ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 43/413 145/7206 3.23516218676e-20 ko03440 Homologous recombination 24/413 41/7206 5.07194321307e-20 ko03030 DNA replication 21/413 38/7206 5.9655888057e-17 ko04111 Cell cycle - yeast 31/413 90/7206 6.12882189704e-17 ko03460 Fanconi anemia pathway 23/413 51/7206 6.73059552922e-16 ko03008 Ribosome biogenesis in eukaryotes 28/413 79/7206 8.79921675599e-16 ko03040 Spliceosome 37/413 145/7206 3.52532513334e-15 ko04113 Meiosis - yeast 22/413 70/7206 1.84911862236e-11 ko03013 RNA transport 34/413 166/7206 4.03145822541e-11 ko00240 Pyrimidine metabolism 27/413 110/7206 5.76762794026e-11 ko03410 Base excision repair 16/413 38/7206 7.06558653912e-11 ko03430 Mismatch repair 10/413 22/7206 1.19244656688e-07 ko03420 Nucleotide excision repair 14/413 46/7206 1.46872900991e-07 ko04144 Endocytosis 3/413 342/7206 3.76624968346e-06 ko04151 PI3K-Akt signaling pathway 5/413 390/7206 9.13906292211e-06 ko05322 Systemic lupus erythematosus 23/413 151/7206 1.40565437269e-05 ko03018 RNA degradation 15/413 84/7206 7.06245834765e-05 ko04261 Adrenergic signaling in cardiomyocytes 1/413 205/7206 0.000103023441892 ko04024 cAMP signaling pathway 3/413 279/7206 0.000104983108615 ko03450 Non-homologous end-joining 6/413 15/7206 0.000109810113291 ko04114 Oocyte meiosis 20/413 139/7206 0.000115765058451 ko03020 RNA polymerase 8/413 29/7206 0.000160545379888 ko04060 Cytokine-cytokine receptor interaction 1/413 191/7206 0.000223768128022 ko04728 Dopaminergic synapse 1/413 185/7206 0.000328845836921 ko05152 Tuberculosis 1/413 187/7206 0.000332488943222 ko03022 Basal transcription factors 9/413 44/7206 0.000720031373349 ko04723 Retrograde endocannabinoid signaling 1/413 175/7206 0.00073479637093 ko05166 HTLV-I infection 31/413 292/7206 0.000734946259492 ko04530 Tight junction 3/413 228/7206 0.00125032748509 ko04015 Rap1 signaling pathway 5/413 278/7206 0.00216064435205 ko04142 Lysosome 1/413 151/7206 0.00222560407462 ko04724 Glutamatergic synapse 1/413 152/7206 0.00223872267151 ko04270 Vascular smooth muscle contraction 1/413 154/7206 0.00229263434468 ko05012 Parkinson's disease 1/413 155/7206 0.00233373706129 ko04022 cGMP-PKG signaling pathway 3/413 216/7206 0.0025350601694 ko04510 Focal adhesion 4/413 240/7206 0.00275319104027 ko04010 MAPK signaling pathway 7/413 321/7206 0.00293507656059 ko04218 Cellular senescence 20/413 177/7206 0.00297242447989 ko05205 Proteoglycans in cancer 5/413 271/7206 0.00298225462686 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/413 182/7206 0.00305753686841 ko04713 Circadian entrainment 1/413 136/7206 0.00472416818872 ko04014 Ras signaling pathway 6/413 279/7206 0.00543339374635 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/413 135/7206 0.00732943994793 ko04914 Progesterone-mediated oocyte maturation 13/413 104/7206 0.00826592010755 ko04725 Cholinergic synapse 2/413 160/7206 0.00875119085312 ko04115 p53 signaling pathway 10/413 74/7206 0.00913356269652 ko05145 Toxoplasmosis 1/413 126/7206 0.010263308431 ko00190 Oxidative phosphorylation 1/413 127/7206 0.0104261542581 ko00230 Purine metabolism 20/413 194/7206 0.0109447378291 ko05203 Viral carcinogenesis 26/413 277/7206 0.0117017661205 ko04371 Apelin signaling pathway 3/413 177/7206 0.0133390533562 ko04921 Oxytocin signaling pathway 4/413 209/7206 0.0143139735804 ko04911 Insulin secretion 1/413 117/7206 0.0145697474287 ko05034 Alcoholism 23/413 238/7206 0.0146870378857 ko05418 Fluid shear stress and atherosclerosis 3/413 173/7206 0.018834889356 ko03015 mRNA surveillance pathway 11/413 93/7206 0.0207810301244 ko04727 GABAergic synapse 1/413 110/7206 0.0210859471007 ko05032 Morphine addiction 1/413 110/7206 0.0210859471007 ko04972 Pancreatic secretion 1/413 111/7206 0.0212646279149 ko04726 Serotonergic synapse 2/413 137/7206 0.0243851766134 ko05016 Huntington's disease 5/413 215/7206 0.0247292623491 ko04071 Sphingolipid signaling pathway 3/413 162/7206 0.0255169685505 ko04145 Phagosome 3/413 162/7206 0.0255169685505 ko04611 Platelet activation 3/413 163/7206 0.0255705399906 ko05167 Kaposi's sarcoma-associated herpesvirus infection 4/413 191/7206 0.0257363385476 ko04810 Regulation of actin cytoskeleton 7/413 264/7206 0.0294724454644 ko04659 Th17 cell differentiation 1/413 106/7206 0.0315155833237 ko01200 Carbon metabolism 2/413 128/7206 0.0340644887736 ko04922 Glucagon signaling pathway 2/413 128/7206 0.0340644887736 ko04540 Gap junction 2/413 128/7206 0.0340644887736 ko05142 Chagas disease (American trypanosomiasis) 2/413 130/7206 0.0342758759882 ko04915 Estrogen signaling pathway 2/413 131/7206 0.03450856473 ko04722 Neurotrophin signaling pathway 3/413 160/7206 0.0363193920332 ko04120 Ubiquitin mediated proteolysis 14/413 138/7206 0.0385055397759 ko04974 Protein digestion and absorption 1/413 96/7206 0.0439044961529 ko04658 Th1 and Th2 cell differentiation 1/413 96/7206 0.0439044961529 ko04064 NF-kappa B signaling pathway 1/413 96/7206 0.0439044961529 ko04062 Chemokine signaling pathway 5/413 201/7206 0.0441687511365 ko04650 Natural killer cell mediated cytotoxicity 1/413 97/7206 0.0442675758257 ko04971 Gastric acid secretion 1/413 98/7206 0.0447635876256 ko00564 Glycerophospholipid metabolism 1/413 99/7206 0.0453921075557 ko04912 GnRH signaling pathway 2/413 122/7206 0.0477900285534 ko04066 HIF-1 signaling pathway 2/413 123/7206 0.0480161754747 ko04660 T cell receptor signaling pathway 2/413 124/7206 0.0483533370795 ko04670 Leukocyte transendothelial migration 3/413 151/7206 0.0489087646192 ko05160 Hepatitis C 3/413 153/7206 0.0498723855393