ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1191	423/7206	7.41148638139e-53
ko04724	Glutamatergic synapse	95/1191	152/7206	5.15663895169e-38
ko05033	Nicotine addiction	49/1191	56/7206	1.50386696742e-31
ko04713	Circadian entrainment	80/1191	136/7206	1.76414851937e-29
ko05032	Morphine addiction	70/1191	110/7206	6.37472327289e-29
ko04727	GABAergic synapse	68/1191	110/7206	5.11483794805e-27
ko04728	Dopaminergic synapse	89/1191	185/7206	4.21609029864e-24
ko04725	Cholinergic synapse	80/1191	160/7206	3.95607662451e-23
ko04721	Synaptic vesicle cycle	52/1191	80/7206	2.15418724409e-22
ko04723	Retrograde endocannabinoid signaling	80/1191	175/7206	5.19130669277e-20
ko04024	cAMP signaling pathway	106/1191	279/7206	1.20587899311e-18
ko04020	Calcium signaling pathway	102/1191	265/7206	2.73921933333e-18
ko04726	Serotonergic synapse	64/1191	137/7206	8.20088645945e-17
ko04911	Insulin secretion	57/1191	117/7206	3.87004685974e-16
ko05031	Amphetamine addiction	48/1191	91/7206	1.5896923811e-15
ko04921	Oxytocin signaling pathway	82/1191	209/7206	2.28255513525e-15
ko04720	Long-term potentiation	50/1191	99/7206	4.09336305347e-15
ko04744	Phototransduction	27/1191	36/7206	1.24072741389e-14
ko04742	Taste transduction	36/1191	61/7206	5.695614695e-14
ko04970	Salivary secretion	44/1191	95/7206	8.57360470476e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1191	205/7206	2.05088814093e-11
ko03040	Spliceosome	1/1191	145/7206	1.96545432153e-10
ko04925	Aldosterone synthesis and secretion	44/1191	105/7206	4.98594278061e-10
ko04740	Olfactory transduction	36/1191	80/7206	1.84318934723e-09
ko04971	Gastric acid secretion	41/1191	98/7206	2.07214199819e-09
ko05030	Cocaine addiction	32/1191	73/7206	3.2099915383e-08
ko04070	Phosphatidylinositol signaling system	42/1191	112/7206	9.36361956663e-08
ko04360	Axon guidance	70/1191	233/7206	2.05354363309e-07
ko04022	cGMP-PKG signaling pathway	65/1191	216/7206	5.4161783385e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1191	74/7206	6.88036289993e-07
ko04060	Cytokine-cytokine receptor interaction	9/1191	191/7206	8.42400378111e-07
ko04621	NOD-like receptor signaling pathway	6/1191	157/7206	1.066506535e-06
ko03013	RNA transport	7/1191	166/7206	1.27095427815e-06
ko05203	Viral carcinogenesis	19/1191	277/7206	1.99643443544e-06
ko04966	Collecting duct acid secretion	15/1191	26/7206	2.17141815698e-06
ko05322	Systemic lupus erythematosus	6/1191	151/7206	2.21481383844e-06
ko05168	Herpes simplex infection	9/1191	182/7206	2.33977118461e-06
ko04730	Long-term depression	30/1191	78/7206	3.26146538195e-06
ko04072	Phospholipase D signaling pathway	58/1191	197/7206	5.5959364445e-06
ko04141	Protein processing in endoplasmic reticulum	10/1191	184/7206	7.16404949102e-06
ko04745	Phototransduction - fly	18/1191	38/7206	9.01425848084e-06
ko04540	Gap junction	41/1191	128/7206	1.13913731072e-05
ko04972	Pancreatic secretion	37/1191	111/7206	1.31078675875e-05
ko04120	Ubiquitin mediated proteolysis	6/1191	138/7206	1.39075794424e-05
ko04010	MAPK signaling pathway	83/1191	321/7206	1.43750568886e-05
ko04514	Cell adhesion molecules (CAMs)	41/1191	130/7206	2.09769147649e-05
ko04110	Cell cycle	7/1191	145/7206	2.25361151922e-05
ko05164	Influenza A	10/1191	167/7206	5.2551336003e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1191	122/7206	6.06285084766e-05
ko04924	Renin secretion	29/1191	86/7206	9.54365983841e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1191	79/7206	0.00010317036725
ko05110	Vibrio cholerae infection	23/1191	63/7206	0.000108044302698
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1191	59/7206	0.000117739133343
ko04612	Antigen processing and presentation	2/1191	77/7206	0.00016859722363
ko04610	Complement and coagulation cascades	2/1191	79/7206	0.00017522279534
ko03008	Ribosome biogenesis in eukaryotes	2/1191	79/7206	0.00017522279534
ko04014	Ras signaling pathway	70/1191	279/7206	0.000197565033912
ko05414	Dilated cardiomyopathy	34/1191	112/7206	0.000260428002534
ko04915	Estrogen signaling pathway	38/1191	131/7206	0.000309369520752
ko04976	Bile secretion	26/1191	80/7206	0.000384331381782
ko04922	Glucagon signaling pathway	37/1191	128/7206	0.00041752692093
ko04260	Cardiac muscle contraction	30/1191	98/7206	0.000497465565663
ko04371	Apelin signaling pathway	47/1191	177/7206	0.00064667919412
ko05169	Epstein-Barr virus infection	17/1191	206/7206	0.000787645732276
