ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 45/631 191/7206 3.63739080258e-10 ko04380 Osteoclast differentiation 35/631 134/7206 1.91862788003e-09 ko04621 NOD-like receptor signaling pathway 37/631 157/7206 1.3926230913e-08 ko04650 Natural killer cell mediated cytotoxicity 27/631 97/7206 3.26948193791e-08 ko05321 Inflammatory bowel disease (IBD) 19/631 56/7206 1.1781387971e-07 ko00120 Primary bile acid biosynthesis 11/631 20/7206 1.71860852409e-07 ko05340 Primary immunodeficiency 13/631 30/7206 4.64761662235e-07 ko05164 Influenza A 35/631 167/7206 9.25919906538e-07 ko04064 NF-kappa B signaling pathway 24/631 96/7206 1.63869650827e-06 ko04620 Toll-like receptor signaling pathway 24/631 100/7206 3.57520006665e-06 ko05140 Leishmaniasis 20/631 75/7206 4.16349769536e-06 ko04137 Mitophagy - animal 21/631 82/7206 4.848242216e-06 ko00051 Fructose and mannose metabolism 14/631 42/7206 7.04014174826e-06 ko05162 Measles 26/631 120/7206 1.05975132286e-05 ko05330 Allograft rejection 10/631 24/7206 1.55883901635e-05 ko05152 Tuberculosis 34/631 187/7206 3.31933683339e-05 ko05145 Toxoplasmosis 26/631 126/7206 3.5098775758e-05 ko03040 Spliceosome 1/631 145/7206 3.95949258519e-05 ko04710 Circadian rhythm 13/631 43/7206 4.86332788162e-05 ko04660 T cell receptor signaling pathway 25/631 124/7206 6.69837308742e-05 ko03013 RNA transport 2/631 166/7206 6.74799762929e-05 ko04217 Necroptosis 32/631 178/7206 7.1402100555e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/631 191/7206 0.000128874358473 ko04659 Th17 cell differentiation 22/631 106/7206 0.000155586290811 ko03010 Ribosome 1/631 129/7206 0.000200588938381 ko04630 Jak-STAT signaling pathway 25/631 132/7206 0.000232041973693 ko04668 TNF signaling pathway 23/631 120/7206 0.000260804965049 ko05144 Malaria 12/631 45/7206 0.000353148456563 ko04610 Complement and coagulation cascades 17/631 79/7206 0.000385343885418 ko05133 Pertussis 18/631 87/7206 0.000436336175069 ko05332 Graft-versus-host disease 7/631 18/7206 0.000514624044036 ko05320 Autoimmune thyroid disease 9/631 29/7206 0.000576987105688 ko04658 Th1 and Th2 cell differentiation 19/631 96/7206 0.00069223757004 ko04662 B cell receptor signaling pathway 18/631 88/7206 0.000803661090678 ko04672 Intestinal immune network for IgA production 10/631 37/7206 0.000971630880677 ko04390 Hippo signaling pathway 5/631 188/7206 0.000993613282002 ko04110 Cell cycle 3/631 145/7206 0.0015803598781 ko04623 Cytosolic DNA-sensing pathway 10/631 41/7206 0.00227122189914 ko04622 RIG-I-like receptor signaling pathway 13/631 62/7206 0.00233896854216 ko05310 Asthma 6/631 17/7206 0.00234913945222 ko05168 Herpes simplex infection 28/631 182/7206 0.00309558213723 ko05150 Staphylococcus aureus infection 9/631 36/7206 0.00311334628286 ko04640 Hematopoietic cell lineage 13/631 64/7206 0.00314408428426 ko04612 Antigen processing and presentation 15/631 77/7206 0.00324337591963 ko04068 FoxO signaling pathway 26/631 167/7206 0.00333427541895 ko04136 Autophagy - other 8/631 31/7206 0.00424388112367 ko00592 alpha-Linolenic acid metabolism 6/631 19/7206 0.00442601491252 ko03015 mRNA surveillance pathway 1/631 93/7206 0.00450410617907 ko00590 Arachidonic acid metabolism 11/631 52/7206 0.0046180488295 ko04210 Apoptosis 27/631 180/7206 0.00478217059458 ko04310 Wnt signaling pathway 6/631 181/7206 0.0050098617821 ko00620 Pyruvate metabolism 10/631 46/7206 0.00554659101815 ko05161 Hepatitis B 26/631 173/7206 0.00593834317952 ko00350 Tyrosine metabolism 8/631 33/7206 0.00639154778606 ko04146 Peroxisome 16/631 89/7206 0.00673055133608 ko05323 Rheumatoid arthritis 16/631 89/7206 0.00673055133608 ko04062 Chemokine signaling pathway 29/631 201/7206 0.00727692669185 ko00140 Steroid hormone biosynthesis 9/631 41/7206 0.00781450523836 ko05224 Breast cancer 6/631 174/7206 0.00924109357076 ko05034 Alcoholism 10/631 238/7206 0.00975288398974 ko05134 Legionellosis 13/631 74/7206 0.0122560351231 ko00360 Phenylalanine metabolism 5/631 17/7206 0.0128829503702 ko03320 PPAR signaling pathway 12/631 69/7206 0.017352990909 ko04940 Type I diabetes mellitus 7/631 32/7206 0.0185408590514 ko04723 Retrograde endocannabinoid signaling 7/631 175/7206 0.0207528846493 ko04664 Fc epsilon RI signaling pathway 13/631 77/7206 0.022420776815 ko00561 Glycerolipid metabolism 11/631 63/7206 0.0226329156549 ko04391 Hippo signaling pathway - fly 2/631 90/7206 0.0226665443238 ko04922 Glucagon signaling pathway 19/631 128/7206 0.0252148670897 ko05142 Chagas disease (American trypanosomiasis) 19/631 130/7206 0.0265442457297 ko05230 Central carbon metabolism in cancer 13/631 81/7206 0.0278952086875 ko04138 Autophagy - yeast 13/631 81/7206 0.0278952086875 ko05200 Pathways in cancer 30/631 492/7206 0.0313194514271 ko04080 Neuroactive ligand-receptor interaction 25/631 423/7206 0.0329731761415 ko04145 Phagosome 22/631 162/7206 0.0343425443475 ko04611 Platelet activation 22/631 163/7206 0.035417994853 ko00380 Tryptophan metabolism 9/631 50/7206 0.0377472468483 ko00982 Drug metabolism - cytochrome P450 7/631 37/7206 0.0388522945399 ko05160 Hepatitis C 21/631 153/7206 0.0410277227116 ko05206 MicroRNAs in cancer 8/631 177/7206 0.0427225290688 ko04070 Phosphatidylinositol signaling system 16/631 112/7206 0.0430339868344 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 2/631 79/7206 0.0447830889855 ko04360 Axon guidance 12/631 233/7206 0.0452301765916