ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1086	423/7206	3.78411621457e-56
ko05033	Nicotine addiction	49/1086	56/7206	1.66681332127e-33
ko04724	Glutamatergic synapse	86/1086	152/7206	5.43316247653e-33
ko04713	Circadian entrainment	79/1086	136/7206	1.85205429317e-31
ko04727	GABAergic synapse	65/1086	110/7206	1.22939458131e-26
ko05032	Morphine addiction	64/1086	110/7206	1.03782621866e-25
ko04728	Dopaminergic synapse	84/1086	185/7206	1.80634348206e-23
ko04721	Synaptic vesicle cycle	50/1086	80/7206	2.72097298019e-22
ko04725	Cholinergic synapse	74/1086	160/7206	2.23385780641e-21
ko04723	Retrograde endocannabinoid signaling	77/1086	175/7206	1.47232336582e-20
ko04020	Calcium signaling pathway	97/1086	265/7206	1.09501148338e-18
ko04911	Insulin secretion	57/1086	117/7206	4.86201851736e-18
ko04024	cAMP signaling pathway	98/1086	279/7206	2.63893727193e-17
ko04921	Oxytocin signaling pathway	79/1086	209/7206	2.44403644585e-16
ko04742	Taste transduction	37/1086	61/7206	3.41668409113e-16
ko04726	Serotonergic synapse	59/1086	137/7206	1.74617469671e-15
ko04740	Olfactory transduction	42/1086	80/7206	4.3404740198e-15
ko04720	Long-term potentiation	47/1086	99/7206	1.52399185594e-14
ko05031	Amphetamine addiction	44/1086	91/7206	4.67419917331e-14
ko04970	Salivary secretion	44/1086	95/7206	3.21930730645e-13
ko04261	Adrenergic signaling in cardiomyocytes	69/1086	205/7206	1.41382387644e-11
ko04925	Aldosterone synthesis and secretion	43/1086	105/7206	9.23451088165e-11
ko04744	Phototransduction	22/1086	36/7206	3.10278574051e-10
ko04971	Gastric acid secretion	40/1086	98/7206	4.74582463973e-10
ko03040	Spliceosome	1/1086	145/7206	2.23049589863e-09
ko05203	Viral carcinogenesis	12/1086	277/7206	9.59866264867e-09
ko05168	Herpes simplex infection	4/1086	182/7206	1.05526459997e-08
ko05030	Cocaine addiction	30/1086	73/7206	5.96585769795e-08
ko04745	Phototransduction - fly	19/1086	38/7206	4.20540241088e-07
ko04060	Cytokine-cytokine receptor interaction	7/1086	191/7206	5.21424306194e-07
ko04260	Cardiac muscle contraction	34/1086	98/7206	1.0915697622e-06
ko04540	Gap junction	41/1086	128/7206	1.09240162888e-06
ko04730	Long-term depression	29/1086	78/7206	1.22796937508e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1086	74/7206	4.33220395519e-06
ko04010	MAPK signaling pathway	79/1086	321/7206	4.48387713584e-06
ko05322	Systemic lupus erythematosus	5/1086	151/7206	4.65414432135e-06
ko04966	Collecting duct acid secretion	14/1086	26/7206	4.6773483805e-06
ko04750	Inflammatory mediator regulation of TRP channels	38/1086	122/7206	5.25234101683e-06
ko04022	cGMP-PKG signaling pathway	58/1086	216/7206	6.58792441379e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1086	79/7206	7.85668792681e-06
ko05164	Influenza A	7/1086	167/7206	9.0332059131e-06
ko04360	Axon guidance	61/1086	233/7206	9.34981097818e-06
ko04972	Pancreatic secretion	35/1086	111/7206	1.08251324946e-05
ko04924	Renin secretion	29/1086	86/7206	1.23593436454e-05
ko03013	RNA transport	7/1086	166/7206	1.32888009335e-05
ko05169	Epstein-Barr virus infection	11/1086	206/7206	1.67736900781e-05
ko04120	Ubiquitin mediated proteolysis	5/1086	138/7206	1.96255122694e-05
ko05110	Vibrio cholerae infection	23/1086	63/7206	2.17988007064e-05
ko04621	NOD-like receptor signaling pathway	7/1086	157/7206	3.72241557279e-05
ko04141	Protein processing in endoplasmic reticulum	10/1086	184/7206	5.98804243375e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1086	59/7206	7.59246550329e-05
ko04626	Plant-pathogen interaction	10/1086	18/7206	7.97690497392e-05
ko04514	Cell adhesion molecules (CAMs)	37/1086	130/7206	9.27899299104e-05
ko04976	Bile secretion	25/1086	80/7206	0.000216174656576
ko04014	Ras signaling pathway	65/1086	279/7206	0.000219744215483
ko05414	Dilated cardiomyopathy	32/1086	112/7206	0.000247625103257
ko05162	Measles	5/1086	120/7206	0.000249046916035
ko04912	GnRH signaling pathway	34/1086	122/7206	0.000275828083396
ko04915	Estrogen signaling pathway	36/1086	131/7206	0.00028115999112
ko03008	Ribosome biogenesis in eukaryotes	2/1086	79/7206	0.000412875403434
ko04070	Phosphatidylinositol signaling system	31/1086	112/7206	0.00047200150897
