ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1240	423/7206	1.18258064241e-52
ko04724	Glutamatergic synapse	91/1240	152/7206	7.61900251582e-33
ko04713	Circadian entrainment	79/1240	136/7206	2.26244318557e-27
ko05033	Nicotine addiction	46/1240	56/7206	2.07240984606e-26
ko05032	Morphine addiction	68/1240	110/7206	6.12063511223e-26
ko04727	GABAergic synapse	65/1240	110/7206	2.82316397578e-23
ko04728	Dopaminergic synapse	88/1240	185/7206	3.77514265533e-22
ko04725	Cholinergic synapse	80/1240	160/7206	5.8177780475e-22
ko04020	Calcium signaling pathway	109/1240	265/7206	1.03324571829e-20
ko04723	Retrograde endocannabinoid signaling	79/1240	175/7206	2.86928845939e-18
ko04726	Serotonergic synapse	67/1240	137/7206	6.47632643798e-18
ko04024	cAMP signaling pathway	104/1240	279/7206	2.62337782891e-16
ko04721	Synaptic vesicle cycle	46/1240	80/7206	3.54825828715e-16
ko04911	Insulin secretion	57/1240	117/7206	2.5163077333e-15
ko04921	Oxytocin signaling pathway	81/1240	209/7206	5.13898754136e-14
ko04742	Taste transduction	36/1240	61/7206	2.03903867359e-13
ko04970	Salivary secretion	45/1240	95/7206	7.88060264942e-12
ko05031	Amphetamine addiction	43/1240	91/7206	2.5587938702e-11
ko04720	Long-term potentiation	45/1240	99/7206	4.59482410985e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1240	205/7206	3.7184152608e-10
ko04744	Phototransduction	23/1240	36/7206	5.16136433262e-10
ko03010	Ribosome	1/1240	129/7206	9.30505879749e-10
ko03040	Spliceosome	2/1240	145/7206	9.77188819246e-10
ko04022	cGMP-PKG signaling pathway	71/1240	216/7206	1.26157219036e-08
ko04925	Aldosterone synthesis and secretion	42/1240	105/7206	2.48031903005e-08
ko04360	Axon guidance	73/1240	233/7206	7.64644216607e-08
ko04740	Olfactory transduction	34/1240	80/7206	8.63298221802e-08
ko05322	Systemic lupus erythematosus	5/1240	151/7206	1.61495777811e-07
ko03013	RNA transport	7/1240	166/7206	3.82953530511e-07
ko04971	Gastric acid secretion	38/1240	98/7206	4.50178401317e-07
ko04730	Long-term depression	32/1240	78/7206	9.13213820421e-07
ko05030	Cocaine addiction	30/1240	73/7206	1.17911963191e-06
ko04070	Phosphatidylinositol signaling system	40/1240	112/7206	1.83291341106e-06
ko05203	Viral carcinogenesis	21/1240	277/7206	3.07939559948e-06
ko04072	Phospholipase D signaling pathway	60/1240	197/7206	3.29926289636e-06
ko05168	Herpes simplex infection	10/1240	182/7206	3.36212927488e-06
ko04621	NOD-like receptor signaling pathway	8/1240	157/7206	8.25461725185e-06
ko04014	Ras signaling pathway	77/1240	279/7206	1.04703589063e-05
ko04972	Pancreatic secretion	38/1240	111/7206	1.11362255233e-05
ko04745	Phototransduction - fly	18/1240	38/7206	1.60897471783e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1240	74/7206	1.82716865925e-05
ko04514	Cell adhesion molecules (CAMs)	42/1240	130/7206	2.87165099503e-05
ko04060	Cytokine-cytokine receptor interaction	13/1240	191/7206	3.63787501627e-05
ko04010	MAPK signaling pathway	84/1240	321/7206	3.90799851169e-05
ko04540	Gap junction	41/1240	128/7206	4.2533504347e-05
ko04110	Cell cycle	8/1240	145/7206	4.79800799113e-05
ko04141	Protein processing in endoplasmic reticulum	13/1240	184/7206	6.68892936865e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1240	79/7206	7.11639921076e-05
ko04710	Circadian rhythm	18/1240	43/7206	0.000122485107311
ko04750	Inflammatory mediator regulation of TRP channels	38/1240	122/7206	0.000140172772388
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1240	79/7206	0.000234831293477
ko04371	Apelin signaling pathway	50/1240	177/7206	0.000244238782119
ko04976	Bile secretion	27/1240	80/7206	0.000277737984333
ko04120	Ubiquitin mediated proteolysis	9/1240	138/7206	0.00035336804093
ko04930	Type II diabetes mellitus	20/1240	54/7206	0.000416514627821
ko04924	Renin secretion	28/1240	86/7206	0.000453516970181
ko05164	Influenza A	13/1240	167/7206	0.000561509708934
ko04915	Estrogen signaling pathway	38/1240	131/7206	0.000651288541432
