ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1167	423/7206	3.17063486387e-52
ko04724	Glutamatergic synapse	88/1167	152/7206	2.57081311794e-32
ko05033	Nicotine addiction	48/1167	56/7206	1.85106788214e-30
ko05032	Morphine addiction	68/1167	110/7206	1.44999772254e-27
ko04713	Circadian entrainment	76/1167	136/7206	1.2236885745e-26
ko04727	GABAergic synapse	67/1167	110/7206	1.25635673846e-26
ko04721	Synaptic vesicle cycle	55/1167	80/7206	6.35615461845e-26
ko04728	Dopaminergic synapse	86/1167	185/7206	1.1490454414e-22
ko04725	Cholinergic synapse	78/1167	160/7206	2.89760360491e-22
ko04024	cAMP signaling pathway	106/1167	279/7206	2.4262945577e-19
ko04723	Retrograde endocannabinoid signaling	77/1167	175/7206	1.25307701736e-18
ko04911	Insulin secretion	59/1167	117/7206	5.22149543419e-18
ko04020	Calcium signaling pathway	98/1167	265/7206	5.30430960679e-17
ko04744	Phototransduction	28/1167	36/7206	4.4345163445e-16
ko04726	Serotonergic synapse	62/1167	137/7206	6.16109384985e-16
ko04742	Taste transduction	37/1167	61/7206	3.75037352481e-15
ko04921	Oxytocin signaling pathway	79/1167	209/7206	1.80572724066e-14
ko04740	Olfactory transduction	42/1167	80/7206	5.76328125154e-14
ko04720	Long-term potentiation	46/1167	99/7206	1.17223959052e-12
ko05031	Amphetamine addiction	43/1167	91/7206	3.16696262366e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1167	205/7206	1.66524599182e-11
ko04970	Salivary secretion	43/1167	95/7206	1.91220146691e-11
ko03040	Spliceosome	1/1167	145/7206	3.17197686327e-10
ko04925	Aldosterone synthesis and secretion	43/1167	105/7206	9.6944390296e-10
ko04971	Gastric acid secretion	41/1167	98/7206	1.10411874584e-09
ko05203	Viral carcinogenesis	13/1167	277/7206	3.13463081364e-09
ko04966	Collecting duct acid secretion	17/1167	26/7206	2.35818106833e-08
ko04360	Axon guidance	71/1167	233/7206	3.34177930965e-08
ko05168	Herpes simplex infection	6/1167	182/7206	3.6394778391e-08
ko04060	Cytokine-cytokine receptor interaction	8/1167	191/7206	2.50197668492e-07
ko05030	Cocaine addiction	30/1167	73/7206	3.0740981051e-07
ko04972	Pancreatic secretion	40/1167	111/7206	3.08534488743e-07
ko04924	Renin secretion	33/1167	86/7206	7.64607889313e-07
ko04022	cGMP-PKG signaling pathway	63/1167	216/7206	1.20911827016e-06
ko03013	RNA transport	7/1167	166/7206	1.89871881603e-06
ko04010	MAPK signaling pathway	84/1167	321/7206	2.83316695754e-06
ko05322	Systemic lupus erythematosus	6/1167	151/7206	3.34112331249e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1167	59/7206	5.7914720823e-06
ko04120	Ubiquitin mediated proteolysis	5/1167	138/7206	5.93025041668e-06
ko04730	Long-term depression	29/1167	78/7206	6.41373404459e-06
ko04745	Phototransduction - fly	18/1167	38/7206	6.70955955603e-06
ko05164	Influenza A	8/1167	167/7206	9.33827034452e-06
ko04141	Protein processing in endoplasmic reticulum	10/1167	184/7206	1.02686918351e-05
ko04014	Ras signaling pathway	73/1167	279/7206	1.40362812856e-05
ko04540	Gap junction	40/1167	128/7206	1.71509241235e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1167	74/7206	1.90426097223e-05
ko04621	NOD-like receptor signaling pathway	8/1167	157/7206	2.53961600335e-05
ko04514	Cell adhesion molecules (CAMs)	40/1167	130/7206	3.11862241293e-05
ko04612	Antigen processing and presentation	1/1167	77/7206	3.12382397781e-05
ko04976	Bile secretion	28/1167	80/7206	4.03627095463e-05
ko04260	Cardiac muscle contraction	32/1167	98/7206	4.53961896987e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1167	29/7206	5.52543112182e-05
ko05169	Epstein-Barr virus infection	14/1167	206/7206	7.09807802836e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1167	79/7206	7.82476205039e-05
ko05110	Vibrio cholerae infection	23/1167	63/7206	8.42541307465e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1167	122/7206	9.07933796024e-05
ko04110	Cell cycle	8/1167	145/7206	0.000140057759929
ko04070	Phosphatidylinositol signaling system	34/1167	112/7206	0.000145832364919
ko04626	Plant-pathogen interaction	10/1167	18/7206	0.000149479770811
ko03008	Ribosome biogenesis in eukaryotes	2/1167	79/7206	0.00017243001153
ko04072	Phospholipase D signaling pathway	51/1167	197/7206	0.000386109612861
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1167	14/7206	0.00055403162524
