ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 25/428 79/7206 1.4017855323e-12 ko04974 Protein digestion and absorption 25/428 96/7206 1.63893256941e-10 ko04260 Cardiac muscle contraction 24/428 98/7206 1.50393971024e-09 ko04512 ECM-receptor interaction 20/428 79/7206 1.95091982295e-08 ko00190 Oxidative phosphorylation 25/428 127/7206 7.85307955625e-08 ko05012 Parkinson's disease 27/428 155/7206 3.30037957105e-07 ko04950 Maturity onset diabetes of the young 11/428 29/7206 3.72934521148e-07 ko05410 Hypertrophic cardiomyopathy (HCM) 20/428 100/7206 1.22973143248e-06 ko04977 Vitamin digestion and absorption 9/428 22/7206 2.10307956025e-06 ko00260 Glycine, serine and threonine metabolism 13/428 48/7206 2.72058979474e-06 ko05016 Huntington's disease 30/428 215/7206 1.06276298623e-05 ko05010 Alzheimer's disease 28/428 202/7206 2.40735784283e-05 ko05414 Dilated cardiomyopathy 19/428 112/7206 2.76676472061e-05 ko04062 Chemokine signaling pathway 1/428 201/7206 0.000103871618735 ko00020 Citrate cycle (TCA cycle) 9/428 35/7206 0.000149274353032 ko04975 Fat digestion and absorption 9/428 35/7206 0.000149274353032 ko04072 Phospholipase D signaling pathway 1/428 197/7206 0.000161323657975 ko05203 Viral carcinogenesis 4/428 277/7206 0.000372996802059 ko04978 Mineral absorption 9/428 40/7206 0.000443431199648 ko01200 Carbon metabolism 18/428 128/7206 0.00051803958093 ko00350 Tyrosine metabolism 8/428 33/7206 0.000539161163881 ko03013 RNA transport 1/428 166/7206 0.000704993591649 ko05150 Staphylococcus aureus infection 8/428 36/7206 0.00100433330173 ko04140 Autophagy - animal 1/428 164/7206 0.00111054085962 ko00280 Valine, leucine and isoleucine degradation 10/428 54/7206 0.00111060969652 ko04964 Proximal tubule bicarbonate reclamation 7/428 29/7206 0.00123555870333 ko00010 Glycolysis / Gluconeogenesis 12/428 74/7206 0.00125296653804 ko00620 Pyruvate metabolism 9/428 46/7206 0.00130110663621 ko05034 Alcoholism 4/428 238/7206 0.00196713397312 ko04144 Endocytosis 8/428 342/7206 0.00211955202134 ko04110 Cell cycle 1/428 145/7206 0.00220586325984 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/428 79/7206 0.00223479441911 ko00330 Arginine and proline metabolism 10/428 61/7206 0.00288593095507 ko05161 Hepatitis B 2/428 173/7206 0.00296707800433 ko00480 Glutathione metabolism 9/428 55/7206 0.0046780023324 ko05231 Choline metabolism in cancer 1/428 134/7206 0.00476279336962 ko04932 Non-alcoholic fatty liver disease (NAFLD) 20/428 182/7206 0.00651484827345 ko04141 Protein processing in endoplasmic reticulum 3/428 184/7206 0.00683580288563 ko04724 Glutamatergic synapse 2/428 152/7206 0.00856510082916 ko04024 cAMP signaling pathway 7/428 279/7206 0.00943186010605 ko05168 Herpes simplex infection 3/428 182/7206 0.00985875848017 ko05169 Epstein-Barr virus infection 4/428 206/7206 0.0101107972457 ko04510 Focal adhesion 24/428 240/7206 0.0115529115972 ko00340 Histidine metabolism 5/428 25/7206 0.0142797675084 ko05215 Prostate cancer 1/428 111/7206 0.0143942210225 ko04261 Adrenergic signaling in cardiomyocytes 21/428 205/7206 0.0150644179463 ko00410 beta-Alanine metabolism 6/428 35/7206 0.0158295445295 ko01230 Biosynthesis of amino acids 11/428 85/7206 0.0167018910499 ko05164 Influenza A 3/428 167/7206 0.0187664403618 ko00270 Cysteine and methionine metabolism 7/428 47/7206 0.0198489944901 ko00982 Drug metabolism - cytochrome P450 6/428 37/7206 0.0205252108413 ko04659 Th17 cell differentiation 1/428 106/7206 0.0209596571803 ko04012 ErbB signaling pathway 1/428 109/7206 0.0217129562233 ko00630 Glyoxylate and dicarboxylate metabolism 6/428 38/7206 0.0231935488239 ko04915 Estrogen signaling pathway 2/428 131/7206 0.0241686248449 ko04621 NOD-like receptor signaling pathway 3/428 157/7206 0.025446837105 ko04722 Neurotrophin signaling pathway 3/428 160/7206 0.0259159370484 ko05152 Tuberculosis 4/428 187/7206 0.0262561572296 ko04071 Sphingolipid signaling pathway 3/428 162/7206 0.0265274185409 ko04976 Bile secretion 10/428 80/7206 0.0266280743715 ko04014 Ras signaling pathway 8/428 279/7206 0.0269096133452 ko00980 Metabolism of xenobiotics by cytochrome P450 6/428 40/7206 0.0292069710932 ko04720 Long-term potentiation 1/428 99/7206 0.0302437954212 ko04620 Toll-like receptor signaling pathway 1/428 100/7206 0.030467611176 ko00472 D-Arginine and D-ornithine metabolism 2/428 5/7206 0.0312183639173 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/428 5/7206 0.0312183639173 ko00311 Penicillin and cephalosporin biosynthesis 2/428 5/7206 0.0312183639173 ko04211 Longevity regulating pathway 2/428 123/7206 0.0339268477315 ko04660 T cell receptor signaling pathway 2/428 124/7206 0.0339469402169 ko04142 Lysosome 3/428 151/7206 0.0351586608572 ko04210 Apoptosis 4/428 180/7206 0.0355745881685 ko00830 Retinol metabolism 6/428 42/7206 0.0361631696752 ko05031 Amphetamine addiction 1/428 91/7206 0.04341408682 ko00730 Thiamine metabolism 3/428 14/7206 0.0464146923604 ko00430 Taurine and hypotaurine metabolism 3/428 14/7206 0.0464146923604 ko04668 TNF signaling pathway 2/428 120/7206 0.0483235967595 ko00640 Propanoate metabolism 5/428 34/7206 0.0484306857558 ko04666 Fc gamma R-mediated phagocytosis 2/428 122/7206 0.0494554997626