ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 34/292 191/7206 1.28614873463e-13 ko05340 Primary immunodeficiency 14/292 30/7206 1.91882712276e-12 ko04650 Natural killer cell mediated cytotoxicity 23/292 97/7206 3.01627533617e-12 ko05162 Measles 23/292 120/7206 3.09867758834e-10 ko05164 Influenza A 27/292 167/7206 4.84081400785e-10 ko05140 Leishmaniasis 18/292 75/7206 6.09366350577e-10 ko05330 Allograft rejection 11/292 24/7206 6.26185612929e-10 ko04612 Antigen processing and presentation 18/292 77/7206 9.68113509519e-10 ko05145 Toxoplasmosis 22/292 126/7206 4.83102996054e-09 ko04659 Th17 cell differentiation 20/292 106/7206 6.18654054147e-09 ko05320 Autoimmune thyroid disease 11/292 29/7206 7.23572650001e-09 ko05332 Graft-versus-host disease 9/292 18/7206 9.19226933395e-09 ko05152 Tuberculosis 26/292 187/7206 2.73201761607e-08 ko05168 Herpes simplex infection 25/292 182/7206 6.54361595434e-08 ko04380 Osteoclast differentiation 21/292 134/7206 7.81256309689e-08 ko04672 Intestinal immune network for IgA production 11/292 37/7206 1.33704394994e-07 ko05321 Inflammatory bowel disease (IBD) 13/292 56/7206 2.39599326484e-07 ko04621 NOD-like receptor signaling pathway 22/292 157/7206 2.92055127808e-07 ko04620 Toll-like receptor signaling pathway 17/292 100/7206 4.25678301782e-07 ko04062 Chemokine signaling pathway 25/292 201/7206 4.61757596458e-07 ko04658 Th1 and Th2 cell differentiation 16/292 96/7206 1.23552991069e-06 ko04660 T cell receptor signaling pathway 18/292 124/7206 2.15429810328e-06 ko04940 Type I diabetes mellitus 9/292 32/7206 3.20890474436e-06 ko04630 Jak-STAT signaling pathway 18/292 132/7206 5.37051570438e-06 ko04217 Necroptosis 21/292 178/7206 9.19378290416e-06 ko05150 Staphylococcus aureus infection 9/292 36/7206 9.33393600371e-06 ko04145 Phagosome 19/292 162/7206 2.68913217239e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/292 191/7206 2.72959378692e-05 ko04064 NF-kappa B signaling pathway 14/292 96/7206 2.81390779533e-05 ko04622 RIG-I-like receptor signaling pathway 11/292 62/7206 3.21308031406e-05 ko05310 Asthma 6/292 17/7206 3.5662172151e-05 ko04640 Hematopoietic cell lineage 11/292 64/7206 4.37301952559e-05 ko03050 Proteasome 10/292 54/7206 5.02155958819e-05 ko05144 Malaria 9/292 45/7206 6.3709568309e-05 ko05133 Pertussis 12/292 87/7206 0.000181739823676 ko04623 Cytosolic DNA-sensing pathway 8/292 41/7206 0.000196229924217 ko05161 Hepatitis B 18/292 173/7206 0.000208773285563 ko05142 Chagas disease (American trypanosomiasis) 14/292 130/7206 0.000744845292335 ko04662 B cell receptor signaling pathway 11/292 88/7206 0.000792996692553 ko05323 Rheumatoid arthritis 11/292 89/7206 0.000872922611537 ko04666 Fc gamma R-mediated phagocytosis 13/292 122/7206 0.0012616946448 ko05416 Viral myocarditis 8/292 55/7206 0.00152891640431 ko04514 Cell adhesion molecules (CAMs) 13/292 130/7206 0.00225049767333 ko04664 Fc epsilon RI signaling pathway 9/292 77/7206 0.00373079794397 ko00590 Arachidonic acid metabolism 7/292 52/7206 0.00466488724249 ko04137 Mitophagy - animal 9/292 82/7206 0.00568433020941 ko04360 Axon guidance 2/292 233/7206 0.00626216753592 ko05034 Alcoholism 2/292 238/7206 0.00645242662697 ko04728 Dopaminergic synapse 1/292 185/7206 0.00718951979057 ko04611 Platelet activation 14/292 163/7206 0.00731267273598 ko00120 Primary bile acid biosynthesis 4/292 20/7206 0.00765205706085 ko05160 Hepatitis C 13/292 153/7206 0.0106591613586 ko04310 Wnt signaling pathway 1/292 181/7206 0.0110257825424 ko04610 Complement and coagulation cascades 8/292 79/7206 0.0142127915843 ko00511 Other glycan degradation 4/292 26/7206 0.0195236998987 ko00980 Metabolism of xenobiotics by cytochrome P450 5/292 40/7206 0.0217425674901 ko04530 Tight junction 3/292 228/7206 0.0261062666523 ko05169 Epstein-Barr virus infection 15/292 206/7206 0.0285923146504 ko03040 Spliceosome 1/292 145/7206 0.0313316747078 ko04136 Autophagy - other 4/292 31/7206 0.0351181867759 ko04390 Hippo signaling pathway 2/292 188/7206 0.0360933323179 ko05143 African trypanosomiasis 4/292 32/7206 0.0388997319165 ko05204 Chemical carcinogenesis 5/292 48/7206 0.0436461894926 ko05224 Breast cancer 2/292 174/7206 0.0491853787349 ko04723 Retrograde endocannabinoid signaling 2/292 175/7206 0.0494127721274