ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1031	423/7206	9.50506756661e-47
ko05033	Nicotine addiction	49/1031	56/7206	1.30793436649e-34
ko04724	Glutamatergic synapse	85/1031	152/7206	7.6827816489e-34
ko05032	Morphine addiction	64/1031	110/7206	5.04138226455e-27
ko04727	GABAergic synapse	62/1031	110/7206	3.64367291316e-25
ko04713	Circadian entrainment	70/1031	136/7206	4.42088120859e-25
ko04728	Dopaminergic synapse	82/1031	185/7206	1.29010681933e-23
ko04725	Cholinergic synapse	73/1031	160/7206	4.82918638636e-22
ko04721	Synaptic vesicle cycle	48/1031	80/7206	2.41611021618e-21
ko04723	Retrograde endocannabinoid signaling	75/1031	175/7206	1.33316178776e-20
ko04024	cAMP signaling pathway	97/1031	279/7206	1.58627984558e-18
ko04742	Taste transduction	36/1031	61/7206	5.48340403068e-16
ko04911	Insulin secretion	50/1031	117/7206	4.69521901039e-14
ko04726	Serotonergic synapse	55/1031	137/7206	6.09759642621e-14
ko04020	Calcium signaling pathway	82/1031	265/7206	1.42576702341e-12
ko05031	Amphetamine addiction	40/1031	91/7206	5.66036985823e-12
ko04720	Long-term potentiation	42/1031	99/7206	6.96506370347e-12
ko04921	Oxytocin signaling pathway	67/1031	209/7206	3.18610622837e-11
ko04261	Adrenergic signaling in cardiomyocytes	66/1031	205/7206	3.90962743942e-11
ko04360	Axon guidance	68/1031	233/7206	2.73886585381e-09
ko05030	Cocaine addiction	31/1031	73/7206	3.95364718778e-09
ko03040	Spliceosome	1/1031	145/7206	5.70638185375e-09
ko04744	Phototransduction	20/1031	36/7206	8.09687233531e-09
ko04970	Salivary secretion	36/1031	95/7206	9.01071198087e-09
ko04740	Olfactory transduction	31/1031	80/7206	5.31192979088e-08
ko05168	Herpes simplex infection	5/1031	182/7206	2.5003209233e-07
ko04925	Aldosterone synthesis and secretion	36/1031	105/7206	2.5961432904e-07
ko04971	Gastric acid secretion	34/1031	98/7206	2.85426417578e-07
ko04060	Cytokine-cytokine receptor interaction	6/1031	191/7206	3.14114180417e-07
ko05203	Viral carcinogenesis	14/1031	277/7206	7.29644004174e-07
ko04010	MAPK signaling pathway	78/1031	321/7206	1.15003311045e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1031	74/7206	1.5589566346e-06
ko03013	RNA transport	5/1031	166/7206	1.5928784182e-06
ko04621	NOD-like receptor signaling pathway	5/1031	157/7206	4.86252478282e-06
ko05322	Systemic lupus erythematosus	5/1031	151/7206	1.01671539285e-05
ko04514	Cell adhesion molecules (CAMs)	38/1031	130/7206	1.04109633126e-05
ko04022	cGMP-PKG signaling pathway	55/1031	216/7206	1.09562699811e-05
ko04120	Ubiquitin mediated proteolysis	4/1031	138/7206	1.1759823339e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1031	79/7206	2.56256337095e-05
ko04540	Gap junction	36/1031	128/7206	3.58231066046e-05
ko04730	Long-term depression	25/1031	78/7206	5.51598378976e-05
ko04972	Pancreatic secretion	32/1031	111/7206	5.68776618828e-05
ko04141	Protein processing in endoplasmic reticulum	9/1031	184/7206	6.33724454559e-05
ko04915	Estrogen signaling pathway	36/1031	131/7206	7.02959968777e-05
ko04072	Phospholipase D signaling pathway	49/1031	197/7206	7.18562983472e-05
ko04070	Phosphatidylinositol signaling system	32/1031	112/7206	9.66441820674e-05
ko05164	Influenza A	8/1031	167/7206	0.000116910414021
ko04745	Phototransduction - fly	15/1031	38/7206	0.000118775127948
ko03008	Ribosome biogenesis in eukaryotes	1/1031	79/7206	0.000130333231075
ko04014	Ras signaling pathway	63/1031	279/7206	0.00015754531986
ko05414	Dilated cardiomyopathy	31/1031	112/7206	0.000187415988406
ko04612	Antigen processing and presentation	1/1031	77/7206	0.000204739214812
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1031	14/7206	0.00022996174871
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1031	59/7206	0.000470853233773
ko04966	Collecting duct acid secretion	11/1031	26/7206	0.000477856835488
ko04750	Inflammatory mediator regulation of TRP channels	32/1031	122/7206	0.000564528738749
