ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1106	423/7206	4.90908275904e-54
ko04724	Glutamatergic synapse	87/1106	152/7206	2.869781448e-33
ko05033	Nicotine addiction	47/1106	56/7206	4.4389519181e-30
ko05032	Morphine addiction	67/1106	110/7206	4.72516121933e-28
ko04713	Circadian entrainment	75/1106	136/7206	2.38950455249e-27
ko04727	GABAergic synapse	64/1106	110/7206	2.97995384121e-25
ko04728	Dopaminergic synapse	86/1106	185/7206	2.53800549069e-24
ko04721	Synaptic vesicle cycle	49/1106	80/7206	5.85983462341e-21
ko04024	cAMP signaling pathway	103/1106	279/7206	1.57310748373e-19
ko04725	Cholinergic synapse	72/1106	160/7206	1.65604047522e-19
ko04723	Retrograde endocannabinoid signaling	76/1106	175/7206	2.09828748734e-19
ko04020	Calcium signaling pathway	97/1106	265/7206	5.174670755e-18
ko04742	Taste transduction	37/1106	61/7206	6.29146477644e-16
ko04911	Insulin secretion	54/1106	117/7206	1.67036994864e-15
ko04726	Serotonergic synapse	59/1106	137/7206	4.10855469275e-15
ko04921	Oxytocin signaling pathway	75/1106	209/7206	1.15188988362e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1106	205/7206	1.72477094789e-12
ko05031	Amphetamine addiction	42/1106	91/7206	2.42846297163e-12
ko04744	Phototransduction	24/1106	36/7206	4.53980970634e-12
ko04720	Long-term potentiation	42/1106	99/7206	7.1700465112e-11
ko04970	Salivary secretion	40/1106	95/7206	2.69723180546e-10
ko03040	Spliceosome	1/1106	145/7206	1.37438281675e-09
ko04360	Axon guidance	72/1106	233/7206	1.38353528434e-09
ko04740	Olfactory transduction	33/1106	80/7206	1.84818316314e-08
ko05203	Viral carcinogenesis	13/1106	277/7206	2.05031698816e-08
ko05030	Cocaine addiction	31/1106	73/7206	2.20019024666e-08
ko04925	Aldosterone synthesis and secretion	38/1106	105/7206	1.27428373896e-07
ko04971	Gastric acid secretion	36/1106	98/7206	2.19663880935e-07
ko04010	MAPK signaling pathway	83/1106	321/7206	6.81470197006e-07
ko04621	NOD-like receptor signaling pathway	5/1106	157/7206	9.6862041904e-07
ko04060	Cytokine-cytokine receptor interaction	8/1106	191/7206	1.1814162363e-06
ko03013	RNA transport	6/1106	166/7206	1.78355458848e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1106	74/7206	1.80408248964e-06
ko05164	Influenza A	6/1106	167/7206	1.85512907779e-06
ko04022	cGMP-PKG signaling pathway	60/1106	216/7206	1.93358625229e-06
ko05322	Systemic lupus erythematosus	5/1106	151/7206	3.10003434807e-06
ko05168	Herpes simplex infection	8/1106	182/7206	3.42767887189e-06
ko04120	Ubiquitin mediated proteolysis	4/1106	138/7206	3.48784395834e-06
ko04141	Protein processing in endoplasmic reticulum	8/1106	184/7206	3.52076339993e-06
ko04540	Gap junction	40/1106	128/7206	5.00313330848e-06
ko04924	Renin secretion	30/1106	86/7206	6.05412987206e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1106	79/7206	9.72786781042e-06
ko04745	Phototransduction - fly	17/1106	38/7206	1.49743111826e-05
ko04514	Cell adhesion molecules (CAMs)	39/1106	130/7206	2.01685694561e-05
ko04070	Phosphatidylinositol signaling system	35/1106	112/7206	2.6737187048e-05
ko04972	Pancreatic secretion	34/1106	111/7206	4.56401118917e-05
ko05414	Dilated cardiomyopathy	34/1106	112/7206	5.14114786674e-05
ko04260	Cardiac muscle contraction	30/1106	98/7206	0.000108010770261
ko05110	Vibrio cholerae infection	22/1106	63/7206	0.000121302230771
ko04014	Ras signaling pathway	67/1106	279/7206	0.00012210405699
ko04064	NF-kappa B signaling pathway	3/1106	96/7206	0.000169134903699
ko04750	Inflammatory mediator regulation of TRP channels	35/1106	122/7206	0.000182657040929
ko04966	Collecting duct acid secretion	12/1106	26/7206	0.00019138611553
ko04730	Long-term depression	25/1106	78/7206	0.00019176252256
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1106	59/7206	0.000360352782329
ko05205	Proteoglycans in cancer	22/1106	271/7206	0.000401522562989
ko03008	Ribosome biogenesis in eukaryotes	2/1106	79/7206	0.000411887224245
ko05169	Epstein-Barr virus infection	15/1106	206/7206	0.000555610075065
ko05140	Leishmaniasis	2/1106	75/7206	0.000597390056698
ko04612	Antigen processing and presentation	2/1106	77/7206	0.000626929624488
