ko pathway ratio_in_study ratio_in_pop p_value ko03010 Ribosome 1/951 129/7206 4.78019117011e-07 ko04713 Circadian entrainment 40/951 136/7206 5.07940937037e-07 ko04022 cGMP-PKG signaling pathway 55/951 216/7206 1.00413181418e-06 ko04020 Calcium signaling pathway 63/951 265/7206 1.76017254618e-06 ko00190 Oxidative phosphorylation 37/951 127/7206 1.76948570229e-06 ko03040 Spliceosome 3/951 145/7206 4.7182224132e-06 ko04966 Collecting duct acid secretion 13/951 26/7206 6.70640772005e-06 ko04070 Phosphatidylinositol signaling system 32/951 112/7206 1.39788296598e-05 ko04710 Circadian rhythm 17/951 43/7206 1.40373455835e-05 ko04922 Glucagon signaling pathway 35/951 128/7206 1.6048670205e-05 ko04146 Peroxisome 27/951 89/7206 2.03988549577e-05 ko04724 Glutamatergic synapse 39/951 152/7206 2.78786739068e-05 ko04921 Oxytocin signaling pathway 49/951 209/7206 4.16930346924e-05 ko04745 Phototransduction - fly 15/951 38/7206 4.59537179797e-05 ko05203 Viral carcinogenesis 16/951 277/7206 6.07095610026e-05 ko04720 Long-term potentiation 28/951 99/7206 6.25577369325e-05 ko04080 Neuroactive ligand-receptor interaction 84/951 423/7206 7.92387379598e-05 ko04970 Salivary secretion 27/951 95/7206 8.30123039319e-05 ko04110 Cell cycle 5/951 145/7206 9.7505366712e-05 ko04137 Mitophagy - animal 24/951 82/7206 0.000103418461202 ko05031 Amphetamine addiction 26/951 91/7206 0.000112193631841 ko04730 Long-term depression 23/951 78/7206 0.000131570372014 ko03013 RNA transport 7/951 166/7206 0.000168142812929 ko05322 Systemic lupus erythematosus 6/951 151/7206 0.000219107970214 ko04024 cAMP signaling pathway 58/951 279/7206 0.000290230707459 ko03008 Ribosome biogenesis in eukaryotes 1/951 79/7206 0.000316039220323 ko00120 Primary bile acid biosynthesis 9/951 20/7206 0.000501972873418 ko04728 Dopaminergic synapse 41/951 185/7206 0.000598299001502 ko04925 Aldosterone synthesis and secretion 27/951 105/7206 0.000647711695564 ko05110 Vibrio cholerae infection 18/951 63/7206 0.00107801943907 ko04626 Plant-pathogen interaction 8/951 18/7206 0.00114892117397 ko05323 Rheumatoid arthritis 23/951 89/7206 0.00128048816884 ko04721 Synaptic vesicle cycle 21/951 80/7206 0.00140057810625 ko04726 Serotonergic synapse 31/951 137/7206 0.00203782336384 ko05033 Nicotine addiction 16/951 56/7206 0.00214121853367 ko00051 Fructose and mannose metabolism 13/951 42/7206 0.00215493702839 ko04514 Cell adhesion molecules (CAMs) 30/951 130/7206 0.00230498033282 ko04270 Vascular smooth muscle contraction 34/951 154/7206 0.00234722303963 ko04727 GABAergic synapse 26/951 110/7206 0.00252604465896 ko05032 Morphine addiction 26/951 110/7206 0.00252604465896 ko04350 TGF-beta signaling pathway 4/951 103/7206 0.00291184564981 ko00680 Methane metabolism 11/951 34/7206 0.0031632662766 ko01200 Carbon metabolism 29/951 128/7206 0.00332434115943 ko04911 Insulin secretion 27/951 117/7206 0.00337047566392 ko00362 Benzoate degradation 4/951 6/7206 0.00362541389447 ko05010 Alzheimer's disease 41/951 202/7206 0.004185737931 