ko04064	NF-kappa B signaling pathway	3/1031	96/7206	0.000576863526609
ko04260	Cardiac muscle contraction	27/1031	98/7206	0.000646022789479
ko04924	Renin secretion	24/1031	86/7206	0.000910720665543
ko05110	Vibrio cholerae infection	19/1031	63/7206	0.000966957800535
ko04640	Hematopoietic cell lineage	1/1031	64/7206	0.000977636153984
ko04110	Cell cycle	8/1031	145/7206	0.00110380967915
ko05140	Leishmaniasis	2/1031	75/7206	0.00137932504483
ko00240	Pyrimidine metabolism	5/1031	110/7206	0.00144545197847
ko05205	Proteoglycans in cancer	22/1031	271/7206	0.00192616957075
ko04217	Necroptosis	12/1031	178/7206	0.00224967516652
ko03018	RNA degradation	3/1031	84/7206	0.00246317547789
ko04923	Regulation of lipolysis in adipocytes	21/1031	77/7206	0.00270283244333
ko00480	Glutathione metabolism	1/1031	55/7206	0.0032660648719
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1031	182/7206	0.00360829364318
ko04371	Apelin signaling pathway	39/1031	177/7206	0.00455432229308
ko05169	Epstein-Barr virus infection	16/1031	206/7206	0.00460460311668
ko00590	Arachidonic acid metabolism	1/1031	52/7206	0.00487512157475
ko05162	Measles	7/1031	120/7206	0.00534720103865
ko04146	Peroxisome	4/1031	89/7206	0.00543556919377
ko04976	Bile secretion	21/1031	80/7206	0.00544971101824
ko05161	Hepatitis B	13/1031	173/7206	0.00801748216263
ko00330	Arginine and proline metabolism	2/1031	61/7206	0.00911617274271
ko04930	Type II diabetes mellitus	15/1031	54/7206	0.00951745872833
ko04214	Apoptosis - fly	3/1031	72/7206	0.0101500029329
ko04350	TGF-beta signaling pathway	6/1031	103/7206	0.010194318188
ko00310	Lysine degradation	3/1031	73/7206	0.0104383442618
ko03420	Nucleotide excision repair	1/1031	46/7206	0.0108230959766
ko04015	Rap1 signaling pathway	55/1031	278/7206	0.0110049020884
ko00260	Glycine, serine and threonine metabolism	1/1031	48/7206	0.0111505620459
ko04973	Carbohydrate digestion and absorption	12/1031	42/7206	0.0137392958541
ko03320	PPAR signaling pathway	3/1031	69/7206	0.0143586756824
ko03022	Basal transcription factors	1/1031	44/7206	0.0160784736963
ko00071	Fatty acid degradation	1/1031	45/7206	0.0164696981427
ko04912	GnRH signaling pathway	27/1031	122/7206	0.0181626266638
ko04062	Chemokine signaling pathway	41/1031	201/7206	0.0181937765364
ko05034	Alcoholism	47/1031	238/7206	0.0183475884284
ko04658	Th1 and Th2 cell differentiation	6/1031	96/7206	0.0187158433628
ko00280	Valine, leucine and isoleucine degradation	2/1031	54/7206	0.0188997009108
ko05321	Inflammatory bowel disease (IBD)	2/1031	56/7206	0.0194078659344
ko04657	IL-17 signaling pathway	5/1031	87/7206	0.0197761824606
ko05145	Toxoplasmosis	9/1031	126/7206	0.0200036485803
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1031	100/7206	0.0201032515895
ko00140	Steroid hormone biosynthesis	1/1031	41/7206	0.0238008163594
ko00983	Drug metabolism - other enzymes	1/1031	42/7206	0.0242991426552
ko04964	Proximal tubule bicarbonate reclamation	9/1031	29/7206	0.0278089182989
ko04622	RIG-I-like receptor signaling pathway	3/1031	62/7206	0.0281859088024
ko04916	Melanogenesis	30/1031	142/7206	0.0283039552959
ko01200	Carbon metabolism	10/1031	128/7206	0.0305040823564
ko04140	Autophagy - animal	14/1031	164/7206	0.0317039013328
ko00562	Inositol phosphate metabolism	20/1031	89/7206	0.0326295874201
ko05231	Choline metabolism in cancer	28/1031	134/7206	0.0337508850242
ko04626	Plant-pathogen interaction	6/1031	18/7206	0.0339236453402
ko05016	Huntington's disease	20/1031	215/7206	0.0371362149647
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1031	40/7206	0.0372292269485
ko05219	Bladder cancer	2/1031	48/7206	0.0389177393199
ko00380	Tryptophan metabolism	2/1031	50/7206	0.039760020647
ko04918	Thyroid hormone synthesis	19/1031	86/7206	0.0438688922127
ko04630	Jak-STAT signaling pathway	11/1031	132/7206	0.0450790156234
ko05133	Pertussis	6/1031	87/7206	0.0451242249528