ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	159/891	423/7206	2.4199037909e-43
ko05033	Nicotine addiction	49/891	56/7206	9.92993816505e-38
ko04724	Glutamatergic synapse	80/891	152/7206	5.11096636739e-34
ko05032	Morphine addiction	59/891	110/7206	7.20850139426e-26
ko04727	GABAergic synapse	58/891	110/7206	6.18017017587e-25
ko04728	Dopaminergic synapse	75/891	185/7206	8.85544845979e-23
ko04713	Circadian entrainment	62/891	136/7206	3.3064587251e-22
ko04725	Cholinergic synapse	67/891	160/7206	2.24414161651e-21
ko04723	Retrograde endocannabinoid signaling	69/891	175/7206	3.20415300895e-20
ko04024	cAMP signaling pathway	89/891	279/7206	1.48581197074e-18
ko04721	Synaptic vesicle cycle	41/891	80/7206	2.27430652793e-17
ko04911	Insulin secretion	47/891	117/7206	1.70008361023e-14
ko04744	Phototransduction	24/891	36/7206	3.5417100123e-14
ko05031	Amphetamine addiction	39/891	91/7206	2.52787094847e-13
ko04742	Taste transduction	31/891	61/7206	2.60176808306e-13
ko04020	Calcium signaling pathway	76/891	265/7206	3.38350657112e-13
ko04726	Serotonergic synapse	49/891	137/7206	8.99061650782e-13
ko04921	Oxytocin signaling pathway	64/891	209/7206	1.74061347813e-12
ko04720	Long-term potentiation	39/891	99/7206	6.2997828299e-12
ko04261	Adrenergic signaling in cardiomyocytes	61/891	205/7206	1.56217908758e-11
ko05030	Cocaine addiction	30/891	73/7206	5.23533236147e-10
ko05014	Amyotrophic lateral sclerosis (ALS)	27/891	74/7206	7.81561786592e-08
ko03040	Spliceosome	1/891	145/7206	1.42309908896e-07
ko04925	Aldosterone synthesis and secretion	33/891	105/7206	1.83364566045e-07
ko04060	Cytokine-cytokine receptor interaction	4/891	191/7206	5.08804926011e-07
ko04010	MAPK signaling pathway	71/891	321/7206	5.50150614576e-07
ko04971	Gastric acid secretion	30/891	98/7206	1.23838303278e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/891	79/7206	1.37883799275e-06
ko04514	Cell adhesion molecules (CAMs)	35/891	130/7206	5.16360671144e-06
ko05203	Viral carcinogenesis	12/891	277/7206	6.03081063351e-06
ko04260	Cardiac muscle contraction	29/891	98/7206	6.17961762265e-06
ko04360	Axon guidance	53/891	233/7206	6.55640663549e-06
ko04970	Salivary secretion	28/891	95/7206	9.63262138537e-06
ko04740	Olfactory transduction	24/891	80/7206	2.08239276402e-05
ko05168	Herpes simplex infection	6/891	182/7206	2.98803570109e-05
ko03013	RNA transport	5/891	166/7206	3.65758290515e-05
ko04072	Phospholipase D signaling pathway	45/891	197/7206	3.68365022771e-05
ko05164	Influenza A	5/891	167/7206	3.77423194073e-05
ko05322	Systemic lupus erythematosus	4/891	151/7206	4.476011535e-05
ko04972	Pancreatic secretion	29/891	111/7206	6.09376818814e-05
ko04745	Phototransduction - fly	14/891	38/7206	9.66904882666e-05
ko04022	cGMP-PKG signaling pathway	46/891	216/7206	0.00020113447745
ko04070	Phosphatidylinositol signaling system	28/891	112/7206	0.000215325520331
ko04350	TGF-beta signaling pathway	2/891	103/7206	0.000230716655976
ko04141	Protein processing in endoplasmic reticulum	8/891	184/7206	0.000254500064616
ko04621	NOD-like receptor signaling pathway	6/891	157/7206	0.000322661915576
ko04120	Ubiquitin mediated proteolysis	5/891	138/7206	0.000587199700845
ko04966	Collecting duct acid secretion	10/891	26/7206	0.000652307813922
ko05414	Dilated cardiomyopathy	27/891	112/7206	0.00068271247481