ko04072	Phospholipase D signaling pathway	48/1086	197/7206	0.000533264088378
ko04964	Proximal tubule bicarbonate reclamation	12/1086	29/7206	0.000554980541226
ko04110	Cell cycle	8/1086	145/7206	0.000573563933489
ko04330	Notch signaling pathway	1/1086	62/7206	0.000967345724382
ko04214	Apoptosis - fly	2/1086	72/7206	0.00133389324269
ko05166	HTLV-I infection	26/1086	292/7206	0.00192112022534
ko04371	Apelin signaling pathway	42/1086	177/7206	0.00193990923032
ko00520	Amino sugar and nucleotide sugar metabolism	1/1086	55/7206	0.0020957181031
ko04610	Complement and coagulation cascades	3/1086	79/7206	0.00232871618893
ko04146	Peroxisome	4/1086	89/7206	0.00258085942352
ko04612	Antigen processing and presentation	3/1086	77/7206	0.00339471046531
ko04064	NF-kappa B signaling pathway	5/1086	96/7206	0.0037973194834
ko04916	Melanogenesis	34/1086	142/7206	0.00435884598593
ko00310	Lysine degradation	3/1086	73/7206	0.0047833010464
ko05140	Leishmaniasis	3/1086	75/7206	0.00499816653244
ko04350	TGF-beta signaling pathway	6/1086	103/7206	0.00526567958072
ko05214	Glioma	21/1086	79/7206	0.00677233889766
ko00240	Pyrimidine metabolism	7/1086	110/7206	0.00697581205896
ko05161	Hepatitis B	14/1086	173/7206	0.00703463408246
ko05205	Proteoglycans in cancer	26/1086	271/7206	0.00919728842217
ko04657	IL-17 signaling pathway	5/1086	87/7206	0.010139717567
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1086	100/7206	0.0103758419699
ko04217	Necroptosis	15/1086	178/7206	0.0105503964156
ko05144	Malaria	1/1086	45/7206	0.0105937815187
ko00071	Fatty acid degradation	1/1086	45/7206	0.0105937815187
ko03420	Nucleotide excision repair	1/1086	46/7206	0.0110264433527
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1086	14/7206	0.0117144534185
ko00480	Glutathione metabolism	2/1086	55/7206	0.0127715966819
ko04015	Rap1 signaling pathway	57/1086	278/7206	0.0129061405635
ko05321	Inflammatory bowel disease (IBD)	2/1086	56/7206	0.0130957050502
ko04978	Mineral absorption	12/1086	40/7206	0.0136108224762
ko04658	Th1 and Th2 cell differentiation	6/1086	96/7206	0.0136705004608
ko04640	Hematopoietic cell lineage	3/1086	64/7206	0.0138453521466
ko03018	RNA degradation	5/1086	84/7206	0.0139703803244
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1086	182/7206	0.0153680713387
ko05131	Shigellosis	5/1086	82/7206	0.0191539843038
ko04622	RIG-I-like receptor signaling pathway	3/1086	62/7206	0.0195601978307
ko04668	TNF signaling pathway	9/1086	120/7206	0.0196239762224
ko04270	Vascular smooth muscle contraction	34/1086	154/7206	0.0219728813052
ko05145	Toxoplasmosis	10/1086	126/7206	0.0230402751327
ko04923	Regulation of lipolysis in adipocytes	19/1086	77/7206	0.0241072921536
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1086	92/7206	0.0263271635366
ko04630	Jak-STAT signaling pathway	11/1086	132/7206	0.0267819090458
ko04973	Carbohydrate digestion and absorption	12/1086	42/7206	0.0268422231495
ko05010	Alzheimer's disease	42/1086	202/7206	0.0276005643426
ko00330	Arginine and proline metabolism	3/1086	61/7206	0.0286640119582
ko04722	Neurotrophin signaling pathway	34/1086	160/7206	0.0331867664381
ko05034	Alcoholism	48/1086	238/7206	0.0334864865455
ko04930	Type II diabetes mellitus	14/1086	54/7206	0.0340808281352
ko04922	Glucagon signaling pathway	28/1086	128/7206	0.0341171577078
ko04210	Apoptosis	17/1086	180/7206	0.0342097643207
ko01524	Platinum drug resistance	5/1086	76/7206	0.035518814929
ko03410	Base excision repair	1/1086	38/7206	0.0364581334792
ko00620	Pyruvate metabolism	2/1086	46/7206	0.0380477915183
ko00260	Glycine, serine and threonine metabolism	2/1086	48/7206	0.0396181383539
ko05215	Prostate cancer	9/1086	111/7206	0.0435946614502
ko05212	Pancreatic cancer	6/1086	83/7206	0.0442595290058
ko01200	Carbon metabolism	11/1086	128/7206	0.044868688807
ko04960	Aldosterone-regulated sodium reabsorption	11/1086	41/7206	0.0462446168318
ko04918	Thyroid hormone synthesis	20/1086	86/7206	0.0467368971327
ko04620	Toll-like receptor signaling pathway	8/1086	100/7206	0.0480372396221
ko04115	p53 signaling pathway	5/1086	74/7206	0.0483965807394