ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1270	423/7206	1.9426585249e-49
ko04724	Glutamatergic synapse	91/1270	152/7206	5.37079346701e-32
ko05033	Nicotine addiction	48/1270	56/7206	1.01682966321e-28
ko05032	Morphine addiction	67/1270	110/7206	2.05820612085e-24
ko04713	Circadian entrainment	76/1270	136/7206	3.36342963962e-24
ko04727	GABAergic synapse	66/1270	110/7206	1.54292537938e-23
ko04721	Synaptic vesicle cycle	52/1270	80/7206	4.54463228306e-21
ko04728	Dopaminergic synapse	87/1270	185/7206	9.17735204602e-21
ko04725	Cholinergic synapse	75/1270	160/7206	6.07711654991e-18
ko04723	Retrograde endocannabinoid signaling	77/1270	175/7206	1.97338757114e-16
ko04020	Calcium signaling pathway	102/1270	265/7206	3.02501769836e-16
ko04742	Taste transduction	39/1270	61/7206	9.57193292923e-16
ko04024	cAMP signaling pathway	104/1270	279/7206	2.04530833618e-15
ko04726	Serotonergic synapse	62/1270	137/7206	3.76763477492e-14
ko04744	Phototransduction	27/1270	36/7206	6.38930282712e-14
ko04911	Insulin secretion	54/1270	117/7206	6.47315791018e-13
ko04921	Oxytocin signaling pathway	79/1270	209/7206	2.00019586573e-12
ko03040	Spliceosome	1/1270	145/7206	2.59357585617e-11
ko05031	Amphetamine addiction	43/1270	91/7206	5.75740821421e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1270	205/7206	3.55005440821e-10
ko04720	Long-term potentiation	44/1270	99/7206	4.19500037658e-10
ko05203	Viral carcinogenesis	15/1270	277/7206	1.43590662432e-09
ko04360	Axon guidance	78/1270	233/7206	2.57227084911e-09
ko04970	Salivary secretion	41/1270	95/7206	4.84568051788e-09
ko04740	Olfactory transduction	35/1270	80/7206	4.26680073307e-08
ko03013	RNA transport	7/1270	166/7206	2.52124128922e-07
ko05168	Herpes simplex infection	9/1270	182/7206	3.41941745093e-07
ko05030	Cocaine addiction	31/1270	73/7206	5.66337023186e-07
ko04022	cGMP-PKG signaling pathway	67/1270	216/7206	1.10214707589e-06
ko04925	Aldosterone synthesis and secretion	39/1270	105/7206	1.68443374053e-06
ko05322	Systemic lupus erythematosus	7/1270	151/7206	2.30632713993e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1270	74/7206	3.32150986642e-06
ko04621	NOD-like receptor signaling pathway	8/1270	157/7206	3.76234820746e-06
ko05164	Influenza A	9/1270	167/7206	4.26948317104e-06
ko04060	Cytokine-cytokine receptor interaction	12/1270	191/7206	4.83459832468e-06
ko04966	Collecting duct acid secretion	15/1270	26/7206	5.00693976479e-06
ko04971	Gastric acid secretion	36/1270	98/7206	5.77369178867e-06
ko04514	Cell adhesion molecules (CAMs)	43/1270	130/7206	2.00520052664e-05
ko04010	MAPK signaling pathway	86/1270	321/7206	3.3170785601e-05
ko04924	Renin secretion	31/1270	86/7206	4.18435717267e-05
ko04610	Complement and coagulation cascades	2/1270	79/7206	7.18015501275e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1270	79/7206	7.18015501275e-05
ko04070	Phosphatidylinositol signaling system	37/1270	112/7206	7.78977427822e-05
ko05205	Proteoglycans in cancer	25/1270	271/7206	8.95520264895e-05
ko05140	Leishmaniasis	2/1270	75/7206	0.000102447038119
ko04141	Protein processing in endoplasmic reticulum	14/1270	184/7206	0.000115314249095
ko04064	NF-kappa B signaling pathway	4/1270	96/7206	0.000119821317477
ko04972	Pancreatic secretion	36/1270	111/7206	0.00013122441693
ko05169	Epstein-Barr virus infection	17/1270	206/7206	0.00013134367082
ko05161	Hepatitis B	13/1270	173/7206	0.000163286565045
ko04120	Ubiquitin mediated proteolysis	9/1270	138/7206	0.000176453949184
ko05110	Vibrio cholerae infection	23/1270	63/7206	0.000331926253449
ko04745	Phototransduction - fly	16/1270	38/7206	0.000355330925842
ko04146	Peroxisome	4/1270	89/7206	0.000368158835443
ko04540	Gap junction	39/1270	128/7206	0.000371186034915
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1270	79/7206	0.000478620410908
ko04072	Phospholipase D signaling pathway	54/1270	197/7206	0.000581530869139
ko05162	Measles	8/1270	120/7206	0.000649429976793
ko04730	Long-term depression	26/1270	78/7206	0.000795291451736
ko04110	Cell cycle	11/1270	145/7206	0.000843758777519
ko04371	Apelin signaling pathway	49/1270	177/7206	0.000885901640863