ko04072	Phospholipase D signaling pathway	48/1106	197/7206	0.00085223838137
ko04110	Cell cycle	9/1106	145/7206	0.00101890946328
ko05161	Hepatitis B	12/1106	173/7206	0.00122692531556
ko05162	Measles	7/1106	120/7206	0.00197950033617
ko00480	Glutathione metabolism	1/1106	55/7206	0.00209373460931
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1106	182/7206	0.00240248946171
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1106	14/7206	0.00250327390669
ko04146	Peroxisome	4/1106	89/7206	0.00263354909945
ko04640	Hematopoietic cell lineage	2/1106	64/7206	0.00279433323921
ko00590	Arachidonic acid metabolism	1/1106	52/7206	0.00311372383795
ko01524	Platinum drug resistance	3/1106	76/7206	0.0033870291177
ko04217	Necroptosis	14/1106	178/7206	0.00419190006063
ko04976	Bile secretion	22/1106	80/7206	0.00455843499927
ko04630	Jak-STAT signaling pathway	9/1106	132/7206	0.00467740745148
ko04214	Apoptosis - fly	3/1106	72/7206	0.0047260689104
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1106	100/7206	0.00492594635774
ko05215	Prostate cancer	7/1106	111/7206	0.00506822631716
ko04371	Apelin signaling pathway	41/1106	177/7206	0.00573817405628
ko00330	Arginine and proline metabolism	2/1106	61/7206	0.00629558073814
ko04915	Estrogen signaling pathway	32/1106	131/7206	0.00661185818902
ko03420	Nucleotide excision repair	1/1106	46/7206	0.00693348604561
ko00240	Pyrimidine metabolism	7/1106	110/7206	0.00705918983985
ko00260	Glycine, serine and threonine metabolism	1/1106	48/7206	0.00736910840322
ko05145	Toxoplasmosis	9/1106	126/7206	0.00831619543191
ko05321	Inflammatory bowel disease (IBD)	2/1106	56/7206	0.00866959943291
ko04657	IL-17 signaling pathway	5/1106	87/7206	0.0101369994595
ko03022	Basal transcription factors	1/1106	44/7206	0.0104255867435
ko05144	Malaria	1/1106	45/7206	0.0108017637879
ko00071	Fatty acid degradation	1/1106	45/7206	0.0108017637879
ko04626	Plant-pathogen interaction	7/1106	18/7206	0.0132591628685
ko04015	Rap1 signaling pathway	58/1106	278/7206	0.0135250237911
ko03018	RNA degradation	5/1106	84/7206	0.0139214218532
ko00310	Lysine degradation	4/1106	73/7206	0.0139927863581
ko04668	TNF signaling pathway	9/1106	120/7206	0.014591177935
ko04210	Apoptosis	16/1106	180/7206	0.0154502442616
ko00140	Steroid hormone biosynthesis	1/1106	41/7206	0.0154652749218
ko04923	Regulation of lipolysis in adipocytes	20/1106	77/7206	0.015762765645
ko00983	Drug metabolism - other enzymes	1/1106	42/7206	0.0158675960436
ko04620	Toll-like receptor signaling pathway	7/1106	100/7206	0.0169659362918
ko04510	Focal adhesion	24/1106	240/7206	0.0177134751064
ko05131	Shigellosis	5/1106	82/7206	0.0194365667425
ko04622	RIG-I-like receptor signaling pathway	3/1106	62/7206	0.0197369855422
ko04912	GnRH signaling pathway	28/1106	122/7206	0.0225790579321
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1106	40/7206	0.0243862836319
ko05418	Fluid shear stress and atherosclerosis	16/1106	173/7206	0.0243890026974
ko05133	Pertussis	6/1106	87/7206	0.0243915710678
ko04916	Melanogenesis	32/1106	142/7206	0.0245677466142
ko05222	Small cell lung cancer	6/1106	89/7206	0.0250115921062
ko05219	Bladder cancer	2/1106	48/7206	0.0262661431577
ko00380	Tryptophan metabolism	2/1106	50/7206	0.0275223729662
ko04140	Autophagy - animal	15/1106	164/7206	0.0276462780272
ko04350	TGF-beta signaling pathway	8/1106	103/7206	0.0276605573272
ko04658	Th1 and Th2 cell differentiation	7/1106	96/7206	0.0310268046866
ko04964	Proximal tubule bicarbonate reclamation	9/1106	29/7206	0.0332595894519
ko01200	Carbon metabolism	11/1106	128/7206	0.0344875789299
ko04115	p53 signaling pathway	5/1106	74/7206	0.0352592407687
ko00982	Drug metabolism - cytochrome P450	1/1106	37/7206	0.0355943642616
ko04930	Type II diabetes mellitus	14/1106	54/7206	0.0370017510891
ko05166	HTLV-I infection	32/1106	292/7206	0.0377793884923
ko00620	Pyruvate metabolism	2/1106	46/7206	0.0380481767441
ko00270	Cysteine and methionine metabolism	2/1106	47/7206	0.0391091308879
ko04391	Hippo signaling pathway - fly	21/1106	90/7206	0.0394560375672
ko04270	Vascular smooth muscle contraction	33/1106	154/7206	0.0413063168862
ko04918	Thyroid hormone synthesis	20/1106	86/7206	0.0493603020202