapse 1/245 160/7206 0.0452571078006 ko04152 AMPK signaling pathway 1/245 161/7206 0.0453695077482 ko04145 Phagosome 1/245 162/7206 0.0455292144983 ko04071 Sphingolipid signaling pathway 1/245 162/7206 0.0455292144983 ko04140 Autophagy - animal 1/245 164/7206 0.0459900217363