ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 71/760 152/7206 1.63300825474e-30 ko05033 Nicotine addiction 41/760 56/7206 1.14614705805e-28 ko04080 Neuroactive ligand-receptor interaction 117/760 423/7206 1.58596260628e-24 ko04727 GABAergic synapse 52/760 110/7206 7.07488075321e-23 ko05032 Morphine addiction 52/760 110/7206 7.07488075321e-23 ko04728 Dopaminergic synapse 69/760 185/7206 1.31076780364e-22 ko04723 Retrograde endocannabinoid signaling 63/760 175/7206 8.74359082725e-20 ko04713 Circadian entrainment 53/760 136/7206 1.39688566046e-18 ko04721 Synaptic vesicle cycle 38/760 80/7206 4.11549483338e-17 ko04024 cAMP signaling pathway 75/760 279/7206 3.86941803999e-15 ko04725 Cholinergic synapse 53/760 160/7206 4.8901886095e-15 ko04726 Serotonergic synapse 44/760 137/7206 3.68115742047e-12 ko04744 Phototransduction 20/760 36/7206 3.2476857522e-11 ko04911 Insulin secretion 38/760 117/7206 7.75196308864e-11 ko04020 Calcium signaling pathway 64/760 265/7206 1.24333019195e-10 ko04921 Oxytocin signaling pathway 54/760 209/7206 2.27781697223e-10 ko04261 Adrenergic signaling in cardiomyocytes 52/760 205/7206 8.72825193562e-10 ko05031 Amphetamine addiction 31/760 91/7206 1.17550436856e-09 ko04720 Long-term potentiation 32/760 99/7206 2.84562674353e-09 ko04010 MAPK signaling pathway 68/760 321/7206 1.21409189967e-08 ko05030 Cocaine addiction 25/760 73/7206 4.28104235304e-08 ko04742 Taste transduction 22/760 61/7206 9.68410965408e-08 ko03040 Spliceosome 1/760 145/7206 3.22622154469e-06 ko04925 Aldosterone synthesis and secretion 27/760 105/7206 7.58399053014e-06 ko04072 Phospholipase D signaling pathway 42/760 197/7206 8.66378577085e-06 ko04514 Cell adhesion molecules (CAMs) 31/760 130/7206 9.28627893734e-06 ko04730 Long-term depression 22/760 78/7206 1.07995092993e-05 ko04022 cGMP-PKG signaling pathway 44/760 216/7206 1.39584907599e-05 ko05203 Viral carcinogenesis 10/760 277/7206 2.33083391814e-05 ko03013 RNA transport 4/760 166/7206 0.000100345185717 ko04970 Salivary secretion 23/760 95/7206 0.000121524356685 ko04070 Phosphatidylinositol signaling system 26/760 112/7206 0.000124881978387 ko04060 Cytokine-cytokine receptor interaction 6/760 191/7206 0.000185166767522 ko04930 Type II diabetes mellitus 15/760 54/7206 0.000325054096652 ko05322 Systemic lupus erythematosus 4/760 151/7206 0.000413880310021 ko04360 Axon guidance 42/760 233/7206 0.000456096586931 ko05168 Herpes simplex infection 6/760 182/7206 0.000517652494809 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/760 79/7206 0.000567578220186 ko04260 Cardiac muscle contraction 22/760 98/7206 0.000650236570789 ko04915 Estrogen signaling pathway 27/760 131/7206 0.000756662298754 ko05014 Amyotrophic lateral sclerosis (ALS) 18/760 74/7206 0.000766833136092 ko04621 NOD-like receptor signaling pathway 5/760 157/7206 0.000909354115192 ko04120 Ubiquitin mediated proteolysis 4/760 138/7206 0.00116471841968 ko04740 Olfactory transduction 18/760 80/7206 0.00150358423621 ko04014 Ras signaling pathway 46/760 279/7206 0.00192163203332 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/760 14/7206 0.00192413522569 ko04144 Endocytosis 54/760 342/7206 0.00207405379104 ko05205 Proteoglycans in cancer 14/760 271/7206 0.00231598471576 ko04972 Pancreatic secretion 22/760 111/7206 0.00288011146223 ko04141 Protein processing in endoplasmic reticulum 8/760 184/7206 0.00331259821027 ko04966 Collecting duct acid secretion 8/760 26/7206 0.00408439418678 ko00240 Pyrimidine metabolism 3/760 110/7206 0.00422986887766 ko05414 Dilated cardiomyopathy 22/760 112/7206 0.00449373439833 ko05164 Influenza A 7/760 167/7206 0.00464512191604 ko04745 Phototransduction - fly 10/760 38/7206 0.00486645272679 ko04540 Gap junction 24/760 128/7206 0.00512941550715 ko04971 Gastric acid secretion 19/760 98/7206 0.00745226137658 ko04110 Cell cycle 6/760 145/7206 0.0087605172175 ko04064 NF-kappa B signaling pathway 3/760 96/7206 0.0115639533254 ko04710 Circadian rhythm 10/760 43/7206 0.0121828369225 ko05410 Hypertrophic cardiomyopathy (HCM) 19/760 100/7206 0.0124222144389 ko04640 Hematopoietic cell lineage 1/760 64/7206 0.0125736744647 ko00562 Inositol phosphate metabolism 17/760 89/7206 0.0137946743222 ko04612 Antigen processing and presentation 2/760 77/7206 0.0149928534783 ko05010 Alzheimer's disease 32/760 202/7206 0.0193270861119 ko04924 Renin secretion 16/760 86/7206 0.0207001278818 ko04630 Jak-STAT signaling pathway 6/760 132/7206 0.0211596771554 ko05169 Epstein-Barr virus infection 12/760 206/7206 0.0213100556095 ko05140 Leishmaniasis 2/760 75/7206 0.0215755676182 ko04923 Regulation of lipolysis in adipocytes 15/760 77/7206 0.0226143333137 ko04146 Peroxisome 3/760 89/7206 0.0227026018109 ko05034 Alcoholism 36/760 238/7206 0.0238724052601 ko04750 Inflammatory mediator regulation of TRP channels 21/760 122/7206 0.0242265121125 ko04371 Apelin signaling pathway 28/760 177/7206 0.0254513829095 ko04217 Necroptosis 10/760 178/7206 0.0261076432381 ko00480 Glutathione metabolism 1/760 55/7206 0.0266842143135 ko04062 Chemokine signaling pathway 31/760 201/7206 0.0267377162903 ko04071 Sphingolipid signaling pathway 26/760 162/7206 0.0271601419538 ko04015 Rap1 signaling pathway 41/760 278/7206 0.0277632596736 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/760 59/7206 0.0293068164943 ko05231 Choline metabolism in cancer 22/760 134/7206 0.0323702784361 ko05110 Vibrio cholerae infection 12/760 63/7206 0.0371716825076 ko04973 Carbohydrate digestion and absorption 9/760 42/7206 0.0374499153958 ko00280 Valine, leucine and isoleucine degradation 1/760 54/7206 0.0408875104326 ko05131 Shigellosis 3/760 82/7206 0.04421596837 ko05162 Measles 6/760 120/7206 0.0497857191175