ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/282 134/7206 1.95598525353e-14 ko04060 Cytokine-cytokine receptor interaction 34/282 191/7206 4.55800012054e-14 ko04621 NOD-like receptor signaling pathway 30/282 157/7206 2.27185300916e-13 ko04064 NF-kappa B signaling pathway 23/282 96/7206 1.14694407271e-12 ko05164 Influenza A 28/282 167/7206 4.08212056693e-11 ko04668 TNF signaling pathway 23/282 120/7206 1.53896314746e-10 ko04620 Toll-like receptor signaling pathway 19/282 100/7206 7.49711312295e-09 ko05145 Toxoplasmosis 21/282 126/7206 1.39358829344e-08 ko05140 Leishmaniasis 16/282 75/7206 2.10775198205e-08 ko05162 Measles 20/282 120/7206 3.12061586524e-08 ko05168 Herpes simplex infection 25/282 182/7206 3.27552332606e-08 ko04622 RIG-I-like receptor signaling pathway 14/282 62/7206 7.67762995896e-08 ko04657 IL-17 signaling pathway 16/282 87/7206 1.90915044608e-07 ko05161 Hepatitis B 23/282 173/7206 2.18855622805e-07 ko05152 Tuberculosis 24/282 187/7206 2.31458106454e-07 ko05133 Pertussis 15/282 87/7206 1.10569412697e-06 ko05321 Inflammatory bowel disease (IBD) 12/282 56/7206 1.21968110628e-06 ko04217 Necroptosis 22/282 178/7206 1.44169261151e-06 ko04660 T cell receptor signaling pathway 17/282 124/7206 5.74465244236e-06 ko05160 Hepatitis C 19/282 153/7206 7.15649086958e-06 ko05323 Rheumatoid arthritis 14/282 89/7206 7.77448115812e-06 ko04623 Cytosolic DNA-sensing pathway 9/282 41/7206 2.20212700112e-05 ko05144 Malaria 9/282 45/7206 4.85367017126e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/282 191/7206 5.22674282311e-05 ko05150 Staphylococcus aureus infection 8/282 36/7206 5.79228334799e-05 ko04672 Intestinal immune network for IgA production 8/282 37/7206 7.14256116613e-05 ko05131 Shigellosis 12/282 82/7206 7.28090232378e-05 ko04658 Th1 and Th2 cell differentiation 13/282 96/7206 8.36166566967e-05 ko05132 Salmonella infection 13/282 98/7206 0.000103788121003 ko05340 Primary immunodeficiency 7/282 30/7206 0.000122300889184 ko05134 Legionellosis 11/282 74/7206 0.000125905784847 ko05142 Chagas disease (American trypanosomiasis) 15/282 130/7206 0.000155788071238 ko04630 Jak-STAT signaling pathway 15/282 132/7206 0.000184993851084 ko04210 Apoptosis 18/282 180/7206 0.000222987533745 ko04933 AGE-RAGE signaling pathway in diabetic complications 15/282 135/7206 0.000237674580306 ko04062 Chemokine signaling pathway 19/282 201/7206 0.000310832776229 ko04659 Th17 cell differentiation 12/282 106/7206 0.000837755484885 ko04610 Complement and coagulation cascades 10/282 79/7206 0.000947404816311 ko04650 Natural killer cell mediated cytotoxicity 11/282 97/7206 0.00134996664109 ko05146 Amoebiasis 11/282 99/7206 0.00159651130718 ko04662 B cell receptor signaling pathway 10/282 88/7206 0.00217895029861 ko04080 Neuroactive ligand-receptor interaction 6/282 423/7206 0.0040537590955 ko05332 Graft-versus-host disease 4/282 18/7206 0.00454866831085 ko04940 Type I diabetes mellitus 5/282 32/7206 0.00748747280679 ko05143 African trypanosomiasis 5/282 32/7206 0.00748747280679 ko04666 Fc gamma R-mediated phagocytosis 11/282 122/7206 0.00805266678449 ko04670 Leukocyte transendothelial migration 13/282 151/7206 0.0083499698531 ko00643 Styrene degradation 2/282 4/7206 0.00868985371542 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/282 92/7206 0.00958067799022 ko04612 Antigen processing and presentation 8/282 77/7206 0.01008738613 ko04728 Dopaminergic synapse 1/282 185/7206 0.0107296690436 ko05166 HTLV-I infection 20/282 292/7206 0.0130003139821 ko05330 Allograft rejection 4/282 24/7206 0.0131390795763 ko05016 Huntington's disease 2/282 215/7206 0.0182593767401 ko04917 Prolactin signaling pathway 8/282 87/7206 0.0200745686664 ko00140 Steroid hormone biosynthesis 5/282 41/7206 0.0209627695142 ko04931 Insulin resistance 11/282 137/7206 0.0221833644209 ko04550 Signaling pathways regulating pluripotency of stem cells 1/282 165/7206 0.0224962724122 ko04920 Adipocytokine signaling pathway 8/282 89/7206 0.0227042546155 ko00051 Fructose and mannose metabolism 5/282 42/7206 0.0230590023405 ko04115 p53 signaling pathway 7/282 74/7206 0.0250911842285 ko05320 Autoimmune thyroid disease 4/282 29/7206 0.025221454372 ko05034 Alcoholism 3/282 238/7206 0.0261479233745 ko05310 Asthma 3/282 17/7206 0.0268391597572 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/282 182/7206 0.0314321789892 ko04512 ECM-receptor interaction 7/282 79/7206 0.0343301947228 ko04390 Hippo signaling pathway 2/282 188/7206 0.0350251005651 ko04215 Apoptosis - multiple species 5/282 47/7206 0.0355507353754 ko04514 Cell adhesion molecules (CAMs) 10/282 130/7206 0.0361272264838 ko04640 Hematopoietic cell lineage 6/282 64/7206 0.0382887647924 ko00120 Primary bile acid biosynthesis 3/282 20/7206 0.0412966238658 ko04624 Toll and Imd signaling pathway 5/282 49/7206 0.041520479267 ko04114 Oocyte meiosis 1/282 139/7206 0.0450075452204 ko04916 Melanogenesis 1/282 142/7206 0.0455985886797 ko05418 Fluid shear stress and atherosclerosis 12/282 173/7206 0.0459882715431