ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1099	423/7206	2.51188752803e-47
ko04724	Glutamatergic synapse	82/1099	152/7206	4.04405114242e-29
ko05033	Nicotine addiction	44/1099	56/7206	4.78402801603e-26
ko05032	Morphine addiction	62/1099	110/7206	1.27575775962e-23
ko04728	Dopaminergic synapse	84/1099	185/7206	4.12898287075e-23
ko04721	Synaptic vesicle cycle	50/1099	80/7206	4.69920622671e-22
ko04727	GABAergic synapse	59/1099	110/7206	4.67510782123e-21
ko04713	Circadian entrainment	67/1099	136/7206	4.67964227126e-21
ko04725	Cholinergic synapse	71/1099	160/7206	5.43921134068e-19
ko04723	Retrograde endocannabinoid signaling	71/1099	175/7206	2.0395428589e-16
ko04024	cAMP signaling pathway	96/1099	279/7206	5.04170136264e-16
ko04911	Insulin secretion	54/1099	117/7206	1.26160854468e-15
ko04742	Taste transduction	35/1099	61/7206	3.47265117987e-14
ko04020	Calcium signaling pathway	88/1099	265/7206	9.31315774107e-14
ko04726	Serotonergic synapse	55/1099	137/7206	9.21858365903e-13
ko04921	Oxytocin signaling pathway	73/1099	209/7206	1.16269977848e-12
ko05031	Amphetamine addiction	40/1099	91/7206	4.42237399393e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1099	205/7206	7.74078442066e-11
ko04970	Salivary secretion	40/1099	95/7206	2.21378167522e-10
ko03040	Spliceosome	1/1099	145/7206	1.35131962101e-09
ko04360	Axon guidance	71/1099	233/7206	2.37527782198e-09
ko04744	Phototransduction	21/1099	36/7206	3.30446718428e-09
ko04720	Long-term potentiation	39/1099	99/7206	3.78884067836e-09
ko05203	Viral carcinogenesis	14/1099	277/7206	8.79764225144e-08
ko04971	Gastric acid secretion	36/1099	98/7206	2.05909917515e-07
ko05030	Cocaine addiction	29/1099	73/7206	3.08910793343e-07
ko04022	cGMP-PKG signaling pathway	61/1099	216/7206	6.60441418881e-07
ko05168	Herpes simplex infection	7/1099	182/7206	1.02833110022e-06
ko04925	Aldosterone synthesis and secretion	36/1099	105/7206	1.39378940352e-06
ko03013	RNA transport	6/1099	166/7206	1.78107877014e-06
ko04010	MAPK signaling pathway	81/1099	321/7206	2.19729627063e-06
ko05322	Systemic lupus erythematosus	5/1099	151/7206	3.04087758408e-06
ko04120	Ubiquitin mediated proteolysis	4/1099	138/7206	3.42080608031e-06
ko04740	Olfactory transduction	29/1099	80/7206	4.51437999948e-06
ko04060	Cytokine-cytokine receptor interaction	9/1099	191/7206	5.38934628131e-06
ko04966	Collecting duct acid secretion	14/1099	26/7206	5.40326995183e-06
ko04924	Renin secretion	30/1099	86/7206	5.43017874382e-06
ko04621	NOD-like receptor signaling pathway	6/1099	157/7206	8.07046096351e-06
ko05164	Influenza A	7/1099	167/7206	9.22832606709e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1099	74/7206	2.22438346933e-05
ko04540	Gap junction	38/1099	128/7206	2.92902477634e-05
ko04514	Cell adhesion molecules (CAMs)	38/1099	130/7206	3.77158588987e-05
ko04141	Protein processing in endoplasmic reticulum	10/1099	184/7206	4.23689660928e-05
ko04972	Pancreatic secretion	34/1099	111/7206	4.29620932097e-05
ko04745	Phototransduction - fly	16/1099	38/7206	6.12978639082e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1099	79/7206	9.45645794791e-05
ko04070	Phosphatidylinositol signaling system	33/1099	112/7206	0.000100429471983
ko04014	Ras signaling pathway	66/1099	279/7206	0.000168570163704
ko04730	Long-term depression	25/1099	78/7206	0.000178868774983
ko05110	Vibrio cholerae infection	21/1099	63/7206	0.000290427469139
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1099	59/7206	0.000338330242494
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1099	14/7206	0.000362585156172
ko03008	Ribosome biogenesis in eukaryotes	2/1099	79/7206	0.000409419035553
ko05205	Proteoglycans in cancer	22/1099	271/7206	0.000527388999237
ko04260	Cardiac muscle contraction	28/1099	98/7206	0.000602881443748
ko04612	Antigen processing and presentation	2/1099	77/7206	0.000617043973158
ko05414	Dilated cardiomyopathy	31/1099	112/7206	0.000760441340811