ko04214 Apoptosis - fly 2/951 72/7206 0.00453565309567 ko04371 Apelin signaling pathway 37/951 177/7206 0.00458166090764 ko04550 Signaling pathways regulating pluripotency of stem cells 10/951 165/7206 0.00485255760305 ko04136 Autophagy - other 10/951 31/7206 0.00494015709457 ko04924 Renin secretion 21/951 86/7206 0.0055475480107 ko01212 Fatty acid metabolism 16/951 60/7206 0.00588195500098 ko00071 Fatty acid degradation 13/951 45/7206 0.00590482270351 ko04723 Retrograde endocannabinoid signaling 36/951 175/7206 0.00624323029958 ko00330 Arginine and proline metabolism 16/951 61/7206 0.00638867048805 ko03015 mRNA surveillance pathway 4/951 93/7206 0.00794367079708 ko00010 Glycolysis / Gluconeogenesis 18/951 74/7206 0.0085397674883 ko04725 Cholinergic synapse 33/951 160/7206 0.00879044024432 ko01230 Biosynthesis of amino acids 20/951 85/7206 0.00886451769993 ko04111 Cell cycle - yeast 4/951 90/7206 0.0111118146001 ko04261 Adrenergic signaling in cardiomyocytes 40/951 205/7206 0.011484077046 ko05224 Breast cancer 12/951 174/7206 0.0120469946593 ko01040 Biosynthesis of unsaturated fatty acids 8/951 25/7206 0.0121913374191 ko04068 FoxO signaling pathway 33/951 167/7206 0.0148338003505 ko04657 IL-17 signaling pathway 4/951 87/7206 0.0154944756952 ko00650 Butanoate metabolism 8/951 26/7206 0.0156230910696 ko04390 Hippo signaling pathway 14/951 188/7206 0.0159849256409 ko05169 Epstein-Barr virus infection 16/951 206/7206 0.0162730882373 ko04960 Aldosterone-regulated sodium reabsorption 11/951 41/7206 0.0176590494859 ko04145 Phagosome 32/951 162/7206 0.018161590938 ko05200 Pathways in cancer 48/951 492/7206 0.0188268291022 ko04138 Autophagy - yeast 18/951 81/7206 0.020696411427 ko04650 Natural killer cell mediated cytotoxicity 21/951 97/7206 0.021948950456 ko04971 Gastric acid secretion 21/951 98/7206 0.0228722527299 ko03420 Nucleotide excision repair 1/951 46/7206 0.025599222569 ko00562 Inositol phosphate metabolism 19/951 89/7206 0.0273357980993 ko05217 Basal cell carcinoma 3/951 68/7206 0.0292934773579 ko02010 ABC transporters 10/951 39/7206 0.0305700472456 ko00592 alpha-Linolenic acid metabolism 6/951 19/7206 0.0307941478417 ko05206 MicroRNAs in cancer 14/951 177/7206 0.0326332647409 ko04611 Platelet activation 31/951 163/7206 0.0342329429206 ko05100 Bacterial invasion of epithelial cells 6/951 99/7206 0.0350841777413 ko00640 Propanoate metabolism 9/951 34/7206 0.0365030449041 ko05130 Pathogenic Escherichia coli infection 4/951 77/7206 0.0401476592731 ko04750 Inflammatory mediator regulation of TRP channels 24/951 122/7206 0.0418785869843 ko00520 Amino sugar and nucleotide sugar metabolism 2/951 55/7206 0.0419837230316 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/951 92/7206 0.0425303497575 ko04740 Olfactory transduction 17/951 80/7206 0.0441277346359 ko00620 Pyruvate metabolism 11/951 46/7206 0.045327941008 ko04141 Protein processing in endoplasmic reticulum 15/951 184/7206 0.0460534078312 ko05152 Tuberculosis 34/951 187/7206 0.0481982439269