ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1177	423/7206	3.34198036453e-58
ko04724	Glutamatergic synapse	87/1177	152/7206	3.75751223771e-31
ko05033	Nicotine addiction	47/1177	56/7206	7.92449671738e-29
ko04713	Circadian entrainment	74/1177	136/7206	9.67816861236e-25
ko05032	Morphine addiction	65/1177	110/7206	1.38089694037e-24
ko04727	GABAergic synapse	64/1177	110/7206	1.05499920142e-23
ko04721	Synaptic vesicle cycle	51/1177	80/7206	1.17743225693e-21
ko04728	Dopaminergic synapse	83/1177	185/7206	2.02758295186e-20
ko04725	Cholinergic synapse	75/1177	160/7206	6.23615641262e-20
ko04020	Calcium signaling pathway	103/1177	265/7206	2.77152104857e-19
ko04024	cAMP signaling pathway	104/1177	279/7206	7.72475965491e-18
ko04723	Retrograde endocannabinoid signaling	75/1177	175/7206	3.66103808915e-17
ko04742	Taste transduction	38/1177	61/7206	5.90862947278e-16
ko04726	Serotonergic synapse	61/1177	137/7206	4.1216473902e-15
ko04921	Oxytocin signaling pathway	78/1177	209/7206	1.17405111158e-13
ko04744	Phototransduction	26/1177	36/7206	1.30726528163e-13
ko04911	Insulin secretion	52/1177	117/7206	5.00143515195e-13
ko04970	Salivary secretion	44/1177	95/7206	5.6624696844e-12
ko04720	Long-term potentiation	45/1177	99/7206	7.30307344966e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1177	205/7206	8.8041532357e-12
ko03040	Spliceosome	1/1177	145/7206	1.95321084154e-10
ko05031	Amphetamine addiction	40/1177	91/7206	3.82125099311e-10
ko05203	Viral carcinogenesis	14/1177	277/7206	6.73268325692e-09
ko05168	Herpes simplex infection	6/1177	182/7206	3.6135301866e-08
ko04360	Axon guidance	71/1177	233/7206	4.18232795649e-08
ko04060	Cytokine-cytokine receptor interaction	7/1177	191/7206	4.57595674139e-08
ko05164	Influenza A	5/1177	167/7206	5.77701067534e-08
ko04740	Olfactory transduction	33/1177	80/7206	8.7518327565e-08
ko04925	Aldosterone synthesis and secretion	39/1177	105/7206	1.82965687075e-07
ko04022	cGMP-PKG signaling pathway	65/1177	216/7206	2.95746513496e-07
ko05030	Cocaine addiction	30/1177	73/7206	3.72200701245e-07
ko05322	Systemic lupus erythematosus	5/1177	151/7206	5.81162516388e-07
ko04120	Ubiquitin mediated proteolysis	4/1177	138/7206	6.34383280845e-07
ko04971	Gastric acid secretion	36/1177	98/7206	1.17788248412e-06
ko04540	Gap junction	43/1177	128/7206	1.36087686367e-06
ko04966	Collecting duct acid secretion	15/1177	26/7206	1.85975839449e-06
ko03013	RNA transport	7/1177	166/7206	1.90723768401e-06
ko04924	Renin secretion	32/1177	86/7206	2.33392787411e-06
ko04010	MAPK signaling pathway	83/1177	321/7206	9.03848208498e-06
ko04514	Cell adhesion molecules (CAMs)	41/1177	130/7206	1.87268399946e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1177	74/7206	2.17690388903e-05
ko04621	NOD-like receptor signaling pathway	8/1177	157/7206	2.53924515192e-05
ko04070	Phosphatidylinositol signaling system	36/1177	112/7206	2.76932907971e-05
ko04730	Long-term depression	28/1177	78/7206	3.3850118725e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1177	79/7206	3.79755791403e-05
ko05169	Epstein-Barr virus infection	14/1177	206/7206	5.13178691301e-05
ko04014	Ras signaling pathway	71/1177	279/7206	6.70418347501e-05
ko04972	Pancreatic secretion	35/1177	111/7206	7.3009308326e-05
ko04260	Cardiac muscle contraction	32/1177	98/7206	7.89406818865e-05
ko04110	Cell cycle	8/1177	145/7206	9.81031293854e-05
ko04141	Protein processing in endoplasmic reticulum	12/1177	184/7206	0.000103069687294
ko04745	Phototransduction - fly	16/1177	38/7206	0.00014274588145
ko04626	Plant-pathogen interaction	10/1177	18/7206	0.000160953135661
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko05414	Dilated cardiomyopathy	34/1177	112/7206	0.00023897088685
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1177	59/7206	0.000271716139479
ko04976	Bile secretion	26/1177	80/7206	0.000341310256923
