ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1233	423/7206	1.15879845723e-51
ko04724	Glutamatergic synapse	90/1233	152/7206	3.65185686917e-32
ko05033	Nicotine addiction	49/1233	56/7206	8.10847569571e-31
ko05032	Morphine addiction	71/1233	110/7206	6.46154227277e-29
ko04727	GABAergic synapse	67/1233	110/7206	3.49750719728e-25
ko04713	Circadian entrainment	76/1233	136/7206	4.78809043017e-25
ko04728	Dopaminergic synapse	89/1233	185/7206	5.32113694989e-23
ko04721	Synaptic vesicle cycle	52/1233	80/7206	1.12105078561e-21
ko04725	Cholinergic synapse	78/1233	160/7206	1.00340459913e-20
ko04723	Retrograde endocannabinoid signaling	80/1233	175/7206	4.72644248989e-19
ko04020	Calcium signaling pathway	105/1233	265/7206	7.81780984896e-19
ko04024	cAMP signaling pathway	108/1233	279/7206	1.72776392711e-18
ko04742	Taste transduction	39/1233	61/7206	3.38799689905e-16
ko04921	Oxytocin signaling pathway	84/1233	209/7206	1.13471452823e-15
ko04726	Serotonergic synapse	63/1233	137/7206	2.12876685602e-15
ko04911	Insulin secretion	56/1233	117/7206	9.1785960345e-15
ko04744	Phototransduction	26/1233	36/7206	4.0558395977e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1233	205/7206	1.17674614244e-12
ko05031	Amphetamine addiction	44/1233	91/7206	4.56700535421e-12
ko04970	Salivary secretion	45/1233	95/7206	6.4363431013e-12
ko04720	Long-term potentiation	46/1233	99/7206	8.77483706026e-12
ko03040	Spliceosome	1/1233	145/7206	7.25152522695e-11
ko05203	Viral carcinogenesis	15/1233	277/7206	4.48356380128e-09
ko04925	Aldosterone synthesis and secretion	43/1233	105/7206	7.93172624977e-09
ko04360	Axon guidance	74/1233	233/7206	2.49525789528e-08
ko04060	Cytokine-cytokine receptor interaction	8/1233	191/7206	4.99108533907e-08
ko04971	Gastric acid secretion	39/1233	98/7206	8.16325231855e-08
ko04022	cGMP-PKG signaling pathway	68/1233	216/7206	1.71880969165e-07
ko04070	Phosphatidylinositol signaling system	42/1233	112/7206	1.82902767735e-07
ko04740	Olfactory transduction	33/1233	80/7206	2.7221342516e-07
ko05030	Cocaine addiction	31/1233	73/7206	2.87267938011e-07
ko03013	RNA transport	7/1233	166/7206	5.72863760339e-07
ko05322	Systemic lupus erythematosus	6/1233	151/7206	9.754632473e-07
ko05168	Herpes simplex infection	9/1233	182/7206	1.1099486283e-06
ko04010	MAPK signaling pathway	88/1233	321/7206	2.18185388543e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1233	74/7206	2.3304421359e-06
ko04924	Renin secretion	32/1233	86/7206	7.63668825931e-06
ko05164	Influenza A	9/1233	167/7206	9.10973913797e-06
ko04966	Collecting duct acid secretion	14/1233	26/7206	2.14119719408e-05
ko04972	Pancreatic secretion	37/1233	111/7206	3.21571600328e-05
ko04540	Gap junction	41/1233	128/7206	4.09601688345e-05
ko04514	Cell adhesion molecules (CAMs)	41/1233	130/7206	4.82735036308e-05
ko04730	Long-term depression	28/1233	78/7206	5.51594705014e-05
ko05110	Vibrio cholerae infection	24/1233	63/7206	6.21051213053e-05
ko04745	Phototransduction - fly	17/1233	38/7206	6.40635513589e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1233	59/7206	6.6227739426e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1233	79/7206	6.84971435604e-05
ko04141	Protein processing in endoplasmic reticulum	13/1233	184/7206	9.28691363494e-05
ko04621	NOD-like receptor signaling pathway	10/1233	157/7206	9.61795345147e-05
ko05169	Epstein-Barr virus infection	16/1233	206/7206	0.000108706965796
ko03008	Ribosome biogenesis in eukaryotes	2/1233	79/7206	0.000113366040439
ko04120	Ubiquitin mediated proteolysis	8/1233	138/7206	0.000132576413574
ko05414	Dilated cardiomyopathy	35/1233	112/7206	0.000200753397051
ko04072	Phospholipase D signaling pathway	54/1233	197/7206	0.000239626158344
ko04976	Bile secretion	27/1233	80/7206	0.000259288666494
ko04014	Ras signaling pathway	71/1233	279/7206	0.000334535499853
ko04260	Cardiac muscle contraction	31/1233	98/7206	0.000366218740292
ko04110	Cell cycle	10/1233	145/7206	0.000481049024544
ko05205	Proteoglycans in cancer	26/1233	271/7206	0.000516024701964
ko04750	Inflammatory mediator regulation of TRP channels	36/1233	122/7206	0.000600553754722