ko00240	Pyrimidine metabolism	7/1270	110/7206	0.000906011966355
ko05414	Dilated cardiomyopathy	34/1270	112/7206	0.000986819758856
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1270	14/7206	0.00099952397266
ko04976	Bile secretion	26/1270	80/7206	0.00103844335925
ko04014	Ras signaling pathway	70/1270	279/7206	0.00130716473625
ko04626	Plant-pathogen interaction	9/1270	18/7206	0.00168430045695
ko04260	Cardiac muscle contraction	30/1270	98/7206	0.00184261080782
ko04612	Antigen processing and presentation	4/1270	77/7206	0.00226794842107
ko04964	Proximal tubule bicarbonate reclamation	12/1270	29/7206	0.00230867131764
ko04915	Estrogen signaling pathway	37/1270	131/7206	0.00241348303248
ko05321	Inflammatory bowel disease (IBD)	2/1270	56/7206	0.0024623896347
ko04750	Inflammatory mediator regulation of TRP channels	35/1270	122/7206	0.00247679627618
ko05144	Malaria	1/1270	45/7206	0.00273615125494
ko00071	Fatty acid degradation	1/1270	45/7206	0.00273615125494
ko03420	Nucleotide excision repair	1/1270	46/7206	0.00281062329514
ko00480	Glutathione metabolism	2/1270	55/7206	0.00372345605449
ko04923	Regulation of lipolysis in adipocytes	24/1270	77/7206	0.00372401125048
ko03022	Basal transcription factors	1/1270	44/7206	0.00433083436707
ko04214	Apoptosis - fly	4/1270	72/7206	0.00458431486219
ko00310	Lysine degradation	4/1270	73/7206	0.00474901322801
ko00590	Arachidonic acid metabolism	2/1270	52/7206	0.00537307293746
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1270	59/7206	0.00559933523997
ko00330	Arginine and proline metabolism	3/1270	61/7206	0.00614493658944
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1270	40/7206	0.0062458327792
ko05145	Toxoplasmosis	11/1270	126/7206	0.00637325623466
ko04622	RIG-I-like receptor signaling pathway	3/1270	62/7206	0.00639919564212
ko04657	IL-17 signaling pathway	6/1270	87/7206	0.00653960094399
ko05133	Pertussis	6/1270	87/7206	0.00653960094399
ko04630	Jak-STAT signaling pathway	12/1270	132/7206	0.00768324198312
ko03018	RNA degradation	6/1270	84/7206	0.00891460720125
ko00630	Glyoxylate and dicarboxylate metabolism	1/1270	38/7206	0.00940740821188
ko05131	Shigellosis	6/1270	82/7206	0.0123357957518
ko04640	Hematopoietic cell lineage	4/1270	64/7206	0.0128087567466
ko04115	p53 signaling pathway	5/1270	74/7206	0.0130113210694
ko04658	Th1 and Th2 cell differentiation	8/1270	96/7206	0.0145390024481
ko00982	Drug metabolism - cytochrome P450	1/1270	37/7206	0.0148307831553
ko05166	HTLV-I infection	36/1270	292/7206	0.0148642890061
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1270	182/7206	0.0175770564542
ko04217	Necroptosis	20/1270	178/7206	0.0218066490638
ko04210	Apoptosis	20/1270	180/7206	0.0221263869229
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1270	135/7206	0.0226009476179
ko01524	Platinum drug resistance	6/1270	76/7206	0.022628198834
ko05132	Salmonella infection	9/1270	98/7206	0.0233912386044
ko04620	Toll-like receptor signaling pathway	9/1270	100/7206	0.0236609665032
ko03320	PPAR signaling pathway	5/1270	69/7206	0.0246599798588
ko00562	Inositol phosphate metabolism	24/1270	89/7206	0.0247871985538
ko05016	Huntington's disease	26/1270	215/7206	0.0291594477189
ko04930	Type II diabetes mellitus	16/1270	54/7206	0.0295435804152
ko05215	Prostate cancer	11/1270	111/7206	0.0321243290939
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1270	100/7206	0.0337127112069
ko04922	Glucagon signaling pathway	32/1270	128/7206	0.0343814438698
ko05222	Small cell lung cancer	8/1270	89/7206	0.0344893764135
ko00260	Glycine, serine and threonine metabolism	3/1270	48/7206	0.0358535826901
ko05219	Bladder cancer	3/1270	48/7206	0.0358535826901
ko04510	Focal adhesion	30/1270	240/7206	0.0381530893513
ko04140	Autophagy - animal	19/1270	164/7206	0.0382601878556
ko04710	Circadian rhythm	13/1270	43/7206	0.0419903064548
ko05206	MicroRNAs in cancer	21/1270	177/7206	0.045184686131
ko05320	Autoimmune thyroid disease	1/1270	29/7206	0.0478980543615
ko00280	Valine, leucine and isoleucine degradation	4/1270	54/7206	0.0481208371411
ko05340	Primary immunodeficiency	1/1270	30/7206	0.0499123657545