ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 71/378 145/7206 1.82375322925e-53 ko03008 Ribosome biogenesis in eukaryotes 43/378 79/7206 6.22566225238e-35 ko03013 RNA transport 53/378 166/7206 1.95488388272e-28 ko03020 RNA polymerase 15/378 29/7206 1.88833778606e-12 ko04110 Cell cycle 31/378 145/7206 9.7944823133e-12 ko00240 Pyrimidine metabolism 26/378 110/7206 4.55581806889e-11 ko03030 DNA replication 15/378 38/7206 2.43634734687e-10 ko03015 mRNA surveillance pathway 22/378 93/7206 1.45487712251e-09 ko04080 Neuroactive ligand-receptor interaction 1/378 423/7206 3.05915526621e-09 ko03018 RNA degradation 19/378 84/7206 4.30097872838e-08 ko04111 Cell cycle - yeast 18/378 90/7206 7.03058499853e-07 ko04144 Endocytosis 2/378 342/7206 2.49958435498e-06 ko04810 Regulation of actin cytoskeleton 1/378 264/7206 1.49126889238e-05 ko04020 Calcium signaling pathway 1/378 265/7206 1.50564056633e-05 ko04113 Meiosis - yeast 13/378 70/7206 5.733375778e-05 ko04360 Axon guidance 1/378 233/7206 7.118672201e-05 ko03430 Mismatch repair 7/378 22/7206 8.87658724791e-05 ko00230 Purine metabolism 24/378 194/7206 9.56219094945e-05 ko04022 cGMP-PKG signaling pathway 1/378 216/7206 0.000154803990789 ko05169 Epstein-Barr virus infection 24/378 206/7206 0.000195107817156 ko03460 Fanconi anemia pathway 10/378 51/7206 0.00025876986268 ko04024 cAMP signaling pathway 3/378 279/7206 0.00030875250521 ko04014 Ras signaling pathway 3/378 279/7206 0.00030875250521 ko04062 Chemokine signaling pathway 1/378 201/7206 0.000335028969441 ko03420 Nucleotide excision repair 9/378 46/7206 0.000533764929606 ko03410 Base excision repair 8/378 38/7206 0.000649251822443 ko04218 Cellular senescence 20/378 177/7206 0.000984522040027 ko04015 Rap1 signaling pathway 4/378 278/7206 0.00143091771862 ko04723 Retrograde endocannabinoid signaling 1/378 175/7206 0.00157760695746 ko04510 Focal adhesion 3/378 240/7206 0.00178381692316 ko05168 Herpes simplex infection 20/378 182/7206 0.00185294612625 ko04261 Adrenergic signaling in cardiomyocytes 2/378 205/7206 0.0021329889964 ko04010 MAPK signaling pathway 6/378 321/7206 0.00296758815812 ko04621 NOD-like receptor signaling pathway 1/378 157/7206 0.00329327842593 ko04151 PI3K-Akt signaling pathway 9/378 390/7206 0.00482215675234 ko04623 Cytosolic DNA-sensing pathway 7/378 41/7206 0.00494487512399 ko03440 Homologous recombination 7/378 41/7206 0.00494487512399 ko03060 Protein export 5/378 23/7206 0.00594022467906 ko04728 Dopaminergic synapse 2/378 185/7206 0.00642761510172 ko04921 Oxytocin signaling pathway 3/378 209/7206 0.00694506891058 ko04916 Melanogenesis 1/378 142/7206 0.00697670133696 ko04380 Osteoclast differentiation 1/378 134/7206 0.0101163225001 ko05200 Pathways in cancer 14/378 492/7206 0.0115148849294 ko04140 Autophagy - animal 2/378 164/7206 0.0123295298762 ko04072 Phospholipase D signaling pathway 3/378 197/7206 0.0137327280322 ko05145 Toxoplasmosis 1/378 126/7206 0.0146480089052 ko05166 HTLV-I infection 25/378 292/7206 0.0149590937608 ko04630 Jak-STAT signaling pathway 1/378 132/7206 0.0155106113312 ko05012 Parkinson's disease 2/378 155/7206 0.0174008828604 ko05152 Tuberculosis 3/378 187/7206 0.0187523294984 ko04912 GnRH signaling pathway 1/378 122/7206 0.0216611770677 ko04660 T cell receptor signaling pathway 1/378 124/7206 0.0222642893512 ko04670 Leukocyte transendothelial migration 2/378 151/7206 0.0248226452485 ko04270 Vascular smooth muscle contraction 2/378 154/7206 0.0256279423064 ko04371 Apelin signaling pathway 3/378 177/7206 0.0257358283167 ko03022 Basal transcription factors 6/378 44/7206 0.0261299502827 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/378 182/7206 0.0264380966228 ko04972 Pancreatic secretion 1/378 111/7206 0.0305758243334 ko04070 Phosphatidylinositol signaling system 1/378 112/7206 0.0306801616643 ko04013 MAPK signaling pathway - fly 1/378 115/7206 0.0314867173479 ko05418 Fluid shear stress and atherosclerosis 3/378 173/7206 0.0360032167298 ko04139 Mitophagy - yeast 5/378 37/7206 0.0423497172325 ko04520 Adherens junction 1/378 103/7206 0.0439967488915 ko04659 Th17 cell differentiation 1/378 106/7206 0.0446825653847 ko04390 Hippo signaling pathway 4/378 188/7206 0.0469071764885 ko05231 Choline metabolism in cancer 2/378 134/7206 0.0483145545889 ko04071 Sphingolipid signaling pathway 3/378 162/7206 0.0485432005523 ko04611 Platelet activation 3/378 163/7206 0.048707995905 ko04931 Insulin resistance 2/378 137/7206 0.049398077694