ko04612	Antigen processing and presentation	3/1233	77/7206	0.000674398548262
ko05140	Leishmaniasis	3/1233	75/7206	0.000989847442623
ko04640	Hematopoietic cell lineage	2/1233	64/7206	0.00119478374547
ko05162	Measles	8/1233	120/7206	0.0013035909225
ko04626	Plant-pathogen interaction	9/1233	18/7206	0.00135360926076
ko04371	Apelin signaling pathway	47/1233	177/7206	0.00158922236052
ko04964	Proximal tubule bicarbonate reclamation	12/1233	29/7206	0.00177523529939
ko04923	Regulation of lipolysis in adipocytes	24/1233	77/7206	0.00209346050274
ko04064	NF-kappa B signaling pathway	6/1233	96/7206	0.00248293415107
ko04146	Peroxisome	5/1233	89/7206	0.00253589746573
ko03420	Nucleotide excision repair	1/1233	46/7206	0.00281801669935
ko04915	Estrogen signaling pathway	36/1233	131/7206	0.00311872995308
ko00480	Glutathione metabolism	2/1233	55/7206	0.00373927226461
ko05321	Inflammatory bowel disease (IBD)	2/1233	56/7206	0.00375213283672
ko05161	Hepatitis B	16/1233	173/7206	0.00405647108086
ko03022	Basal transcription factors	1/1233	44/7206	0.00424895176302
ko05144	Malaria	1/1233	45/7206	0.00437422660431
ko00071	Fatty acid degradation	1/1233	45/7206	0.00437422660431
ko00240	Pyrimidine metabolism	8/1233	110/7206	0.00457014771177
ko00310	Lysine degradation	4/1233	73/7206	0.00466499368609
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1233	14/7206	0.00474472881989
ko04918	Thyroid hormone synthesis	25/1233	86/7206	0.00563270137531
ko04622	RIG-I-like receptor signaling pathway	3/1233	62/7206	0.00622520690091
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1233	100/7206	0.00685894883746
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1233	182/7206	0.00696991274152
ko00590	Arachidonic acid metabolism	2/1233	52/7206	0.00832932772397
ko04270	Vascular smooth muscle contraction	39/1233	154/7206	0.0090823211603
ko04657	IL-17 signaling pathway	6/1233	87/7206	0.00919647244262
ko05133	Pertussis	6/1233	87/7206	0.00919647244262
ko00330	Arginine and proline metabolism	3/1233	61/7206	0.00923704985796
ko00562	Inositol phosphate metabolism	25/1233	89/7206	0.00995657936638
ko05166	HTLV-I infection	34/1233	292/7206	0.0109149064614
ko00260	Glycine, serine and threonine metabolism	2/1233	48/7206	0.011723014621
ko05219	Bladder cancer	2/1233	48/7206	0.011723014621
ko03018	RNA degradation	6/1233	84/7206	0.0124928063995
ko04115	p53 signaling pathway	5/1233	74/7206	0.0129254517531
ko04630	Jak-STAT signaling pathway	12/1233	132/7206	0.0136521846241
ko05231	Choline metabolism in cancer	34/1233	134/7206	0.0145213022533
ko05131	Shigellosis	6/1233	82/7206	0.0172127319952
ko04214	Apoptosis - fly	5/1233	72/7206	0.0177999437939
ko04658	Th1 and Th2 cell differentiation	8/1233	96/7206	0.0197285704467
ko04217	Necroptosis	19/1233	178/7206	0.0201004909014
ko04912	GnRH signaling pathway	31/1233	122/7206	0.0204269086648
ko00500	Starch and sucrose metabolism	1/1233	35/7206	0.0219642016305
ko04015	Rap1 signaling pathway	62/1233	278/7206	0.0227380399523
ko04973	Carbohydrate digestion and absorption	13/1233	42/7206	0.0232132588131
ko04916	Melanogenesis	35/1233	142/7206	0.0236061460881
ko04922	Glucagon signaling pathway	32/1233	128/7206	0.0236306692124
ko03320	PPAR signaling pathway	5/1233	69/7206	0.0244784029872
ko04620	Toll-like receptor signaling pathway	9/1233	100/7206	0.0314126055793
ko04140	Autophagy - animal	18/1233	164/7206	0.0354924216387
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1233	40/7206	0.0359611222678
ko00380	Tryptophan metabolism	3/1233	50/7206	0.0365941403843
ko04710	Circadian rhythm	13/1233	43/7206	0.0387780591552
ko04114	Oocyte meiosis	33/1233	139/7206	0.0405658222775
ko05132	Salmonella infection	9/1233	98/7206	0.041438551524
ko05215	Prostate cancer	11/1233	111/7206	0.0418781632561
ko05145	Toxoplasmosis	13/1233	126/7206	0.041995227466
ko00230	Purine metabolism	44/1233	194/7206	0.0421004453191
ko04350	TGF-beta signaling pathway	10/1233	103/7206	0.0472677578212
ko05320	Autoimmune thyroid disease	1/1233	29/7206	0.0481564148871
ko05340	Primary immunodeficiency	1/1233	30/7206	0.0487480427072