ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 50/612 191/7206 1.57324585883e-13 ko04380 Osteoclast differentiation 37/612 134/7206 4.71665872734e-11 ko04621 NOD-like receptor signaling pathway 40/612 157/7206 1.15838694475e-10 ko05164 Influenza A 39/612 167/7206 3.08531603342e-09 ko05340 Primary immunodeficiency 14/612 30/7206 3.5456324717e-08 ko00120 Primary bile acid biosynthesis 11/612 20/7206 1.25354964522e-07 ko05162 Measles 29/612 120/7206 1.53909254463e-07 ko04064 NF-kappa B signaling pathway 25/612 96/7206 2.40975604987e-07 ko04610 Complement and coagulation cascades 22/612 79/7206 3.61637104505e-07 ko05321 Inflammatory bowel disease (IBD) 18/612 56/7206 4.0516125597e-07 ko04620 Toll-like receptor signaling pathway 25/612 100/7206 5.60738711202e-07 ko05140 Leishmaniasis 21/612 75/7206 6.04122153793e-07 ko04650 Natural killer cell mediated cytotoxicity 24/612 97/7206 1.15703831167e-06 ko04658 Th1 and Th2 cell differentiation 23/612 96/7206 3.5069606165e-06 ko05168 Herpes simplex infection 35/612 182/7206 4.39023319819e-06 ko04659 Th17 cell differentiation 24/612 106/7206 6.22370242367e-06 ko04217 Necroptosis 33/612 178/7206 1.48195354089e-05 ko05145 Toxoplasmosis 26/612 126/7206 1.54260353247e-05 ko04630 Jak-STAT signaling pathway 27/612 132/7206 1.98652083366e-05 ko05150 Staphylococcus aureus infection 12/612 36/7206 2.35566921892e-05 ko05133 Pertussis 20/612 87/7206 2.90165610281e-05 ko04660 T cell receptor signaling pathway 25/612 124/7206 4.89974228756e-05 ko03040 Spliceosome 1/612 145/7206 6.00145296677e-05 ko04668 TNF signaling pathway 24/612 120/7206 7.72627998116e-05 ko03013 RNA transport 2/612 166/7206 9.92099860281e-05 ko04662 B cell receptor signaling pathway 19/612 88/7206 0.000113400452716 ko05161 Hepatitis B 30/612 173/7206 0.000141718839973 ko04672 Intestinal immune network for IgA production 11/612 37/7206 0.000166772836395 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/612 191/7206 0.000174774314623 ko04612 Antigen processing and presentation 17/612 77/7206 0.000193424582257 ko05034 Alcoholism 6/612 238/7206 0.000208249528712 ko05152 Tuberculosis 31/612 187/7206 0.00026237391442 ko05144 Malaria 12/612 45/7206 0.000265699771256 ko00350 Tyrosine metabolism 10/612 33/7206 0.000277408355329 ko03010 Ribosome 1/612 129/7206 0.00030907584129 ko05323 Rheumatoid arthritis 18/612 89/7206 0.000402840294731 ko05330 Allograft rejection 8/612 24/7206 0.000557318775569 ko04710 Circadian rhythm 11/612 43/7206 0.000701174192488 ko04068 FoxO signaling pathway 27/612 167/7206 0.00102660954176 ko04146 Peroxisome 17/612 89/7206 0.00149508013677 ko04210 Apoptosis 28/612 180/7206 0.00158655422813 ko04622 RIG-I-like receptor signaling pathway 13/612 62/7206 0.00177781877153 ko04623 Cytosolic DNA-sensing pathway 10/612 41/7206 0.00180572328712 ko04390 Hippo signaling pathway 5/612 188/7206 0.00199201750364 ko00360 Phenylalanine metabolism 6/612 17/7206 0.00200615699467 ko05142 Chagas disease (American trypanosomiasis) 22/612 130/7206 0.0020464593767 ko05320 Autoimmune thyroid disease 8/612 29/7206 0.00222361802252 ko04640 Hematopoietic cell lineage 13/612 64/7206 0.00240172497885 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/612 135/7206 0.00263017513394 ko05332 Graft-versus-host disease 6/612 18/7206 0.00279602064928 ko05160 Hepatitis C 24/612 153/7206 0.00296334713524 ko04916 Melanogenesis 3/612 142/7206 0.00330471531945 ko00590 Arachidonic acid metabolism 11/612 52/7206 0.0036523268083 ko04723 Retrograde endocannabinoid signaling 5/612 175/7206 0.003669294404 ko00592 alpha-Linolenic acid metabolism 6/612 19/7206 0.00379747485012 ko04137 Mitophagy - animal 15/612 82/7206 0.00405688158942 ko03015 mRNA surveillance pathway 1/612 93/7206 0.00428919711521 ko04972 Pancreatic secretion 2/612 111/7206 0.00552906681546 ko00950 Isoquinoline alkaloid biosynthesis 4/612 10/7206 0.00714058230694 ko00051 Fructose and mannose metabolism 9/612 42/7206 0.00756698657741 ko04360 Axon guidance 9/612 233/7206 0.00806231272008 ko04666 Fc gamma R-mediated phagocytosis 19/612 122/7206 0.00821427420494 ko04540 Gap junction 3/612 128/7206 0.00928185459592 ko04310 Wnt signaling pathway 6/612 181/7206 0.00949088911799 ko04110 Cell cycle 4/612 145/7206 0.00954370503167 ko05132 Salmonella infection 16/612 98/7206 0.00956987460091 ko05310 Asthma 5/612 17/7206 0.0113609013322 ko04114 Oocyte meiosis 4/612 139/7206 0.0129532611907 ko04721 Synaptic vesicle cycle 1/612 80/7206 0.0136126097655 ko04740 Olfactory transduction 1/612 80/7206 0.0136126097655 ko04611 Platelet activation 23/612 163/7206 0.0147324672469 ko04728 Dopaminergic synapse 7/612 185/7206 0.0157659610405 ko00140 Steroid hormone biosynthesis 8/612 41/7206 0.0200744045502 ko04530 Tight junction 10/612 228/7206 0.0212585827822 ko04930 Type II diabetes mellitus 10/612 54/7206 0.0223293821739 ko04012 ErbB signaling pathway 3/612 109/7206 0.023931609485 ko05032 Morphine addiction 3/612 110/7206 0.0239829047069 ko05224 Breast cancer 7/612 174/7206 0.0275036288115 ko05217 Basal cell carcinoma 1/612 68/7206 0.0282637554368 ko04062 Chemokine signaling pathway 26/612 201/7206 0.0283662051673 ko05134 Legionellosis 12/612 74/7206 0.031860647897 ko00982 Drug metabolism - cytochrome P450 7/612 37/7206 0.033651513108 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/612 4/7206 0.0384890338768 ko00643 Styrene degradation 2/612 4/7206 0.0384890338768 ko04724 Glutamatergic synapse 6/612 152/7206 0.0390943397573 ko04713 Circadian entrainment 5/612 136/7206 0.0421253775349 ko04917 Prolactin signaling pathway 13/612 87/7206 0.0489364209476 ko04940 Type I diabetes mellitus 6/612 32/7206 0.0495462355759