ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 11/196 30/7206 1.58513170359e-10 ko04060 Cytokine-cytokine receptor interaction 23/196 191/7206 1.45334542265e-09 ko04380 Osteoclast differentiation 18/196 134/7206 1.75504065051e-08 ko05152 Tuberculosis 20/196 187/7206 1.37484054456e-07 ko04612 Antigen processing and presentation 12/196 77/7206 9.13878451599e-07 ko04660 T cell receptor signaling pathway 15/196 124/7206 1.1376423097e-06 ko04145 Phagosome 17/196 162/7206 1.64058809539e-06 ko04650 Natural killer cell mediated cytotoxicity 13/196 97/7206 1.87901983024e-06 ko04062 Chemokine signaling pathway 19/196 201/7206 1.940252745e-06 ko05164 Influenza A 17/196 167/7206 2.50697108489e-06 ko04620 Toll-like receptor signaling pathway 13/196 100/7206 2.66835715684e-06 ko05162 Measles 14/196 120/7206 4.05255613351e-06 ko05150 Staphylococcus aureus infection 8/196 36/7206 4.08583076155e-06 ko05140 Leishmaniasis 11/196 75/7206 4.87106928144e-06 ko04621 NOD-like receptor signaling pathway 16/196 157/7206 4.93882547505e-06 ko04670 Leukocyte transendothelial migration 15/196 151/7206 1.34771132607e-05 ko05144 Malaria 8/196 45/7206 2.35896846699e-05 ko04666 Fc gamma R-mediated phagocytosis 13/196 122/7206 2.43801711692e-05 ko05168 Herpes simplex infection 16/196 182/7206 3.22891255366e-05 ko05330 Allograft rejection 6/196 24/7206 3.35335557215e-05 ko05145 Toxoplasmosis 13/196 126/7206 3.44505218843e-05 ko04672 Intestinal immune network for IgA production 7/196 37/7206 5.09549190121e-05 ko05320 Autoimmune thyroid disease 6/196 29/7206 0.000105648830422 ko05321 Inflammatory bowel disease (IBD) 8/196 56/7206 0.000120322651689 ko04658 Th1 and Th2 cell differentiation 10/196 96/7206 0.000259951425061 ko05133 Pertussis 9/196 87/7206 0.000556210232702 ko04217 Necroptosis 13/196 178/7206 0.00108000682435 ko04664 Fc epsilon RI signaling pathway 8/196 77/7206 0.00109507635076 ko04064 NF-kappa B signaling pathway 9/196 96/7206 0.00113954535022 ko05332 Graft-versus-host disease 4/196 18/7206 0.00120386836739 ko04610 Complement and coagulation cascades 8/196 79/7206 0.00129635741529 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/196 191/7206 0.00204600330754 ko04659 Th17 cell differentiation 9/196 106/7206 0.00228645470894 ko05161 Hepatitis B 12/196 173/7206 0.00258219593985 ko04142 Lysosome 11/196 151/7206 0.00264450030297 ko04514 Cell adhesion molecules (CAMs) 10/196 130/7206 0.00276307524921 ko05323 Rheumatoid arthritis 8/196 89/7206 0.00278600665378 ko04630 Jak-STAT signaling pathway 10/196 132/7206 0.00308862730514 ko04622 RIG-I-like receptor signaling pathway 6/196 62/7206 0.00650543836337 ko05142 Chagas disease (American trypanosomiasis) 9/196 130/7206 0.00878531998963 ko04662 B cell receptor signaling pathway 7/196 88/7206 0.00979926865321 ko05310 Asthma 3/196 17/7206 0.0101697683068 ko04940 Type I diabetes mellitus 4/196 32/7206 0.0105168952204 ko04020 Calcium signaling pathway 1/196 265/7206 0.0106759889238 ko03050 Proteasome 5/196 54/7206 0.0152116499935 ko00120 Primary bile acid biosynthesis 3/196 20/7206 0.0160613106984 ko05416 Viral myocarditis 5/196 55/7206 0.0163740412521 ko05020 Prion diseases 4/196 40/7206 0.0226013643074 ko05034 Alcoholism 1/196 238/7206 0.0227298643018 ko04640 Hematopoietic cell lineage 5/196 64/7206 0.0295488612646 ko04933 AGE-RAGE signaling pathway in diabetic complications 8/196 135/7206 0.0305142850728 ko04210 Apoptosis 10/196 180/7206 0.0312659085471 ko05016 Huntington's disease 1/196 215/7206 0.0315756507094 ko05160 Hepatitis C 9/196 153/7206 0.0374505430012 ko04611 Platelet activation 9/196 163/7206 0.043988693854 ko04080 Neuroactive ligand-receptor interaction 5/196 423/7206 0.0440527799049