ko04270	Vascular smooth muscle contraction	43/1240	154/7206	0.000756618276999
ko04064	NF-kappa B signaling pathway	5/1240	96/7206	0.000895449984021
ko05169	Epstein-Barr virus infection	19/1240	206/7206	0.00136774239576
ko05414	Dilated cardiomyopathy	33/1240	112/7206	0.00139156369942
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1240	59/7206	0.00157804012585
ko04964	Proximal tubule bicarbonate reclamation	12/1240	29/7206	0.00186729112829
ko04922	Glucagon signaling pathway	36/1240	128/7206	0.00193040658873
ko04217	Necroptosis	16/1240	178/7206	0.00239883889629
ko04260	Cardiac muscle contraction	29/1240	98/7206	0.00265179406697
ko04960	Aldosterone-regulated sodium reabsorption	15/1240	41/7206	0.00273131126477
ko03420	Nucleotide excision repair	1/1240	46/7206	0.00279983478925
ko05140	Leishmaniasis	4/1240	75/7206	0.00327141890363
ko04612	Antigen processing and presentation	4/1240	77/7206	0.003382164445
ko05161	Hepatitis B	16/1240	173/7206	0.00407275039279
ko03022	Basal transcription factors	1/1240	44/7206	0.00424154651849
ko00071	Fatty acid degradation	1/1240	45/7206	0.00441279320209
ko04622	RIG-I-like receptor signaling pathway	3/1240	62/7206	0.00621350259532
ko04626	Plant-pathogen interaction	8/1240	18/7206	0.00645699449204
ko04146	Peroxisome	6/1240	89/7206	0.00665334029158
ko04610	Complement and coagulation cascades	5/1240	79/7206	0.00666330026976
ko05162	Measles	10/1240	120/7206	0.00704685361874
ko05231	Choline metabolism in cancer	35/1240	134/7206	0.00781040428912
ko04966	Collecting duct acid secretion	10/1240	26/7206	0.00815347837325
ko05166	HTLV-I infection	34/1240	292/7206	0.00889235133204
ko00240	Pyrimidine metabolism	9/1240	110/7206	0.0102860622713
ko04912	GnRH signaling pathway	32/1240	122/7206	0.0107569441635
ko05110	Vibrio cholerae infection	19/1240	63/7206	0.0108138674653
ko04973	Carbohydrate digestion and absorption	14/1240	42/7206	0.0117016884294
ko04015	Rap1 signaling pathway	64/1240	278/7206	0.0117598274928
ko03018	RNA degradation	6/1240	84/7206	0.0125512451263
ko04923	Regulation of lipolysis in adipocytes	22/1240	77/7206	0.0139638399101
ko04711	Circadian rhythm - fly	6/1240	13/7206	0.0146977426701
ko03410	Base excision repair	1/1240	38/7206	0.0151815562263
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1240	100/7206	0.0153758619671
ko05222	Small cell lung cancer	7/1240	89/7206	0.0158439908188
ko05144	Malaria	2/1240	45/7206	0.0170276609131
ko04214	Apoptosis - fly	5/1240	72/7206	0.0177759982739
ko00310	Lysine degradation	5/1240	73/7206	0.0181067639538
ko00280	Valine, leucine and isoleucine degradation	3/1240	54/7206	0.0181080372105
ko05321	Inflammatory bowel disease (IBD)	3/1240	56/7206	0.018946612322
ko04657	IL-17 signaling pathway	7/1240	87/7206	0.0214004458925
ko05133	Pertussis	7/1240	87/7206	0.0214004458925
ko00860	Porphyrin and chlorophyll metabolism	1/1240	34/7206	0.0215443687464
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1240	14/7206	0.0220435991564
ko05145	Toxoplasmosis	12/1240	126/7206	0.0228243704793
ko04916	Melanogenesis	35/1240	142/7206	0.0240154803013
ko00590	Arachidonic acid metabolism	3/1240	52/7206	0.025753794723
ko04630	Jak-STAT signaling pathway	13/1240	132/7206	0.0261585036838
ko04330	Notch signaling pathway	4/1240	62/7206	0.0261634373159
ko05205	Proteoglycans in cancer	33/1240	271/7206	0.0264189599559
ko05016	Huntington's disease	25/1240	215/7206	0.0274226129269
ko04142	Lysosome	16/1240	151/7206	0.0289465993837
ko04918	Thyroid hormone synthesis	23/1240	86/7206	0.0296238441488
ko05214	Glioma	21/1240	79/7206	0.0347099067583
ko05131	Shigellosis	7/1240	82/7206	0.038264762624
ko04658	Th1 and Th2 cell differentiation	9/1240	96/7206	0.0406731216811
ko04115	p53 signaling pathway	6/1240	74/7206	0.0424465553533
ko04213	Longevity regulating pathway - multiple species	22/1240	86/7206	0.0440755717602
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1240	182/7206	0.0459344383671
ko05340	Primary immunodeficiency	1/1240	30/7206	0.0488740507799