ko00240	Pyrimidine metabolism	6/1167	110/7206	0.000968127975135
ko05162	Measles	7/1167	120/7206	0.00100229328025
ko05414	Dilated cardiomyopathy	32/1167	112/7206	0.00103752987771
ko04915	Estrogen signaling pathway	36/1167	131/7206	0.00106884720632
ko04146	Peroxisome	4/1167	89/7206	0.0012118139924
ko00520	Amino sugar and nucleotide sugar metabolism	1/1167	55/7206	0.0013388907965
ko00480	Glutathione metabolism	1/1167	55/7206	0.0013388907965
ko04064	NF-kappa B signaling pathway	5/1167	96/7206	0.00185800953873
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1167	182/7206	0.00211061398049
ko00310	Lysine degradation	3/1167	73/7206	0.00218455356071
ko05140	Leishmaniasis	3/1167	75/7206	0.00227990581718
ko05166	HTLV-I infection	29/1167	292/7206	0.0025793333306
ko04371	Apelin signaling pathway	44/1167	177/7206	0.00259429050071
ko04912	GnRH signaling pathway	33/1167	122/7206	0.00262419719243
ko00330	Arginine and proline metabolism	2/1167	61/7206	0.00266488479535
ko04330	Notch signaling pathway	2/1167	62/7206	0.00270159098995
ko04214	Apoptosis - fly	3/1167	72/7206	0.00323161917724
ko05205	Proteoglycans in cancer	27/1167	271/7206	0.00409938016225
ko03420	Nucleotide excision repair	1/1167	46/7206	0.00445042948444
ko05161	Hepatitis B	15/1167	173/7206	0.00468047200056
ko04610	Complement and coagulation cascades	4/1167	79/7206	0.00502049226032
ko03022	Basal transcription factors	1/1167	44/7206	0.00668557271501
ko05144	Malaria	1/1167	45/7206	0.00688747142316
ko00071	Fatty acid degradation	1/1167	45/7206	0.00688747142316
ko03018	RNA degradation	5/1167	84/7206	0.00697639584549
ko04923	Regulation of lipolysis in adipocytes	22/1167	77/7206	0.00726440339973
ko04015	Rap1 signaling pathway	61/1167	278/7206	0.00995833030005
ko04270	Vascular smooth muscle contraction	37/1167	154/7206	0.0106663234778
ko05231	Choline metabolism in cancer	33/1167	134/7206	0.0122728385395
ko00590	Arachidonic acid metabolism	2/1167	52/7206	0.0124617496323
ko04217	Necroptosis	17/1167	178/7206	0.0131372968965
ko04622	RIG-I-like receptor signaling pathway	3/1167	62/7206	0.0137905904862
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1167	92/7206	0.0146008843634
ko04916	Melanogenesis	34/1167	142/7206	0.0152743134445
ko04350	TGF-beta signaling pathway	8/1167	103/7206	0.0152933264533
ko04658	Th1 and Th2 cell differentiation	7/1167	96/7206	0.0167389734577
ko00260	Glycine, serine and threonine metabolism	2/1167	48/7206	0.0176608897392
ko04657	IL-17 signaling pathway	6/1167	87/7206	0.0179554402851
ko04973	Carbohydrate digestion and absorption	13/1167	42/7206	0.0180288006653
ko01524	Platinum drug resistance	5/1167	76/7206	0.0183949613283
ko00562	Inositol phosphate metabolism	23/1167	89/7206	0.0194352382402
ko04062	Chemokine signaling pathway	45/1167	201/7206	0.0194811238758
ko05214	Glioma	21/1167	79/7206	0.0197981654774
ko05145	Toxoplasmosis	11/1167	126/7206	0.019983585989
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1167	100/7206	0.0200440261493
ko05418	Fluid shear stress and atherosclerosis	17/1167	173/7206	0.0210655777237
ko04071	Sphingolipid signaling pathway	37/1167	162/7206	0.0235026173224
ko05131	Shigellosis	6/1167	82/7206	0.0237635249631
ko00630	Glyoxylate and dicarboxylate metabolism	1/1167	38/7206	0.0238173880781
ko03410	Base excision repair	1/1167	38/7206	0.0238173880781
ko00910	Nitrogen metabolism	7/1167	19/7206	0.0241129065909
ko04115	p53 signaling pathway	5/1167	74/7206	0.0253137131763
ko04640	Hematopoietic cell lineage	4/1167	64/7206	0.0262580293941
ko05321	Inflammatory bowel disease (IBD)	3/1167	56/7206	0.0269812766644
ko04978	Mineral absorption	12/1167	40/7206	0.0282695440443
ko04668	TNF signaling pathway	11/1167	120/7206	0.0334042096698
ko05215	Prostate cancer	10/1167	111/7206	0.0374045203356
ko04722	Neurotrophin signaling pathway	36/1167	160/7206	0.0383431605114
ko01200	Carbon metabolism	12/1167	128/7206	0.0385695129881
ko05133	Pertussis	7/1167	87/7206	0.0393296905998
ko04210	Apoptosis	19/1167	180/7206	0.0398579682565
ko05217	Basal cell carcinoma	5/1167	68/7206	0.046647381021
ko03015	mRNA surveillance pathway	8/1167	93/7206	0.0466565335505
ko05016	Huntington's disease	24/1167	215/7206	0.0477617066956