ko00520	Amino sugar and nucleotide sugar metabolism	1/1191	55/7206	0.000847647240211
ko04626	Plant-pathogen interaction	9/1191	18/7206	0.00104547814143
ko04064	NF-kappa B signaling pathway	5/1191	96/7206	0.00127272632042
ko04710	Circadian rhythm	16/1191	43/7206	0.00127742257069
ko04912	GnRH signaling pathway	34/1191	122/7206	0.00130714977526
ko04330	Notch signaling pathway	2/1191	62/7206	0.00178151404639
ko05162	Measles	8/1191	120/7206	0.00181794653703
ko00590	Arachidonic acid metabolism	1/1191	52/7206	0.00204310451239
ko05231	Choline metabolism in cancer	36/1191	134/7206	0.00211228822512
ko04973	Carbohydrate digestion and absorption	15/1191	42/7206	0.00250616486804
ko00240	Pyrimidine metabolism	7/1191	110/7206	0.00260776378327
ko04923	Regulation of lipolysis in adipocytes	23/1191	77/7206	0.00304989898329
ko04146	Peroxisome	5/1191	89/7206	0.00360467916554
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1191	14/7206	0.00387620572481
ko05144	Malaria	1/1191	45/7206	0.00438110001141
ko00071	Fatty acid degradation	1/1191	45/7206	0.00438110001141
ko03420	Nucleotide excision repair	1/1191	46/7206	0.00441309540192
ko04964	Proximal tubule bicarbonate reclamation	11/1191	29/7206	0.00461462834253
ko04960	Aldosterone-regulated sodium reabsorption	14/1191	41/7206	0.0050970450065
ko05214	Glioma	23/1191	79/7206	0.00536970483463
ko04930	Type II diabetes mellitus	17/1191	54/7206	0.00544663193008
ko00480	Glutathione metabolism	2/1191	55/7206	0.00563786874931
ko04916	Melanogenesis	36/1191	142/7206	0.00604930663809
ko03022	Basal transcription factors	1/1191	44/7206	0.00674872781112
ko00310	Lysine degradation	4/1191	73/7206	0.00677823365895
ko05140	Leishmaniasis	4/1191	75/7206	0.00701471597172
ko05145	Toxoplasmosis	10/1191	126/7206	0.00732274706895
ko05205	Proteoglycans in cancer	29/1191	271/7206	0.00747070041796
ko04918	Thyroid hormone synthesis	24/1191	86/7206	0.00780132487324
ko04622	RIG-I-like receptor signaling pathway	3/1191	62/7206	0.00918798790966
ko04214	Apoptosis - fly	4/1191	72/7206	0.00973175198629
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1191	40/7206	0.00987080584927
ko04015	Rap1 signaling pathway	62/1191	278/7206	0.0105194848296
ko04062	Chemokine signaling pathway	47/1191	201/7206	0.011870717723
ko04657	IL-17 signaling pathway	6/1191	87/7206	0.0127931252382
ko00562	Inositol phosphate metabolism	24/1191	89/7206	0.0135775358066
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1191	100/7206	0.0142060627429
ko04210	Apoptosis	18/1191	180/7206	0.0146085518319
ko00630	Glyoxylate and dicarboxylate metabolism	1/1191	38/7206	0.0147721183617
ko04350	TGF-beta signaling pathway	8/1191	103/7206	0.0153096397965
ko03018	RNA degradation	6/1191	84/7206	0.0173510325483
ko04630	Jak-STAT signaling pathway	12/1191	132/7206	0.0177524429635
ko04115	p53 signaling pathway	5/1191	74/7206	0.0182052401231
ko04217	Necroptosis	18/1191	178/7206	0.0184282076278
ko01524	Platinum drug resistance	5/1191	76/7206	0.0185618914987
ko05321	Inflammatory bowel disease (IBD)	3/1191	56/7206	0.0185741215778
ko05016	Huntington's disease	23/1191	215/7206	0.0193924430313
ko00512	Mucin type O-glycan biosynthesis	10/1191	29/7206	0.0196068935657
ko05166	HTLV-I infection	34/1191	292/7206	0.0197066449104
ko05034	Alcoholism	53/1191	238/7206	0.020604800246
ko05131	Shigellosis	6/1191	82/7206	0.0237225554841
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1191	182/7206	0.02565321481
ko04658	Th1 and Th2 cell differentiation	8/1191	96/7206	0.0266430727142
ko04114	Oocyte meiosis	33/1191	139/7206	0.0276919372562
ko04213	Longevity regulating pathway - multiple species	22/1191	86/7206	0.0281757775962
ko05418	Fluid shear stress and atherosclerosis	18/1191	173/7206	0.0290229278287
ko05161	Hepatitis B	18/1191	173/7206	0.0290229278287
ko05133	Pertussis	7/1191	87/7206	0.0291651141497
ko05230	Central carbon metabolism in cancer	21/1191	81/7206	0.0334911837342
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1191	92/7206	0.0336162209197
ko03320	PPAR signaling pathway	5/1191	69/7206	0.0340328027745
ko00983	Drug metabolism - other enzymes	2/1191	42/7206	0.0364749883968
ko05202	Transcriptional misregulation in cancer	21/1191	188/7206	0.0462977203064
ko04270	Vascular smooth muscle contraction	35/1191	154/7206	0.0474351881576
ko04711	Circadian rhythm - fly	5/1191	13/7206	0.0494097252681
ko04012	ErbB signaling pathway	26/1191	109/7206	0.0499563296139