ko05140	Leishmaniasis	2/1177	75/7206	0.000395931088136
ko04064	NF-kappa B signaling pathway	4/1177	96/7206	0.00040627303734
ko05110	Vibrio cholerae infection	22/1177	63/7206	0.00040996559551
ko04750	Inflammatory mediator regulation of TRP channels	35/1177	122/7206	0.00048603702598
ko05162	Measles	7/1177	120/7206	0.000703298764986
ko05205	Proteoglycans in cancer	25/1177	271/7206	0.000767840884157
ko05161	Hepatitis B	13/1177	173/7206	0.000795741881933
ko04610	Complement and coagulation cascades	3/1177	79/7206	0.00105585209928
ko04072	Phospholipase D signaling pathway	50/1177	197/7206	0.00115255452755
ko04964	Proximal tubule bicarbonate reclamation	12/1177	29/7206	0.00116709670258
ko04146	Peroxisome	4/1177	89/7206	0.00123489807589
ko04612	Antigen processing and presentation	3/1177	77/7206	0.00156899208048
ko04371	Apelin signaling pathway	45/1177	177/7206	0.00185453225107
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1177	182/7206	0.00214046186947
ko04915	Estrogen signaling pathway	35/1177	131/7206	0.00258321057853
ko05166	HTLV-I infection	30/1177	292/7206	0.00350453051171
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1177	14/7206	0.00361649239703
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko00480	Glutathione metabolism	2/1177	55/7206	0.0056995074721
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1177	100/7206	0.00605082405785
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko03018	RNA degradation	5/1177	84/7206	0.00696508148862
ko05144	Malaria	1/1177	45/7206	0.0069846573587
ko00071	Fatty acid degradation	1/1177	45/7206	0.0069846573587
ko05145	Toxoplasmosis	10/1177	126/7206	0.00732677142623
ko04923	Regulation of lipolysis in adipocytes	22/1177	77/7206	0.00747431365328
ko00240	Pyrimidine metabolism	8/1177	110/7206	0.00867748356579
ko05418	Fluid shear stress and atherosclerosis	16/1177	173/7206	0.00899814797265
ko04330	Notch signaling pathway	3/1177	62/7206	0.00923454903633
ko04622	RIG-I-like receptor signaling pathway	3/1177	62/7206	0.00923454903633
ko04640	Hematopoietic cell lineage	3/1177	64/7206	0.0095996163958
ko04214	Apoptosis - fly	4/1177	72/7206	0.00964489161724
ko05131	Shigellosis	5/1177	82/7206	0.00978146702001
ko00310	Lysine degradation	4/1177	73/7206	0.00985629864885
ko04630	Jak-STAT signaling pathway	11/1177	132/7206	0.0119325471535
ko04658	Th1 and Th2 cell differentiation	7/1177	96/7206	0.0121417357921
ko04657	IL-17 signaling pathway	6/1177	87/7206	0.0128114994415
ko05133	Pertussis	6/1177	87/7206	0.0128114994415
ko00630	Glyoxylate and dicarboxylate metabolism	1/1177	38/7206	0.0148791725044
ko04668	TNF signaling pathway	10/1177	120/7206	0.0171521122607
ko04912	GnRH signaling pathway	30/1177	122/7206	0.0182150411488
ko01524	Platinum drug resistance	5/1177	76/7206	0.0183774233322
ko04620	Toll-like receptor signaling pathway	8/1177	100/7206	0.0202214296738
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko00280	Valine, leucine and isoleucine degradation	3/1177	54/7206	0.0264623290671
ko04916	Melanogenesis	33/1177	142/7206	0.0291211125648
ko04978	Mineral absorption	12/1177	40/7206	0.029209410736
ko05222	Small cell lung cancer	7/1177	89/7206	0.0294733180324
ko04015	Rap1 signaling pathway	59/1177	278/7206	0.0310236641095
ko04350	TGF-beta signaling pathway	9/1177	103/7206	0.0319722681154
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1177	92/7206	0.0320452617749
ko00500	Starch and sucrose metabolism	1/1177	35/7206	0.0349760506126
ko04270	Vascular smooth muscle contraction	35/1177	154/7206	0.0358355241696
ko00330	Arginine and proline metabolism	4/1177	61/7206	0.0361817444402
ko05206	MicroRNAs in cancer	19/1177	177/7206	0.0395910506611
ko04217	Necroptosis	19/1177	178/7206	0.0396231169613
ko00562	Inositol phosphate metabolism	22/1177	89/7206	0.041920547259
ko05340	Primary immunodeficiency	1/1177	30/7206	0.049342851322