ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 80/832 152/7206 3.15911285067e-36 ko05033 Nicotine addiction 45/832 56/7206 9.37915595711e-33 ko04080 Neuroactive ligand-receptor interaction 136/832 423/7206 7.51871009815e-32 ko05032 Morphine addiction 60/832 110/7206 1.80962229561e-28 ko04727 GABAergic synapse 59/832 110/7206 1.74915397432e-27 ko04723 Retrograde endocannabinoid signaling 71/832 175/7206 2.02099008697e-23 ko04713 Circadian entrainment 61/832 136/7206 5.3966556877e-23 ko04728 Dopaminergic synapse 71/832 185/7206 9.73506193983e-22 ko04725 Cholinergic synapse 60/832 160/7206 6.08718093847e-18 ko04744 Phototransduction 26/832 36/7206 2.39755187408e-17 ko04024 cAMP signaling pathway 81/832 279/7206 4.46976227558e-16 ko04721 Synaptic vesicle cycle 35/832 80/7206 2.70528065627e-13 ko04020 Calcium signaling pathway 73/832 265/7206 4.18019214646e-13 ko04911 Insulin secretion 43/832 117/7206 7.7289696505e-13 ko04726 Serotonergic synapse 46/832 137/7206 5.06915394835e-12 ko04921 Oxytocin signaling pathway 59/832 209/7206 2.45869114856e-11 ko04261 Adrenergic signaling in cardiomyocytes 58/832 205/7206 3.47272684293e-11 ko04720 Long-term potentiation 36/832 99/7206 8.37727202712e-11 ko04742 Taste transduction 27/832 61/7206 1.07468488936e-10 ko05031 Amphetamine addiction 34/832 91/7206 1.20011557203e-10 ko05030 Cocaine addiction 26/832 73/7206 5.90954571825e-08 ko04970 Salivary secretion 30/832 95/7206 1.30008517879e-07 ko04925 Aldosterone synthesis and secretion 31/832 105/7206 4.36570158348e-07 ko03040 Spliceosome 1/832 145/7206 5.43274954979e-07 ko04022 cGMP-PKG signaling pathway 50/832 216/7206 1.16753160735e-06 ko04010 MAPK signaling pathway 66/832 321/7206 1.71308820876e-06 ko04740 Olfactory transduction 25/832 80/7206 1.80219764453e-06 ko05203 Viral carcinogenesis 10/832 277/7206 3.05357310069e-06 ko04514 Cell adhesion molecules (CAMs) 33/832 130/7206 9.47576668396e-06 ko04072 Phospholipase D signaling pathway 44/832 197/7206 1.23370937802e-05 ko03013 RNA transport 4/832 166/7206 2.18752007053e-05 ko04971 Gastric acid secretion 26/832 98/7206 3.61203242067e-05 ko04730 Long-term depression 22/832 78/7206 4.50219362243e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 21/832 74/7206 6.04846886128e-05 ko04260 Cardiac muscle contraction 25/832 98/7206 9.29254981289e-05 ko05164 Influenza A 5/832 167/7206 0.000112655041459 ko04972 Pancreatic secretion 27/832 111/7206 0.000128864822856 ko05322 Systemic lupus erythematosus 4/832 151/7206 0.000141663415569 ko04070 Phosphatidylinositol signaling system 27/832 112/7206 0.000146684234532 ko04060 Cytokine-cytokine receptor interaction 7/832 191/7206 0.000194823198308 ko04745 Phototransduction - fly 13/832 38/7206 0.000201454597222 ko04360 Axon guidance 46/832 233/7206 0.000226974585162 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/832 79/7206 0.000227784487168 ko04621 NOD-like receptor signaling pathway 5/832 157/7206 0.000325260828512 ko05168 Herpes simplex infection 7/832 182/7206 0.000360992525988 ko04120 Ubiquitin mediated proteolysis 4/832 138/7206 0.000389145120618 ko04915 Estrogen signaling pathway 29/832 131/7206 0.000457013748665 ko04110 Cell cycle 5/832 145/7206 0.000874767490913 ko05205 Proteoglycans in cancer 15/832 271/7206 0.000908824072592 ko04141 Protein processing in endoplasmic reticulum 8/832 184/7206 0.000948650743098 ko05169 Epstein-Barr virus infection 10/832 206/7206 0.00121998856779 ko04612 Antigen processing and presentation 1/832 77/7206 0.00176879135691 ko04924 Renin secretion 20/832 86/7206 0.00182899204639 ko04630 Jak-STAT signaling pathway 5/832 132/7206 0.00233325109179 ko05414 Dilated cardiomyopathy 24/832 112/7206 0.00246045299509 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/832 14/7206 0.00307987849308 ko04964 Proximal tubule bicarbonate reclamation 9/832 29/7206 0.00410676285038 ko04640 Hematopoietic cell lineage 1/832 64/7206 0.00553118666476 ko04064 NF-kappa B signaling pathway 3/832 96/7206 0.00564167382227 ko00562 Inositol phosphate metabolism 19/832 89/7206 0.00684488178985 ko04014 Ras signaling pathway 47/832 279/7206 0.00719192190216 ko05034 Alcoholism 41/832 238/7206 0.00724678368566 ko04540 Gap junction 25/832 128/7206 0.00746658197379 ko00330 Arginine and proline metabolism 1/832 61/7206 0.00814884730871 ko04930 Type II diabetes mellitus 13/832 54/7206 0.0084694252731 ko05162 Measles 5/832 120/7206 0.00867981666155 ko04750 Inflammatory mediator regulation of TRP channels 24/832 122/7206 0.00919652619231 ko05140 Leishmaniasis 2/832 75/7206 0.0101215540678 ko04146 Peroxisome 3/832 89/7206 0.0112658673297 ko05161 Hepatitis B 10/832 173/7206 0.0152983946206 ko04371 Apelin signaling pathway 31/832 177/7206 0.0166442938059 ko04923 Regulation of lipolysis in adipocytes 16/832 77/7206 0.0180084451344 ko05131 Shigellosis 3/832 82/7206 0.0222240312737 ko04062 Chemokine signaling pathway 34/832 201/7206 0.0243129036019 ko04973 Carbohydrate digestion and absorption 10/832 42/7206 0.0244404831857 ko04710 Circadian rhythm 10/832 43/7206 0.0270161513261 ko04670 Leukocyte transendothelial migration 9/832 151/7206 0.0280708303824 ko04510 Focal adhesion 17/832 240/7206 0.0302314685518 ko05130 Pathogenic Escherichia coli infection 3/832 77/7206 0.030576822292 ko04976 Bile secretion 16/832 80/7206 0.032161809836 ko04932 Non-alcoholic fatty liver disease (NAFLD) 12/832 182/7206 0.033832536949 ko00270 Cysteine and methionine metabolism 1/832 47/7206 0.0379768119599 ko04810 Regulation of actin cytoskeleton 20/832 264/7206 0.0391066637242 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/832 59/7206 0.0408201138269 ko04657 IL-17 signaling pathway 4/832 87/7206 0.0413904883695 ko05010 Alzheimer's disease 33/832 202/7206 0.0433599030184 ko04960 Aldosterone-regulated sodium reabsorption 9/832 41/7206 0.0473265756773 ko04550 Signaling pathways regulating pluripotency of stem cells 11/832 165/7206 0.0480564009635 ko04626 Plant-pathogen interaction 5/832 18/7206 0.0482742738027 ko00240 Pyrimidine metabolism 6/832 110/7206 0.0488818994698