ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 7/387 20/7206 5.14305348255e-05 ko04710 Circadian rhythm 9/387 43/7206 0.00037403342977 ko04137 Mitophagy - animal 13/387 82/7206 0.000381908073083 ko04380 Osteoclast differentiation 17/387 134/7206 0.000778843652699 ko00051 Fructose and mannose metabolism 8/387 42/7206 0.00151690089423 ko04621 NOD-like receptor signaling pathway 18/387 157/7206 0.0019624923343 ko04922 Glucagon signaling pathway 16/387 128/7206 0.00209499490752 ko04070 Phosphatidylinositol signaling system 14/387 112/7206 0.00255425899389 ko04610 Complement and coagulation cascades 11/387 79/7206 0.00310361541148 ko04022 cGMP-PKG signaling pathway 22/387 216/7206 0.0032653572497 ko05230 Central carbon metabolism in cancer 11/387 81/7206 0.00378300687164 ko05164 Influenza A 18/387 167/7206 0.00452378138293 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/387 191/7206 0.00475296998379 ko03040 Spliceosome 1/387 145/7206 0.00477517090128 ko04110 Cell cycle 1/387 145/7206 0.00477517090128 ko04650 Natural killer cell mediated cytotoxicity 12/387 97/7206 0.0055050989121 ko00140 Steroid hormone biosynthesis 7/387 41/7206 0.00562091218018 ko04725 Cholinergic synapse 17/387 160/7206 0.00664548159079 ko00350 Tyrosine metabolism 6/387 33/7206 0.00743100262727 ko05145 Toxoplasmosis 14/387 126/7206 0.00831613801298 ko04060 Cytokine-cytokine receptor interaction 19/387 191/7206 0.00841002571414 ko00360 Phenylalanine metabolism 4/387 17/7206 0.011156162461 ko04966 Collecting duct acid secretion 5/387 26/7206 0.011235377719 ko04921 Oxytocin signaling pathway 20/387 209/7206 0.0115528495563 ko03013 RNA transport 2/387 166/7206 0.0129573933232 ko04925 Aldosterone synthesis and secretion 12/387 105/7206 0.0131736191085 ko05152 Tuberculosis 18/387 187/7206 0.0134205724316 ko04626 Plant-pathogen interaction 4/387 18/7206 0.0137480800735 ko00950 Isoquinoline alkaloid biosynthesis 3/387 10/7206 0.0139001452703 ko04745 Phototransduction - fly 6/387 38/7206 0.0147882324756 ko03010 Ribosome 1/387 129/7206 0.0154844058554 ko00592 alpha-Linolenic acid metabolism 4/387 19/7206 0.016692654256 ko00010 Glycolysis / Gluconeogenesis 9/387 74/7206 0.0169540349743 ko04622 RIG-I-like receptor signaling pathway 8/387 62/7206 0.0171044175694 ko04371 Apelin signaling pathway 17/387 177/7206 0.0172154396305 ko04064 NF-kappa B signaling pathway 11/387 96/7206 0.0182599553679 ko04971 Gastric acid secretion 11/387 98/7206 0.0198371689088 ko00590 Arachidonic acid metabolism 7/387 52/7206 0.0202122648734 ko05340 Primary immunodeficiency 5/387 30/7206 0.0204277789054 ko04960 Aldosterone-regulated sodium reabsorption 6/387 41/7206 0.0210567341559 ko04066 HIF-1 signaling pathway 13/387 123/7206 0.0230134154572 ko04930 Type II diabetes mellitus 7/387 54/7206 0.024429866822 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/387 5/7206 0.025817918378 ko05321 Inflammatory bowel disease (IBD) 7/387 56/7206 0.029215478056 ko04711 Circadian rhythm - fly 3/387 13/7206 0.0293926398844 ko05031 Amphetamine addiction 10/387 91/7206 0.0298497431837 ko00052 Galactose metabolism 5/387 33/7206 0.0298535168621 ko04144 Endocytosis 10/387 342/7206 0.0364977563761 ko04668 TNF signaling pathway 12/387 120/7206 0.0370344219166 ko00220 Arginine biosynthesis 4/387 24/7206 0.0370854344801 ko00362 Benzoate degradation 2/387 6/7206 0.0373659389082 ko04750 Inflammatory mediator regulation of TRP channels 12/387 122/7206 0.0393459602957 ko05150 Staphylococcus aureus infection 5/387 36/7206 0.0416384002084 ko00564 Glycerophospholipid metabolism 10/387 99/7206 0.0431909309624 ko05160 Hepatitis C 14/387 153/7206 0.0446420198587 ko04270 Vascular smooth muscle contraction 14/387 154/7206 0.0459258090324 ko04672 Intestinal immune network for IgA production 5/387 37/7206 0.0461091874954 ko04924 Renin secretion 9/387 86/7206 0.0487948341329 ko00380 Tryptophan metabolism 6/387 50/7206 0.0498823315248