ko04750	Inflammatory mediator regulation of TRP channels	33/1099	122/7206	0.000802874952525
ko05161	Hepatitis B	12/1099	173/7206	0.00121130428575
ko00480	Glutathione metabolism	1/1099	55/7206	0.00208676247333
ko04072	Phospholipase D signaling pathway	46/1099	197/7206	0.0024168366205
ko04146	Peroxisome	4/1099	89/7206	0.00259964779234
ko05169	Epstein-Barr virus infection	17/1099	206/7206	0.00309547149032
ko00590	Arachidonic acid metabolism	1/1099	52/7206	0.00311475763481
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1099	182/7206	0.00322226057653
ko05140	Leishmaniasis	3/1099	75/7206	0.00330823447003
ko04064	NF-kappa B signaling pathway	5/1099	96/7206	0.0038102093001
ko04640	Hematopoietic cell lineage	2/1099	64/7206	0.00431362813495
ko04630	Jak-STAT signaling pathway	9/1099	132/7206	0.00464339346862
ko00310	Lysine degradation	3/1099	73/7206	0.00478343113423
ko04371	Apelin signaling pathway	41/1099	177/7206	0.00557361540595
ko00330	Arginine and proline metabolism	2/1099	61/7206	0.0062093409347
ko05162	Measles	8/1099	120/7206	0.00666720249148
ko03420	Nucleotide excision repair	1/1099	46/7206	0.00697389489508
ko00240	Pyrimidine metabolism	7/1099	110/7206	0.0069876725207
ko05219	Bladder cancer	1/1099	48/7206	0.0072774563012
ko04964	Proximal tubule bicarbonate reclamation	10/1099	29/7206	0.00821762388379
ko04915	Estrogen signaling pathway	31/1099	131/7206	0.00972889181011
ko01524	Platinum drug resistance	4/1099	76/7206	0.0100719465094
ko03022	Basal transcription factors	1/1099	44/7206	0.0104201847568
ko04015	Rap1 signaling pathway	58/1099	278/7206	0.0104930271416
ko05144	Malaria	1/1099	45/7206	0.010705504439
ko00071	Fatty acid degradation	1/1099	45/7206	0.010705504439
ko04976	Bile secretion	21/1099	80/7206	0.0111812019177
ko04270	Vascular smooth muscle contraction	35/1099	154/7206	0.012360173148
ko00280	Valine, leucine and isoleucine degradation	2/1099	54/7206	0.0126374162876
ko04626	Plant-pathogen interaction	7/1099	18/7206	0.0128146145073
ko03018	RNA degradation	5/1099	84/7206	0.0138847205428
ko04668	TNF signaling pathway	9/1099	120/7206	0.0145608853526
ko00140	Steroid hormone biosynthesis	1/1099	41/7206	0.0154916948148
ko05215	Prostate cancer	8/1099	111/7206	0.0158921425911
ko04620	Toll-like receptor signaling pathway	7/1099	100/7206	0.0170050799122
ko05145	Toxoplasmosis	10/1099	126/7206	0.0174940418551
ko01200	Carbon metabolism	10/1099	128/7206	0.0176635769001
ko04916	Melanogenesis	32/1099	142/7206	0.0182492593023
ko04110	Cell cycle	12/1099	145/7206	0.0188446707443
ko05131	Shigellosis	5/1099	82/7206	0.0192705262564
ko04217	Necroptosis	16/1099	178/7206	0.0195771571567
ko04622	RIG-I-like receptor signaling pathway	3/1099	62/7206	0.0196241268577
ko04214	Apoptosis - fly	4/1099	72/7206	0.0197594006368
ko03410	Base excision repair	1/1099	38/7206	0.0230385563361
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1099	100/7206	0.0236986161419
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1099	40/7206	0.0241407140813
ko05133	Pertussis	6/1099	87/7206	0.0245062918647
ko05166	HTLV-I infection	31/1099	292/7206	0.0245615989249
ko04923	Regulation of lipolysis in adipocytes	19/1099	77/7206	0.0256555278994
ko00380	Tryptophan metabolism	2/1099	50/7206	0.027257684044
ko04140	Autophagy - animal	15/1099	164/7206	0.0274796154397
ko04658	Th1 and Th2 cell differentiation	7/1099	96/7206	0.0307386907492
ko00982	Drug metabolism - cytochrome P450	1/1099	37/7206	0.03533259684
ko04930	Type II diabetes mellitus	14/1099	54/7206	0.0359154726915
ko00620	Pyruvate metabolism	2/1099	46/7206	0.0379888522819
ko04391	Hippo signaling pathway - fly	21/1099	90/7206	0.0383316520865
ko05321	Inflammatory bowel disease (IBD)	3/1099	56/7206	0.0385871775017
ko04912	GnRH signaling pathway	27/1099	122/7206	0.0412153293998
ko05016	Huntington's disease	22/1099	215/7206	0.0424471698889
ko04115	p53 signaling pathway	5/1099	74/7206	0.048946539305