ko04612	Antigen processing and presentation	1/891	77/7206	0.000737226301411
ko03008	Ribosome biogenesis in eukaryotes	1/891	79/7206	0.000782110372506
ko05169	Epstein-Barr virus infection	11/891	206/7206	0.00114380119037
ko04110	Cell cycle	6/891	145/7206	0.00124218027925
ko04730	Long-term depression	20/891	78/7206	0.00136779098358
ko04915	Estrogen signaling pathway	28/891	131/7206	0.00299898958231
ko05410	Hypertrophic cardiomyopathy (HCM)	23/891	100/7206	0.00308083343184
ko05162	Measles	5/891	120/7206	0.00311318070978
ko04630	Jak-STAT signaling pathway	6/891	132/7206	0.00316759394581
ko05034	Alcoholism	45/891	238/7206	0.00345493045662
ko04640	Hematopoietic cell lineage	1/891	64/7206	0.00360348107565
ko04014	Ras signaling pathway	51/891	279/7206	0.00383287575523
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/891	14/7206	0.00437450985578
ko05205	Proteoglycans in cancer	19/891	271/7206	0.00465587427977
ko04750	Inflammatory mediator regulation of TRP channels	26/891	122/7206	0.00498594399499
ko04930	Type II diabetes mellitus	14/891	54/7206	0.00566259531063
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/891	182/7206	0.00603880560909
ko04964	Proximal tubule bicarbonate reclamation	9/891	29/7206	0.00649950539828
ko05161	Hepatitis B	10/891	173/7206	0.00669002223725
ko05140	Leishmaniasis	2/891	75/7206	0.00702773491007
ko00240	Pyrimidine metabolism	5/891	110/7206	0.00819581659397
ko04976	Bile secretion	18/891	80/7206	0.00962691805683
ko04214	Apoptosis - fly	2/891	72/7206	0.0102404287917
ko05110	Vibrio cholerae infection	15/891	63/7206	0.010834038393
ko03018	RNA degradation	3/891	84/7206	0.0111261132483
ko04140	Autophagy - animal	10/891	164/7206	0.0112889232851
ko04064	NF-kappa B signaling pathway	4/891	96/7206	0.0114556754093
ko00480	Glutathione metabolism	1/891	55/7206	0.0118552085751
ko04924	Renin secretion	19/891	86/7206	0.0119839564121
ko05016	Huntington's disease	15/891	215/7206	0.0149739722578
ko04626	Plant-pathogen interaction	6/891	18/7206	0.0175245843461
ko05166	HTLV-I infection	23/891	292/7206	0.0178476098746
ko05215	Prostate cancer	6/891	111/7206	0.0199322295684
ko04540	Gap junction	25/891	128/7206	0.0201398870601
ko04657	IL-17 signaling pathway	4/891	87/7206	0.0214808657563
ko04146	Peroxisome	4/891	89/7206	0.0218166002838
ko04550	Signaling pathways regulating pluripotency of stem cells	11/891	165/7206	0.0225106639642
ko00260	Glycine, serine and threonine metabolism	1/891	48/7206	0.0255145224964
ko05219	Bladder cancer	1/891	48/7206	0.0255145224964
ko00330	Arginine and proline metabolism	2/891	61/7206	0.0292996130649
ko04330	Notch signaling pathway	2/891	62/7206	0.0301116040706
ko04973	Carbohydrate digestion and absorption	10/891	42/7206	0.0327547656213
ko00562	Inositol phosphate metabolism	18/891	89/7206	0.0333400799037
ko03022	Basal transcription factors	1/891	44/7206	0.0371654068336
ko00071	Fatty acid degradation	1/891	45/7206	0.0377185995091
ko03420	Nucleotide excision repair	1/891	46/7206	0.0388739198986
ko04137	Mitophagy - animal	4/891	82/7206	0.0409110225013
ko05321	Inflammatory bowel disease (IBD)	2/891	56/7206	0.0409712177102
ko03320	PPAR signaling pathway	3/891	69/7206	0.0417095580513
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/891	59/7206	0.0433513804781
ko04371	Apelin signaling pathway	31/891	177/7206	0.0481851610245